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- W4385336502 endingPage "165659" @default.
- W4385336502 startingPage "165659" @default.
- W4385336502 abstract "Plastic pollution has become a significant global problem over the years, leading to the continuous decomposition and accumulation of micro/nanoplastics (MNPLs) in the environment. As a result, human exposure to these MNPLs is inevitable. The liver, in particular, is highly susceptible to potential MNPL toxicity. In this study, we systematically reviewed the current literature on MNPLs-induced hepatotoxicity and collected data on toxic events occurring at different biological levels. Then, to better understand the cause-mechanism causality, we developed an Adverse Outcome Pathway (AOP) framework for MNPLs-induced hepatotoxicity. The AOP framework provided insights into the mechanism of MNPL-induced hepatotoxicity and highlighted potential health risks such as liver dysfunction and inflammation, metabolism disorders and liver fibrosis. Moreover, we discussed the potential application of emerging toxicological models in the hepatotoxicity study. Liver organoids and liver-on-chips, which can simulate the structure and function of the liver in vitro, offer a promising alternative platform for toxicity testing and risk assessment. We proposed combining the AOP framework with these emerging toxicological models to improve our understanding of the hepatotoxic effects of MNPLs. Overall, this study performed a preliminary exploration of novel toxicological methodologies to assess the hepatotoxicity of MNPLs, providing a deeper understanding of environmental toxicology." @default.
- W4385336502 created "2023-07-29" @default.
- W4385336502 creator A5002846482 @default.
- W4385336502 creator A5007295406 @default.
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- W4385336502 creator A5037341631 @default.
- W4385336502 creator A5038808022 @default.
- W4385336502 creator A5073806117 @default.
- W4385336502 date "2023-12-01" @default.
- W4385336502 modified "2023-10-17" @default.
- W4385336502 title "The hepatotoxicity assessment of micro/nanoplastics: A preliminary study to apply the adverse outcome pathways" @default.
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