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- W4385336817 abstract "Research Question: Does in vitro exposure of preimplantation mouse embryos to the ketone bodies β-hydroxybutyrate (βOHB) and acetoacetate (AcAc) impact post-transfer fetal and placental gene expression?DesignBlastocysts cultured in vitro with or without 2 mmol/L βOHB alone (‘βOHB’) or combined with 0.8 mmol/L AcAc (‘Keto’) underwent embryo transfer. Transcriptional profiles of sexed E14.5 placentae, liver, and brain were examined via RNA-Sequencing and DAVID functional analysis.Results: A sexually dimorphic response to in vitro ketone exposure was observed. βOHB and Keto exposure both downregulated genes related to oxidative phosphorylation specifically in female liver. βOHB downregulated female placental steroid biosynthetic processes, while Keto treatment upregulated genes relevant to blood vessel formation and cell migration in male placentae. Brain transcriptomes were minimally affected. X-linked genes and chromatin modifiers were identified as differentially expressed, alluding to a sex-specific regulatory mechanism.Conclusions: Transient preimplantation ketone exposure perturbs sex-specific fetal liver and placental gene expression demonstrating a developmental programming effect that warrants future investigation of male and female offspring postnatal metabolic health." @default.
- W4385336817 created "2023-07-29" @default.
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- W4385336817 date "2023-11-01" @default.
- W4385336817 modified "2023-09-27" @default.
- W4385336817 title "Preimplantation embryo exposure to ketone bodies exerts sex-specific effects on mouse fetal and placental transcriptomes" @default.
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- W4385336817 doi "https://doi.org/10.1016/j.rbmo.2023.103320" @default.
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