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• W4385337331 abstract "Carbapenems are effective against severe Pseudomonas aeruginosa nosocomial infections. Therefore, carbapenem-resistant Pseudomonas aeruginosa (CRPA) is a serious public health threat. An understanding of the risk of inappropriate exposure to different antimicrobials in resistant Pseudomonas aeruginosa infection could help in elucidating the effective approach towards using antimicrobials in vulnerable patients with CRPA infection. To investigate the association between exposure of β-lactam antimicrobials and CRPA infection relative to control patients. The MEDLINE/PubMed and OVID/Embase databases were used to search case-control and cohort studies in English language which reported antimicrobial exposure as risk factors for CRPA infection. The pooled odds ratios (OR) were calculated using a random-effect and fixed-effect model, and forest plots from a cumulative meta-analysis method were used to better show how pooled OR changed as updated evidence accumulated. A total of 24 studies comprising 7 039 participants were included for cumulative meta-analysis. A positive correlation was found between development of CRPA infection and exposure of beta-lactam antimicrobials: carbapenems [OR = 7.60, 95% CI: 3.95 to 14.62, P < 0.0001], imipenem [OR = 9.81, 95% CI: 5.56 to 17.33], ampicillin [OR = 1.86, 95% CI: 1.14 to 2.41], piperacillin [OR = 2.82, 95% CI: 1.46 to 2.43], penicillins [OR = 1.42, 95% CI: 0.90 to 2.24], cephalosporins [OR = 1.88, 95% CI: 1.46 to 2.43] and β lactamase inhibitors [OR = 1.96, 95% CI: 1.44 to 2.67]. Further, exposure of other antimicrobial agents like quinolone [OR = 2.35, 95% CI: 1.78 to 3.10], ciprofloxacin [OR = 2.35, 95% CI: 1.66 to 3.95], aminoglycoside [OR = 2.17, 95% CI: 1.60 to 2.95], amikacin [OR = 3.11, 95% CI: 2.10 to 4.61], glycopeptides [OR = 3.02, 95% CI: 1.92 to 4.75] and vancomycin [OR = 3.26, 95% CI: 1.48 to 7.18], were also found to be positively associated with development of CRPA infection. Exposure of all kinds of β-lactams is significantly associated with development of CRPA infection. These findings provide an impetus to take a more active approach while using β-lactam antimicrobials in patients with resistant Pseudomonas aeruginosa infections." @default.
• W4385337331 created "2023-07-29" @default.
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• W4385337331 date "2023-09-01" @default.
• W4385337331 modified "2023-09-26" @default.
• W4385337331 title "Association of β-lactam antimicrobial's exposure with carbapenem-resistant Pseudomonas aeruginosa infection: a cumulative meta-analysis" @default.
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• W4385337331 doi "https://doi.org/10.1016/j.glohj.2023.07.005" @default.
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