FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W43853402> ?p ?o ?g. }

• W43853402 endingPage "1995" @default.
• W43853402 startingPage "1987" @default.
• W43853402 abstract "Research Article1 May 1993free access Two novel protein kinase C-related genes of fission yeast are essential for cell viability and implicated in cell shape control. T. Toda T. Toda Department of Biophysics, Faculty of Science, Kyoto University, Japan. Search for more papers by this author M. Shimanuki M. Shimanuki Department of Biophysics, Faculty of Science, Kyoto University, Japan. Search for more papers by this author M. Yanagida M. Yanagida Department of Biophysics, Faculty of Science, Kyoto University, Japan. Search for more papers by this author T. Toda T. Toda Department of Biophysics, Faculty of Science, Kyoto University, Japan. Search for more papers by this author M. Shimanuki M. Shimanuki Department of Biophysics, Faculty of Science, Kyoto University, Japan. Search for more papers by this author M. Yanagida M. Yanagida Department of Biophysics, Faculty of Science, Kyoto University, Japan. Search for more papers by this author Author Information T. Toda1, M. Shimanuki1 and M. Yanagida1 1Department of Biophysics, Faculty of Science, Kyoto University, Japan. The EMBO Journal (1993)12:1987-1995https://doi.org/10.1002/j.1460-2075.1993.tb05848.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Two novel protein kinase C (PKC)-like genes, pck1+ and pck2+ were isolated from fission yeast by PCR. Both contain common domains of PKC-related molecules, but lack a putative Ca(2+)-binding domain so that they may belong to the nPKC group. Gene disruption of pck1+ and pck2+ establishes that they share an overlapping essential function for cell viability. Cells of a single pck2 deletion display severe defects in cell shape; they are irregular and sometimes pear-like instead of cylindrical. In contrast, the induced overexpression of pck2+ is lethal, producing multiseptated and branched cells. These results suggest that fission yeast PKC-like genes are involved in the polarity of cell growth control. We show that pck2 is allelic to sts6, a locus we have previously identified by its supersensitivity to staurosporine, a potent protein kinase inhibitor [Toda et al. (1991) Genes Dev., 5, 60–73]. In addition, the lethal overexpression of pck2+ can be suppressed by staurosporine, indicating that fission yeast pck1 and pck2 are molecular targets of this inhibitor. Previous ArticleNext Article Volume 12Issue 51 May 1993In this issue RelatedDetailsLoading ..." @default.
• W43853402 created "2016-06-24" @default.
• W43853402 creator A5004377531 @default.
• W43853402 creator A5036073850 @default.
• W43853402 creator A5076408807 @default.
• W43853402 date "1993-05-01" @default.
• W43853402 modified "2023-09-26" @default.
• W43853402 title "Two novel protein kinase C-related genes of fission yeast are essential for cell viability and implicated in cell shape control." @default.
• W43853402 cites W1490400638 @default.
• W43853402 cites W1528279723 @default.
• W43853402 cites W1537782690 @default.
• W43853402 cites W1551547664 @default.
• W43853402 cites W1589866689 @default.
• W43853402 cites W1616213090 @default.
• W43853402 cites W1650137855 @default.
• W43853402 cites W1748708005 @default.
• W43853402 cites W1889502940 @default.
• W43853402 cites W1970627065 @default.
• W43853402 cites W1971152163 @default.
• W43853402 cites W1973782344 @default.
• W43853402 cites W1975749117 @default.
• W43853402 cites W1977175322 @default.
• W43853402 cites W1979603393 @default.
• W43853402 cites W1980585800 @default.
• W43853402 cites W1984764741 @default.
• W43853402 cites W1991781635 @default.
• W43853402 cites W1993282564 @default.
• W43853402 cites W1995499596 @default.
• W43853402 cites W1998372019 @default.
• W43853402 cites W2001668713 @default.
• W43853402 cites W2001692359 @default.
• W43853402 cites W2007755820 @default.
• W43853402 cites W2013404388 @default.
• W43853402 cites W2014285665 @default.
• W43853402 cites W2017089619 @default.
• W43853402 cites W2018698400 @default.
• W43853402 cites W2019068828 @default.
• W43853402 cites W2020257412 @default.
• W43853402 cites W2021765529 @default.
• W43853402 cites W2024558939 @default.
• W43853402 cites W2029234227 @default.
• W43853402 cites W2029611498 @default.
• W43853402 cites W2032118018 @default.
• W43853402 cites W2033895281 @default.
• W43853402 cites W2035416711 @default.
• W43853402 cites W2043517704 @default.
• W43853402 cites W2046961979 @default.
• W43853402 cites W2047344741 @default.
• W43853402 cites W2048116173 @default.
• W43853402 cites W2050904776 @default.
• W43853402 cites W2054800842 @default.
• W43853402 cites W2061636074 @default.
• W43853402 cites W2062712010 @default.
• W43853402 cites W2064787601 @default.
• W43853402 cites W2076570789 @default.
• W43853402 cites W2080229333 @default.
• W43853402 cites W2083628540 @default.
• W43853402 cites W2086524338 @default.
• W43853402 cites W2088206337 @default.
• W43853402 cites W2089969587 @default.
• W43853402 cites W2090306001 @default.
• W43853402 cites W2091673674 @default.
• W43853402 cites W2095485865 @default.
• W43853402 cites W2135051126 @default.
• W43853402 cites W2136674751 @default.
• W43853402 cites W2138270253 @default.
• W43853402 cites W2147599690 @default.
• W43853402 cites W2174520807 @default.
• W43853402 cites W2178456244 @default.
• W43853402 cites W2188979715 @default.
• W43853402 cites W2194986544 @default.
• W43853402 cites W59251478 @default.
• W43853402 doi "https://doi.org/10.1002/j.1460-2075.1993.tb05848.x" @default.
• W43853402 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/413420" @default.
• W43853402 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8491190" @default.
• W43853402 hasPublicationYear "1993" @default.
• W43853402 type Work @default.
• W43853402 sameAs 43853402 @default.
• W43853402 citedByCount "125" @default.
• W43853402 countsByYear W438534022013 @default.
• W43853402 countsByYear W438534022015 @default.
• W43853402 countsByYear W438534022017 @default.
• W43853402 countsByYear W438534022018 @default.
• W43853402 countsByYear W438534022020 @default.
• W43853402 countsByYear W438534022021 @default.
• W43853402 countsByYear W438534022022 @default.
• W43853402 countsByYear W438534022023 @default.
• W43853402 crossrefType "journal-article" @default.
• W43853402 hasAuthorship W43853402A5004377531 @default.
• W43853402 hasAuthorship W43853402A5036073850 @default.
• W43853402 hasAuthorship W43853402A5076408807 @default.
• W43853402 hasBestOaLocation W438534021 @default.
• W43853402 hasConcept C104317684 @default.
• W43853402 hasConcept C121332964 @default.
• W43853402 hasConcept C12294094 @default.
• W43853402 hasConcept C152568617 @default.
• W43853402 hasConcept C161191863 @default.
• W43853402 hasConcept C185544564 @default.

• next