Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385341200> ?p ?o ?g. }
- W4385341200 endingPage "7277" @default.
- W4385341200 startingPage "7258" @default.
- W4385341200 abstract "Chronic inflammation and lipid peroxidation (LPO) are associated with the pathogenesis of hepatocellular carcinoma (HCC), and γ-hydroxy-1, N2-propanodeoxyguanosine (γ-OHPdG) is a promutagenic DNA adduct derived from LPO. This study aimed to examine the relationship between γ-OHPdG and the progression of liver carcinogenesis.Primary HCC specimens were obtained from 228 patients and cirrhosis specimens from 46 patients. The patients were followed up with after surgery via outpatient visits and telephone calls. The levels of γ-OHPdG were determined by immunohistochemical analysis in the carcinomatous tissues together with adjacent and cirrhosis tissues.γ-OHPdG levels in the cancerous tissues were significantly higher compared to adjacent tissues (P < 0.001) and also higher than the ones from the tissues of cirrhosis patients. Along with tumor size, histological grade, MVI grade, T stage, the percentage of ki67-positive cells and HCC progression, γ-OHPdG levels in cancerous tissues showed a gradually increasing trend. Moreover, prognostic analysis showed that higher γ-OHPdG levels in cancerous tissues were strongly correlated with lower overall survival (P < 0.001), lower intrahepatic recurrence-free survival (P < 0.001) and lower distant metastasis-free survival (P < 0.05). There was a trend, although not statistically significant, of increased levels of γ-OHPdG in cirrhosis cases that advanced to HCC, whereas γ-OHPdG levels reversely correlated with the period of time observed for cirrhosis advanced to HCC.These results suggest that γ-OHPdG is a prognostic biomarker for predicting outcomes in HCC, and may serve as a prospective indicator for predicting HCC in cirrhosis patients." @default.
- W4385341200 created "2023-07-29" @default.
- W4385341200 creator A5001856137 @default.
- W4385341200 creator A5011689931 @default.
- W4385341200 creator A5019930385 @default.
- W4385341200 creator A5030404626 @default.
- W4385341200 creator A5038984243 @default.
- W4385341200 creator A5050777733 @default.
- W4385341200 creator A5051569678 @default.
- W4385341200 creator A5054349869 @default.
- W4385341200 creator A5054835425 @default.
- W4385341200 creator A5071348051 @default.
- W4385341200 creator A5079417201 @default.
- W4385341200 date "2023-07-28" @default.
- W4385341200 modified "2023-10-14" @default.
- W4385341200 title "The lipid peroxidation-derived DNA adduct γ-OHPdG as a diagnostic and prognostic biomarker in hepatocellular carcinoma" @default.
- W4385341200 cites W1530007295 @default.
- W4385341200 cites W1965795556 @default.
- W4385341200 cites W1977760988 @default.
- W4385341200 cites W2003920262 @default.
- W4385341200 cites W2005551174 @default.
- W4385341200 cites W2007208208 @default.
- W4385341200 cites W2008255315 @default.
- W4385341200 cites W2014055683 @default.
- W4385341200 cites W2014695168 @default.
- W4385341200 cites W2023503151 @default.
- W4385341200 cites W2045556691 @default.
- W4385341200 cites W2055175046 @default.
- W4385341200 cites W2056373849 @default.
- W4385341200 cites W2068127752 @default.
- W4385341200 cites W2070245532 @default.
- W4385341200 cites W2076748580 @default.
- W4385341200 cites W2084141237 @default.
- W4385341200 cites W2106577742 @default.
- W4385341200 cites W2111992881 @default.
- W4385341200 cites W2125161809 @default.
- W4385341200 cites W2141547031 @default.
- W4385341200 cites W2168535299 @default.
- W4385341200 cites W2202349529 @default.
- W4385341200 cites W2529051581 @default.
- W4385341200 cites W2552389495 @default.
- W4385341200 cites W2736458955 @default.
- W4385341200 cites W2738118286 @default.
- W4385341200 cites W2747395172 @default.
- W4385341200 cites W2795488377 @default.
- W4385341200 cites W2808293799 @default.
- W4385341200 cites W2809889937 @default.
- W4385341200 cites W2887668369 @default.
- W4385341200 cites W2924534120 @default.
- W4385341200 cites W2953282350 @default.
- W4385341200 cites W2980064491 @default.
- W4385341200 cites W2995012900 @default.
- W4385341200 cites W2999417355 @default.
- W4385341200 cites W3011410259 @default.
- W4385341200 cites W3011816813 @default.
- W4385341200 cites W3030956000 @default.
- W4385341200 cites W3128646645 @default.
- W4385341200 cites W3161294930 @default.
- W4385341200 cites W4200185066 @default.
- W4385341200 cites W4211183069 @default.
- W4385341200 cites W4231746566 @default.
- W4385341200 doi "https://doi.org/10.18632/aging.204910" @default.
- W4385341200 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37517089" @default.
- W4385341200 hasPublicationYear "2023" @default.
- W4385341200 type Work @default.
- W4385341200 citedByCount "0" @default.
- W4385341200 crossrefType "journal-article" @default.
- W4385341200 hasAuthorship W4385341200A5001856137 @default.
- W4385341200 hasAuthorship W4385341200A5011689931 @default.
- W4385341200 hasAuthorship W4385341200A5019930385 @default.
- W4385341200 hasAuthorship W4385341200A5030404626 @default.
- W4385341200 hasAuthorship W4385341200A5038984243 @default.
- W4385341200 hasAuthorship W4385341200A5050777733 @default.
- W4385341200 hasAuthorship W4385341200A5051569678 @default.
- W4385341200 hasAuthorship W4385341200A5054349869 @default.
- W4385341200 hasAuthorship W4385341200A5054835425 @default.
- W4385341200 hasAuthorship W4385341200A5071348051 @default.
- W4385341200 hasAuthorship W4385341200A5079417201 @default.
- W4385341200 hasBestOaLocation W43853412001 @default.
- W4385341200 hasConcept C121608353 @default.
- W4385341200 hasConcept C126322002 @default.
- W4385341200 hasConcept C142724271 @default.
- W4385341200 hasConcept C143998085 @default.
- W4385341200 hasConcept C204232928 @default.
- W4385341200 hasConcept C2776151105 @default.
- W4385341200 hasConcept C2777214474 @default.
- W4385341200 hasConcept C2778019345 @default.
- W4385341200 hasConcept C2779013556 @default.
- W4385341200 hasConcept C2780829032 @default.
- W4385341200 hasConcept C2780942790 @default.
- W4385341200 hasConcept C2781197716 @default.
- W4385341200 hasConcept C55493867 @default.
- W4385341200 hasConcept C555283112 @default.
- W4385341200 hasConcept C71924100 @default.
- W4385341200 hasConcept C86803240 @default.
- W4385341200 hasConcept C90924648 @default.
- W4385341200 hasConceptScore W4385341200C121608353 @default.
- W4385341200 hasConceptScore W4385341200C126322002 @default.