Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385346190> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W4385346190 endingPage "1637" @default.
- W4385346190 startingPage "1637" @default.
- W4385346190 abstract "Background: Historically, cervical cytology has been the standard method for detecting dysplastic cervical changes. However, extensive research has established that human papillomavirus (HPV) infection is a primary cause of these changes, necessitating a shift in screening and preventive strategies towards the molecular detection of high-risk HPV subtypes. To combat HPV infection, prophylactic vaccines have been developed, including the nonavalent, quadrivalent, and bivalent vaccines. An essential criterion for an effective HPV vaccine is to provide comprehensive coverage against the most prevalent high-risk HPV types associated with cervical cancer, ensuring optimal efficacy in preventing cervical lesions. Long-term protection against these types is crucial for effective prevention strategies; Material and Methods: A cohort of 210,510 women’s samples was included in the analysis conducted within one year of implementing a screening program in Germany. The screening program involved the molecular detection of high-risk HPV subtypes, targeting specific age groups. The cohort comprised 63,710 women below 35 years of age and 146,800 women aged 35 years and above. The selection of high-risk HPV subtypes followed the guidelines provided by Becton-Dickinson. This study focused exclusively on cases with a documented history of vaccination, which were categorized into two main groups: Group I consisted of vaccinated individuals under 35 years old (12,765 cases), while Group II comprised vaccinated individuals aged 35 years and above (296 cases); Results: The HPV types HPV56/59/66 were found to be widely distributed across all age groups, with certain age groups exhibiting a higher incidence compared to HPV16 and HPV18. Similarly, HPV35/39/69, along with HPV31 and HPV45, were also observed to have a broad distribution among women. The incidence of high-grade squamous intraepithelial lesions (HSIL), including both CIN2 and CIN3, varied between 0.076% and 0.5% across all age groups, regardless of the individuals’ vaccination status; Aim of the study: Our study provides valuable insights into the distribution, incidence, and prevalence of various high-risk HPV subtypes, including HPV56/59/66, HPV33/58, HPV35/39/68, and HPV45, in relation to precancerous cervical lesions. These subtypes are not adequately covered by the currently available HPV vaccines. Addressing the discrepancies between the prevalent HPV subtypes and existing vaccines is crucial in developing an ideal HPV vaccine that offers comprehensive protection. Tailoring screening programs and vaccination strategies to the local distribution of HPV subtypes is essential for effective prevention. By raising awareness and implementing targeted preventive measures, including vaccination, we can significantly reduce the incidence of precancerous and cancerous cervical lesions." @default.
- W4385346190 created "2023-07-29" @default.
- W4385346190 creator A5015436832 @default.
- W4385346190 creator A5043196873 @default.
- W4385346190 creator A5075961869 @default.
- W4385346190 date "2023-07-27" @default.
- W4385346190 modified "2023-09-26" @default.
- W4385346190 title "Prevalence of High-Risk HPV Subtypes and Efficacy of the HPV Vaccine in Preventing Cervical Epithelial Lesions: Survey and Insights from a German Study" @default.
- W4385346190 cites W1814405991 @default.
- W4385346190 cites W1939811650 @default.
- W4385346190 cites W2010596037 @default.
- W4385346190 cites W2045600910 @default.
- W4385346190 cites W2076539170 @default.
- W4385346190 cites W2120078697 @default.
- W4385346190 cites W2137605711 @default.
- W4385346190 cites W2139736159 @default.
- W4385346190 cites W2161192994 @default.
- W4385346190 cites W2170787470 @default.
- W4385346190 cites W2189263758 @default.
- W4385346190 cites W2221837786 @default.
- W4385346190 cites W2314847570 @default.
- W4385346190 cites W2552050620 @default.
- W4385346190 cites W2565083543 @default.
- W4385346190 cites W3040826070 @default.
- W4385346190 cites W3048786232 @default.
- W4385346190 cites W3087526598 @default.
- W4385346190 cites W3089984332 @default.
- W4385346190 cites W4206351854 @default.
- W4385346190 cites W4298414283 @default.
- W4385346190 cites W4382699418 @default.
- W4385346190 doi "https://doi.org/10.3390/life13081637" @default.
- W4385346190 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37629494" @default.
- W4385346190 hasPublicationYear "2023" @default.
- W4385346190 type Work @default.
- W4385346190 citedByCount "0" @default.
- W4385346190 crossrefType "journal-article" @default.
- W4385346190 hasAuthorship W4385346190A5015436832 @default.
- W4385346190 hasAuthorship W4385346190A5043196873 @default.
- W4385346190 hasAuthorship W4385346190A5075961869 @default.
- W4385346190 hasBestOaLocation W43853461901 @default.
- W4385346190 hasConcept C120665830 @default.
- W4385346190 hasConcept C121332964 @default.
- W4385346190 hasConcept C121608353 @default.
- W4385346190 hasConcept C126322002 @default.
- W4385346190 hasConcept C143998085 @default.
- W4385346190 hasConcept C203014093 @default.
- W4385346190 hasConcept C22070199 @default.
- W4385346190 hasConcept C2778220009 @default.
- W4385346190 hasConcept C2778580637 @default.
- W4385346190 hasConcept C2780009117 @default.
- W4385346190 hasConcept C2780441014 @default.
- W4385346190 hasConcept C2780647465 @default.
- W4385346190 hasConcept C29456083 @default.
- W4385346190 hasConcept C2994532551 @default.
- W4385346190 hasConcept C61511704 @default.
- W4385346190 hasConcept C71924100 @default.
- W4385346190 hasConcept C72563966 @default.
- W4385346190 hasConceptScore W4385346190C120665830 @default.
- W4385346190 hasConceptScore W4385346190C121332964 @default.
- W4385346190 hasConceptScore W4385346190C121608353 @default.
- W4385346190 hasConceptScore W4385346190C126322002 @default.
- W4385346190 hasConceptScore W4385346190C143998085 @default.
- W4385346190 hasConceptScore W4385346190C203014093 @default.
- W4385346190 hasConceptScore W4385346190C22070199 @default.
- W4385346190 hasConceptScore W4385346190C2778220009 @default.
- W4385346190 hasConceptScore W4385346190C2778580637 @default.
- W4385346190 hasConceptScore W4385346190C2780009117 @default.
- W4385346190 hasConceptScore W4385346190C2780441014 @default.
- W4385346190 hasConceptScore W4385346190C2780647465 @default.
- W4385346190 hasConceptScore W4385346190C29456083 @default.
- W4385346190 hasConceptScore W4385346190C2994532551 @default.
- W4385346190 hasConceptScore W4385346190C61511704 @default.
- W4385346190 hasConceptScore W4385346190C71924100 @default.
- W4385346190 hasConceptScore W4385346190C72563966 @default.
- W4385346190 hasIssue "8" @default.
- W4385346190 hasLocation W43853461901 @default.
- W4385346190 hasLocation W43853461902 @default.
- W4385346190 hasLocation W43853461903 @default.
- W4385346190 hasOpenAccess W4385346190 @default.
- W4385346190 hasPrimaryLocation W43853461901 @default.
- W4385346190 hasRelatedWork W1975501975 @default.
- W4385346190 hasRelatedWork W1976418033 @default.
- W4385346190 hasRelatedWork W2041694303 @default.
- W4385346190 hasRelatedWork W2044839959 @default.
- W4385346190 hasRelatedWork W2166655976 @default.
- W4385346190 hasRelatedWork W2775338190 @default.
- W4385346190 hasRelatedWork W2907319927 @default.
- W4385346190 hasRelatedWork W2935789071 @default.
- W4385346190 hasRelatedWork W315926151 @default.
- W4385346190 hasRelatedWork W4247913852 @default.
- W4385346190 hasVolume "13" @default.
- W4385346190 isParatext "false" @default.
- W4385346190 isRetracted "false" @default.
- W4385346190 workType "article" @default.