FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385347844> ?p ?o ?g. }

• W4385347844 endingPage "12027" @default.
• W4385347844 startingPage "12027" @default.
• W4385347844 abstract "Sepsis is a life-threatening condition that results from an overwhelming and disproportionate host response to an infection. Currently, the quality and extent of the immune response are evaluated based on clinical symptoms and the concentration of inflammatory biomarkers released or expressed by the immune cells. However, the host response toward sepsis is heterogeneous, and the roles of the individual immune cell types have not been fully conceptualized. During sepsis, the spleen plays a vital role in pathogen clearance, such as bacteria by an antibody response, macrophage bactericidal capacity, and bacterial endotoxin detoxification. This study uses Raman spectroscopy to understand the splenic T-lymphocyte compartment profile changes during bona fide bacterial sepsis versus hyperinflammatory endotoxemia. The Raman spectral analysis showed marked changes in splenocytes of mice subjected to septic peritonitis principally in the DNA region, with minor changes in the amino acids and lipoprotein areas, indicating significant transcriptomic activity during sepsis. Furthermore, splenocytes from mice exposed to endotoxic shock by injection of a high dose of lipopolysaccharide showed significant changes in the protein and lipid profiles, albeit with interindividual variations in inflammation severity. In summary, this study provided experimental evidence for the applicability and informative value of Raman spectroscopy for profiling the immune response in a complex, systemic infection scenario. Importantly, changes within the acute phase of inflammation onset (24 h) were reliably detected, lending support to the concept of early treatment and severity control by extracorporeal Raman profiling of immunocyte signatures." @default.
• W4385347844 created "2023-07-29" @default.
• W4385347844 creator A5005568675 @default.
• W4385347844 creator A5018774424 @default.
• W4385347844 creator A5027717692 @default.
• W4385347844 creator A5048291863 @default.
• W4385347844 creator A5058949925 @default.
• W4385347844 creator A5075821902 @default.
• W4385347844 creator A5091969387 @default.
• W4385347844 date "2023-07-27" @default.
• W4385347844 modified "2023-09-26" @default.
• W4385347844 title "Raman Spectroscopy Profiling of Splenic T-Cells in Sepsis and Endotoxemia in Mice" @default.
• W4385347844 cites W1421625302 @default.
• W4385347844 cites W1964465796 @default.
• W4385347844 cites W1980129693 @default.
• W4385347844 cites W1984153512 @default.
• W4385347844 cites W1999634645 @default.
• W4385347844 cites W2003824127 @default.
• W4385347844 cites W2030845518 @default.
• W4385347844 cites W2051485193 @default.
• W4385347844 cites W2052940553 @default.
• W4385347844 cites W2078163396 @default.
• W4385347844 cites W2096428863 @default.
• W4385347844 cites W2107877347 @default.
• W4385347844 cites W2108387130 @default.
• W4385347844 cites W2135295279 @default.
• W4385347844 cites W2167433809 @default.
• W4385347844 cites W2169523957 @default.
• W4385347844 cites W2308290533 @default.
• W4385347844 cites W2524387459 @default.
• W4385347844 cites W2531213272 @default.
• W4385347844 cites W2556416675 @default.
• W4385347844 cites W2620051781 @default.
• W4385347844 cites W2750243369 @default.
• W4385347844 cites W2761356900 @default.
• W4385347844 cites W2778797754 @default.
• W4385347844 cites W2783439615 @default.
• W4385347844 cites W2789026035 @default.
• W4385347844 cites W2793847996 @default.
• W4385347844 cites W2889576817 @default.
• W4385347844 cites W2912272312 @default.
• W4385347844 cites W2945147189 @default.
• W4385347844 cites W2999149075 @default.
• W4385347844 cites W3006033724 @default.
• W4385347844 cites W3044425341 @default.
• W4385347844 cites W3044577971 @default.
• W4385347844 cites W3083237781 @default.
• W4385347844 cites W3095941555 @default.
• W4385347844 cites W3111291625 @default.
• W4385347844 cites W3135438354 @default.
• W4385347844 cites W3146995974 @default.
• W4385347844 cites W3153644797 @default.
• W4385347844 cites W3162919938 @default.
• W4385347844 cites W3164931667 @default.
• W4385347844 cites W3197063596 @default.
• W4385347844 cites W3199389638 @default.
• W4385347844 cites W3204382314 @default.
• W4385347844 cites W3209606246 @default.
• W4385347844 cites W4200159437 @default.
• W4385347844 cites W4206225046 @default.
• W4385347844 cites W4224863679 @default.
• W4385347844 cites W4229656522 @default.
• W4385347844 cites W4287509860 @default.
• W4385347844 cites W4292209017 @default.
• W4385347844 cites W4307190334 @default.
• W4385347844 doi "https://doi.org/10.3390/ijms241512027" @default.
• W4385347844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37569403" @default.
• W4385347844 hasPublicationYear "2023" @default.
• W4385347844 type Work @default.
• W4385347844 citedByCount "0" @default.
• W4385347844 crossrefType "journal-article" @default.
• W4385347844 hasAuthorship W4385347844A5005568675 @default.
• W4385347844 hasAuthorship W4385347844A5018774424 @default.
• W4385347844 hasAuthorship W4385347844A5027717692 @default.
• W4385347844 hasAuthorship W4385347844A5048291863 @default.
• W4385347844 hasAuthorship W4385347844A5058949925 @default.
• W4385347844 hasAuthorship W4385347844A5075821902 @default.
• W4385347844 hasAuthorship W4385347844A5091969387 @default.
• W4385347844 hasBestOaLocation W43853478441 @default.
• W4385347844 hasConcept C189976730 @default.
• W4385347844 hasConcept C203014093 @default.
• W4385347844 hasConcept C2776252253 @default.
• W4385347844 hasConcept C2776914184 @default.
• W4385347844 hasConcept C2777628635 @default.
• W4385347844 hasConcept C2778384902 @default.
• W4385347844 hasConcept C2778754761 @default.
• W4385347844 hasConcept C2780931953 @default.
• W4385347844 hasConcept C71924100 @default.
• W4385347844 hasConcept C86803240 @default.
• W4385347844 hasConcept C8891405 @default.
• W4385347844 hasConcept C89423630 @default.
• W4385347844 hasConceptScore W4385347844C189976730 @default.
• W4385347844 hasConceptScore W4385347844C203014093 @default.
• W4385347844 hasConceptScore W4385347844C2776252253 @default.
• W4385347844 hasConceptScore W4385347844C2776914184 @default.
• W4385347844 hasConceptScore W4385347844C2777628635 @default.
• W4385347844 hasConceptScore W4385347844C2778384902 @default.
• W4385347844 hasConceptScore W4385347844C2778754761 @default.

• next