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- W4385350037 abstract "Abstract Background Norovirus is now recognized to be major cause of gastroenteritis worldwide, with significantly higher disease burden among immunocompromised patients. This study aimed to determine the prevalence of Norovirus among HIV patients and to evaluate the impact of Highly active antiretroviral therapy (HAART) status on Norovirus prevalence in a sub-urban area of Abuja, Nigeria. Methods This study included a total of Two hundred and fifteen subjects (85 HAART-naïve and 130 HAART-exposed) HIV patients. Age range of study participants was 18 to 60 years. Faecal specimens where collected in screw capped containers and analyzed for Norovirus using Accupower Norovirus real-time PCR Test kit. CD4 cell count was determined using flow cytometry. Results The prevalence of Norovirus among HAART-naïve HIV patients was 10.6%. Age and gender was not associated with norovirus infection. HAART –naïve HIV patients with CD4 cell count < 200 was significantly more infected with Norovirus as compared to those with CD4 count ≥ 200 (OR: 28.000, 95% CI 3.2237, 243.2007, P = 0.0025). Norovirus was also found to be significantly higher in HAART-naïve HIV patients than amongst HAART-exposed counterparts (OR: 6.882, 95% CI: 1.4514, 32.6343, P = 0.015). Conclusions The prevalence of Norovirus among HAART-naïve HIV patients was high; and was significantly higher in subjects with low CD4 counts. Screening for Norovirus among HAART-naïve HIV patients is however emphasized to allow for effective Norovirus disease management." @default.
- W4385350037 created "2023-07-29" @default.
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- W4385350037 date "2023-07-28" @default.
- W4385350037 modified "2023-09-24" @default.
- W4385350037 title "Norovirus infection among HIV patients in Abuja, Nigeria: impact of Highly Active Antiretroviral therapy status" @default.
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- W4385350037 doi "https://doi.org/10.21203/rs.3.rs-3142055/v1" @default.
- W4385350037 hasPublicationYear "2023" @default.
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