FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385355026> ?p ?o ?g. }

• W4385355026 endingPage "669" @default.
• W4385355026 startingPage "647" @default.
• W4385355026 abstract "Protein arginine methylation is a widespread post-translational modification (PTM) in eukaryotic cells. This chemical modification in proteins functionally modulates diverse cellular processes from signal transduction, gene expression, and DNA damage repair to RNA splicing. The chemistry of arginine methylation entails the transfer of the methyl group from S-adenosyl-l-methionine (AdoMet, SAM) onto a guanidino nitrogen atom of an arginine residue of a target protein. This reaction is catalyzed by about 10 members of protein arginine methyltransferases (PRMTs). With impacts on a variety of cellular processes, aberrant expression and activity of PRMTs have been shown in many disease conditions. Particularly in oncology, PRMTs are commonly overexpressed in many cancerous tissues and positively correlated with tumor initiation, development and progression. As such, targeting PRMTs is increasingly recognized as an appealing therapeutic strategy for new drug discovery. In the past decade, a great deal of research efforts has been invested in illuminating PRMT functions in diseases and developing chemical probes for the mechanistic study of PRMTs in biological systems. In this review, we provide a brief developmental history of arginine methylation along with some key updates in arginine methylation research, with a particular emphasis on the chemical aspects of arginine methylation. We highlight the research endeavors for the development and application of chemical approaches and chemical tools for the study of functions of PRMTs and arginine methylation in regulating biology and disease." @default.
• W4385355026 created "2023-07-29" @default.
• W4385355026 creator A5011877804 @default.
• W4385355026 creator A5013486583 @default.
• W4385355026 creator A5019755286 @default.
• W4385355026 creator A5068134461 @default.
• W4385355026 date "2023-01-01" @default.
• W4385355026 modified "2023-10-17" @default.
• W4385355026 title "Chemical probes and methods for the study of protein arginine methylation" @default.
• W4385355026 cites W1492953040 @default.
• W4385355026 cites W1517861362 @default.
• W4385355026 cites W1532382821 @default.
• W4385355026 cites W1532675490 @default.
• W4385355026 cites W1623721186 @default.
• W4385355026 cites W1630913723 @default.
• W4385355026 cites W1906785372 @default.
• W4385355026 cites W1907409252 @default.
• W4385355026 cites W1967887313 @default.
• W4385355026 cites W1968021983 @default.
• W4385355026 cites W1968652549 @default.
• W4385355026 cites W1970274256 @default.
• W4385355026 cites W1970569586 @default.
• W4385355026 cites W1973649172 @default.
• W4385355026 cites W1975156117 @default.
• W4385355026 cites W1976468233 @default.
• W4385355026 cites W1976901070 @default.
• W4385355026 cites W1984929731 @default.
• W4385355026 cites W1986510342 @default.
• W4385355026 cites W1986955438 @default.
• W4385355026 cites W1988803246 @default.
• W4385355026 cites W1991132962 @default.
• W4385355026 cites W1994971290 @default.
• W4385355026 cites W1995190020 @default.
• W4385355026 cites W1995286508 @default.
• W4385355026 cites W1996682649 @default.
• W4385355026 cites W199863602 @default.
• W4385355026 cites W1999112642 @default.
• W4385355026 cites W2000066290 @default.
• W4385355026 cites W2003514819 @default.
• W4385355026 cites W2003960419 @default.
• W4385355026 cites W2004226525 @default.
• W4385355026 cites W2004593599 @default.
• W4385355026 cites W2005454275 @default.
• W4385355026 cites W2006111867 @default.
• W4385355026 cites W2008876829 @default.
• W4385355026 cites W2010269082 @default.
• W4385355026 cites W2010510740 @default.
• W4385355026 cites W2010899127 @default.
• W4385355026 cites W2011104528 @default.
• W4385355026 cites W2012559147 @default.
• W4385355026 cites W2012706719 @default.
• W4385355026 cites W2013168688 @default.
• W4385355026 cites W2014747141 @default.
• W4385355026 cites W2015416439 @default.
• W4385355026 cites W2015475080 @default.
• W4385355026 cites W2018339027 @default.
• W4385355026 cites W2018541344 @default.
• W4385355026 cites W2018636955 @default.
• W4385355026 cites W2021067645 @default.
• W4385355026 cites W2021790986 @default.
• W4385355026 cites W2022433519 @default.
• W4385355026 cites W2024117157 @default.
• W4385355026 cites W2025277638 @default.
• W4385355026 cites W2028149832 @default.
• W4385355026 cites W2032442871 @default.
• W4385355026 cites W2035536565 @default.
• W4385355026 cites W2042488075 @default.
• W4385355026 cites W2042496825 @default.
• W4385355026 cites W2042883526 @default.
• W4385355026 cites W2043274355 @default.
• W4385355026 cites W2046468403 @default.
• W4385355026 cites W2046816028 @default.
• W4385355026 cites W2046822862 @default.
• W4385355026 cites W2048418221 @default.
• W4385355026 cites W2049118898 @default.
• W4385355026 cites W2050064738 @default.
• W4385355026 cites W2050414506 @default.
• W4385355026 cites W2050569914 @default.
• W4385355026 cites W2051844493 @default.
• W4385355026 cites W2052249304 @default.
• W4385355026 cites W2055200974 @default.
• W4385355026 cites W2055220494 @default.
• W4385355026 cites W2056286919 @default.
• W4385355026 cites W2057379290 @default.
• W4385355026 cites W2058289726 @default.
• W4385355026 cites W2060596553 @default.
• W4385355026 cites W2062768506 @default.
• W4385355026 cites W2062864226 @default.
• W4385355026 cites W2066050590 @default.
• W4385355026 cites W2067685926 @default.
• W4385355026 cites W2068899800 @default.
• W4385355026 cites W2071576183 @default.
• W4385355026 cites W2071751135 @default.
• W4385355026 cites W2074287116 @default.
• W4385355026 cites W2075628440 @default.
• W4385355026 cites W2076142854 @default.
• W4385355026 cites W2076277117 @default.
• W4385355026 cites W2077247175 @default.

• next