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- W4385355565 endingPage "11690" @default.
- W4385355565 startingPage "11679" @default.
- W4385355565 abstract "Ruthenium-based complexes have been suggested as promising anticancer drugs exhibiting reduced general toxicity compared to platinum-based drugs. In particular, Ru(η6-arene)(PTA)Cl2 (PTA = 1,3,5-triaza-7-phosphaadamantane), or RAPTA, complexes have demonstrated efficacy against breast cancer by suppressing metastasis, tumorigenicity, and inhibiting the replication of the human tumor suppressor gene BRCA1. However, RAPTA compounds have limited cytotoxicity, and therefore comparatively high doses are required. This study explores the activity of a series of RAPTA-like ruthenium(II) arene compounds against MCF-7 and MDA-MB-231 breast cancer cell lines and [Ru(η6-toluene)(PPh3)2Cl]+ was identified as a promising candidate. Notably, [Ru(η6-toluene)(PPh3)2Cl]Cl was found to be remarkably stable and highly cytotoxic, and selective to breast cancer cells. The minor groove of DNA was identified as a relevant target." @default.
- W4385355565 created "2023-07-29" @default.
- W4385355565 creator A5044433603 @default.
- W4385355565 creator A5051488968 @default.
- W4385355565 creator A5064462111 @default.
- W4385355565 creator A5082243615 @default.
- W4385355565 creator A5089293611 @default.
- W4385355565 creator A5092562872 @default.
- W4385355565 date "2023-01-01" @default.
- W4385355565 modified "2023-10-15" @default.
- W4385355565 title "Fine-tuning the cytotoxicity of ruthenium(<scp>ii</scp>) arene compounds to enhance selectivity against breast cancers" @default.
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