Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385358567> ?p ?o ?g. }
- W4385358567 endingPage "117194" @default.
- W4385358567 startingPage "117194" @default.
- W4385358567 abstract "Despite interest in the use of polygenic risk scores (PRS) for predicting coronary heart disease (CHD) risk, the clinical utility of PRS compared to conventional risk factors has not been demonstrated. We compared the performance of PRS with that of high-sensitivity C-reactive protein (hsCRP) in two well-established cohorts.The study population included individuals of European ancestry free of baseline CHD from ARIC (N = 13,113) and the Framingham Offspring Study (FHS) (N = 2,696). The primary predictors included a validated PRS consisting of >6.6 million single nucleotide polymorphisms and hsCRP. The outcome was incident CHD, defined as non-fatal or fatal myocardial infarction. We compared the performance of both predictors after adjusting for the Pooled Cohort Equations in multivariable-adjusted Cox regression models. We assessed discrimination and reclassification using c-statistics and net reclassification improvement.Incident CHD occurred in 565 ARIC and 153 FHS participants. In multivariable-adjusted models, both PRS and hsCRP were associated with incident CHD (p < 0.05 in both cohorts). In models incorporating both predictors, strengths of association were similar. For instance, in ARIC, the hazard ratio per SD increment was 1.38 (95% CI, 1.27-1.50, p = 2.94 × 10-14) for PRS and 1.41 (1.30-1.55, p = 3.10 × 10-15) for hsCRP. Neither predictor significantly increased model discrimination or net reclassification when compared with models containing the Pooled Cohort Equations alone.In two independent cohorts, PRS performed similarly to hsCRP for the prediction of CHD risk. These findings suggest PRS does not have unique clinical utility beyond this widely-available, inexpensive measure of risk in unselected middle-aged populations." @default.
- W4385358567 created "2023-07-29" @default.
- W4385358567 creator A5002226085 @default.
- W4385358567 creator A5028895480 @default.
- W4385358567 creator A5067057972 @default.
- W4385358567 creator A5082511859 @default.
- W4385358567 creator A5085451281 @default.
- W4385358567 date "2023-08-01" @default.
- W4385358567 modified "2023-10-17" @default.
- W4385358567 title "Polygenic risk score in comparison with C-reactive protein for predicting incident coronary heart disease" @default.
- W4385358567 cites W1617579864 @default.
- W4385358567 cites W1860487341 @default.
- W4385358567 cites W1968654496 @default.
- W4385358567 cites W2009637031 @default.
- W4385358567 cites W2027340027 @default.
- W4385358567 cites W2035864756 @default.
- W4385358567 cites W2044702943 @default.
- W4385358567 cites W2074847887 @default.
- W4385358567 cites W2083283521 @default.
- W4385358567 cites W2083384274 @default.
- W4385358567 cites W2084139018 @default.
- W4385358567 cites W2096791516 @default.
- W4385358567 cites W2096849439 @default.
- W4385358567 cites W2112316706 @default.
- W4385358567 cites W2125921569 @default.
- W4385358567 cites W2137983259 @default.
- W4385358567 cites W2144504271 @default.
- W4385358567 cites W2144684988 @default.
- W4385358567 cites W2161506768 @default.
- W4385358567 cites W2161633633 @default.
- W4385358567 cites W2168536722 @default.
- W4385358567 cites W2169795969 @default.
- W4385358567 cites W2211287272 @default.
- W4385358567 cites W2222495566 @default.
- W4385358567 cites W2256730325 @default.
- W4385358567 cites W2264523161 @default.
- W4385358567 cites W2288572932 @default.
- W4385358567 cites W2540894735 @default.
- W4385358567 cites W2547395814 @default.
- W4385358567 cites W2549881333 @default.
- W4385358567 cites W2590902687 @default.
- W4385358567 cites W2599627323 @default.
- W4385358567 cites W2731507867 @default.
- W4385358567 cites W2748400555 @default.
- W4385358567 cites W2794819865 @default.
- W4385358567 cites W2886752110 @default.
- W4385358567 cites W2895366584 @default.
- W4385358567 cites W2921012991 @default.
- W4385358567 cites W2944338411 @default.
- W4385358567 cites W2984828313 @default.
- W4385358567 cites W2988296254 @default.
- W4385358567 cites W3001764054 @default.
- W4385358567 cites W3007698544 @default.
- W4385358567 cites W3008788084 @default.
- W4385358567 cites W3087064672 @default.
- W4385358567 cites W3120244012 @default.
- W4385358567 cites W3134721632 @default.
- W4385358567 cites W3193699274 @default.
- W4385358567 cites W3198104045 @default.
- W4385358567 cites W3216708429 @default.
- W4385358567 cites W4200312564 @default.
- W4385358567 cites W4210347219 @default.
- W4385358567 cites W4213133405 @default.
- W4385358567 cites W4223924706 @default.
- W4385358567 cites W4225592358 @default.
- W4385358567 cites W4242416368 @default.
- W4385358567 cites W4285727181 @default.
- W4385358567 cites W4288054362 @default.
- W4385358567 cites W4292553929 @default.
- W4385358567 cites W4310938572 @default.
- W4385358567 cites W4377565526 @default.
- W4385358567 doi "https://doi.org/10.1016/j.atherosclerosis.2023.117194" @default.
- W4385358567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37536150" @default.
- W4385358567 hasPublicationYear "2023" @default.
- W4385358567 type Work @default.
- W4385358567 citedByCount "0" @default.
- W4385358567 crossrefType "journal-article" @default.
- W4385358567 hasAuthorship W4385358567A5002226085 @default.
- W4385358567 hasAuthorship W4385358567A5028895480 @default.
- W4385358567 hasAuthorship W4385358567A5067057972 @default.
- W4385358567 hasAuthorship W4385358567A5082511859 @default.
- W4385358567 hasAuthorship W4385358567A5085451281 @default.
- W4385358567 hasConcept C111815664 @default.
- W4385358567 hasConcept C11783203 @default.
- W4385358567 hasConcept C126322002 @default.
- W4385358567 hasConcept C164705383 @default.
- W4385358567 hasConcept C207103383 @default.
- W4385358567 hasConcept C2776914184 @default.
- W4385358567 hasConcept C2779134260 @default.
- W4385358567 hasConcept C2781195455 @default.
- W4385358567 hasConcept C2908647359 @default.
- W4385358567 hasConcept C44249647 @default.
- W4385358567 hasConcept C500558357 @default.
- W4385358567 hasConcept C50382708 @default.
- W4385358567 hasConcept C71924100 @default.
- W4385358567 hasConcept C72563966 @default.
- W4385358567 hasConcept C99454951 @default.
- W4385358567 hasConceptScore W4385358567C111815664 @default.