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• W4385361444 abstract "Abstract Several hundred mutations are known to cause disease in domestic dogs. Breeding management is therefore required to minimize their spread. Recently, genetic methods such as direct-to-consumer testing have gained popularity, but their effects on dog populations are unclear. Here, we aimed to evaluate the influence of genetic testing on the frequency of mutations causing canine degenerative myelopathy and changes to the genetic structure in the Pembroke Welsh corgi population from Japan. Genetic testing of 5,512 dogs for the causative mutation in SOD1 (c.118G>A (p.E40K)) uncovered a recent decrease in frequency from 14.5% (95/657) in 2019 to 2.9% in 2022 (24/820). Genome-wide single nucleotide polymorphism (SNP) analyses of 117 selected dogs revealed no obvious changes in genetic diversity and inbreeding levels between the 2019 and 2022 populations. Further Fst - based analysis to detect selective pressure identified the signature of 143 SNPs, including an SNP located in the intron of SOD1 adjacent to the c.118G>A mutation. Our study highlights that genetic testing can be supported with improved mating choices in breeding programs to avoid inbreeding. This combined strategy could decrease the genetic risk of canine degenerative myelopathy, a fatal dog disease, and its results would be evident within a few years." @default.
• W4385361444 created "2023-07-29" @default.
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• W4385361444 date "2023-07-26" @default.
• W4385361444 modified "2023-09-23" @default.
• W4385361444 title "Negative selection on a<i>SOD1</i>mutation limits canine degenerative myelopathy while avoiding inbreeding" @default.
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• W4385361444 doi "https://doi.org/10.1101/2023.07.25.550492" @default.
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