FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385362068> ?p ?o ?g. }

• W4385362068 endingPage "1939" @default.
• W4385362068 startingPage "1939" @default.
• W4385362068 abstract "Intravesical immunotherapy with Bacillus Calmette-Guerin (BCG) is a standard of care therapy for non-muscle invasive bladder cancer (NMIBC), which accounts for about 75% of newly diagnosed urothelial cancer. However, given the frequent recurrence and progression, identification of a pre-treatment biomarker capable of predicting responsiveness to BCG in NMIBC is of utmost importance. Herein, using multiparametric flow cytometry, we characterized CD8+ T cells from peripheral blood and tumor tissues collected from 27 pre-BCG patients bearing NMIBC to obtain immune correlates of bladder cancer prognosis and responsiveness to BCG therapy. We observed that intratumoral CD8+ T cell subsets were highly heterogenous in terms of their differentiation state and exist at different proportions in tumor tissues. Remarkably, among the different CD8+ T cell subsets present in the tumor tissues, the frequency of the terminally exhausted-like CD8+ T cell subset, marked as PD1+CD38+Tim3+ CD8+ T cells, was inversely correlated with a favorable outcome for patients and a responsiveness to BCG therapy. Moreover, we also noted that the intratumoral abundance of the progenitor exhausted-like PD1+CD8+ T cell subset in pre-BCG NMIBC tumor tissues was indicative of better recurrence-free survival after BCG. Collectively, our study led to the identification of biomarkers that can predict the therapeutic responsiveness of BCG in NMIBC." @default.
• W4385362068 created "2023-07-29" @default.
• W4385362068 creator A5006276944 @default.
• W4385362068 creator A5009097733 @default.
• W4385362068 creator A5009501609 @default.
• W4385362068 creator A5017474142 @default.
• W4385362068 creator A5019092763 @default.
• W4385362068 creator A5035342417 @default.
• W4385362068 creator A5039286511 @default.
• W4385362068 creator A5041012009 @default.
• W4385362068 creator A5046803655 @default.
• W4385362068 creator A5064923073 @default.
• W4385362068 date "2023-07-26" @default.
• W4385362068 modified "2023-09-26" @default.
• W4385362068 title "Intratumoral PD1+CD38+Tim3+ CD8+ T Cells in Pre-BCG Tumor Tissues Are Associated with Poor Responsiveness to BCG Immunotherapy in Patients with Non-Muscle Invasive Bladder Cancer" @default.
• W4385362068 cites W1709508 @default.
• W4385362068 cites W2001589633 @default.
• W4385362068 cites W2037602993 @default.
• W4385362068 cites W2050607746 @default.
• W4385362068 cites W2058331779 @default.
• W4385362068 cites W2113964885 @default.
• W4385362068 cites W2116195839 @default.
• W4385362068 cites W2119896120 @default.
• W4385362068 cites W2412492782 @default.
• W4385362068 cites W2473162054 @default.
• W4385362068 cites W2506616866 @default.
• W4385362068 cites W2616155686 @default.
• W4385362068 cites W2622957603 @default.
• W4385362068 cites W2737082469 @default.
• W4385362068 cites W2790376750 @default.
• W4385362068 cites W2887935186 @default.
• W4385362068 cites W2889646458 @default.
• W4385362068 cites W2892779818 @default.
• W4385362068 cites W2909486828 @default.
• W4385362068 cites W2939102611 @default.
• W4385362068 cites W3006138994 @default.
• W4385362068 cites W3020888809 @default.
• W4385362068 cites W3030448313 @default.
• W4385362068 cites W3039693333 @default.
• W4385362068 cites W3049244168 @default.
• W4385362068 cites W3120445389 @default.
• W4385362068 cites W3127737538 @default.
• W4385362068 cites W3185265774 @default.
• W4385362068 cites W3186514447 @default.
• W4385362068 cites W4211115520 @default.
• W4385362068 cites W4243650202 @default.
• W4385362068 cites W4295928750 @default.
• W4385362068 doi "https://doi.org/10.3390/cells12151939" @default.
• W4385362068 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37566017" @default.
• W4385362068 hasPublicationYear "2023" @default.
• W4385362068 type Work @default.
• W4385362068 citedByCount "0" @default.
• W4385362068 crossrefType "journal-article" @default.
• W4385362068 hasAuthorship W4385362068A5006276944 @default.
• W4385362068 hasAuthorship W4385362068A5009097733 @default.
• W4385362068 hasAuthorship W4385362068A5009501609 @default.
• W4385362068 hasAuthorship W4385362068A5017474142 @default.
• W4385362068 hasAuthorship W4385362068A5019092763 @default.
• W4385362068 hasAuthorship W4385362068A5035342417 @default.
• W4385362068 hasAuthorship W4385362068A5039286511 @default.
• W4385362068 hasAuthorship W4385362068A5041012009 @default.
• W4385362068 hasAuthorship W4385362068A5046803655 @default.
• W4385362068 hasAuthorship W4385362068A5064923073 @default.
• W4385362068 hasBestOaLocation W43853620681 @default.
• W4385362068 hasConcept C10205521 @default.
• W4385362068 hasConcept C121608353 @default.
• W4385362068 hasConcept C126322002 @default.
• W4385362068 hasConcept C154317977 @default.
• W4385362068 hasConcept C159912055 @default.
• W4385362068 hasConcept C167672396 @default.
• W4385362068 hasConcept C202751555 @default.
• W4385362068 hasConcept C203014093 @default.
• W4385362068 hasConcept C2776090121 @default.
• W4385362068 hasConcept C2777701055 @default.
• W4385362068 hasConcept C2780352672 @default.
• W4385362068 hasConcept C2781197716 @default.
• W4385362068 hasConcept C28328180 @default.
• W4385362068 hasConcept C502942594 @default.
• W4385362068 hasConcept C54355233 @default.
• W4385362068 hasConcept C553184892 @default.
• W4385362068 hasConcept C55493867 @default.
• W4385362068 hasConcept C71924100 @default.
• W4385362068 hasConcept C86803240 @default.
• W4385362068 hasConcept C8891405 @default.
• W4385362068 hasConceptScore W4385362068C10205521 @default.
• W4385362068 hasConceptScore W4385362068C121608353 @default.
• W4385362068 hasConceptScore W4385362068C126322002 @default.
• W4385362068 hasConceptScore W4385362068C154317977 @default.
• W4385362068 hasConceptScore W4385362068C159912055 @default.
• W4385362068 hasConceptScore W4385362068C167672396 @default.
• W4385362068 hasConceptScore W4385362068C202751555 @default.
• W4385362068 hasConceptScore W4385362068C203014093 @default.
• W4385362068 hasConceptScore W4385362068C2776090121 @default.
• W4385362068 hasConceptScore W4385362068C2777701055 @default.
• W4385362068 hasConceptScore W4385362068C2780352672 @default.
• W4385362068 hasConceptScore W4385362068C2781197716 @default.
• W4385362068 hasConceptScore W4385362068C28328180 @default.
• W4385362068 hasConceptScore W4385362068C502942594 @default.

• next