FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385362402> ?p ?o ?g. }

• W4385362402 abstract "Introduction P53 represents a key player in apoptosis-induction in cancers including colorectal cancer (CRC) that ranks third worldwide in cancer prevalence as well as mortality statistics. Although a pro-apoptotic effect of resveratrol has been repeatedly proven in CRC cells, its pathway mechanisms are not completely understood, as there are controversial statements in the literature regarding its activation or inhibition of the counteracting proteins Sirt-1 and p53. Methods CRC cells as wild-type (HCT-116 WT) or p53-deficient (HCT-116 p53 -/- ) were cultured using multicellular tumor microenvironment (TME) cultures containing T-lymphocytes and fibroblasts to elucidate the role of p53/Sirt-1 modulation in resveratrol’s concentration-dependent, pro-apoptotic, and thus anti-cancer effects. Results Resveratrol dose-dependently inhibited viability, proliferation, plasticity as well as migration, and induced apoptosis in HCT-116 WT more effectively than in HCT-116 p53 -/- cells. Moreover, resveratrol stimulated Sirt-1 expression when administered at low concentrations (&lt;5µM) but suppressed it when added at high concentrations (&gt;10µM) to CRC-TME. In parallel, similar to the knockdown of Sirt-1 at the mRNA level, treatment with high-concentration resveratrol boosted the acetylation of p53, the expression of p21, Bax, cytochrome C, caspase-3, and ultimately induced apoptosis in CRC WT but not in CRC p53 -/- cells. Notably, increasing concentrations of resveratrol were found to promote hyperacetylation of p53 and FOXO3a as post-translational substrates of Sirt-1, indicating a negative regulatory loop between Sirt-1 and p53. Discussion These results demonstrate for the first time, a negative reciprocal crosstalk between the regulatory circuits of p53 and Sirt-1, consequently, apoptosis induction by higher resveratrol concentrations in CRC-TME." @default.
• W4385362402 created "2023-07-29" @default.
• W4385362402 creator A5034076477 @default.
• W4385362402 creator A5038295064 @default.
• W4385362402 creator A5072847763 @default.
• W4385362402 creator A5083768693 @default.
• W4385362402 date "2023-07-27" @default.
• W4385362402 modified "2023-09-25" @default.
• W4385362402 title "Resveratrol induces apoptosis by modulating the reciprocal crosstalk between p53 and Sirt-1 in the CRC tumor microenvironment" @default.
• W4385362402 cites W1185768747 @default.
• W4385362402 cites W1803689130 @default.
• W4385362402 cites W1847864430 @default.
• W4385362402 cites W1968786513 @default.
• W4385362402 cites W1974834178 @default.
• W4385362402 cites W1989674299 @default.
• W4385362402 cites W1991755030 @default.
• W4385362402 cites W1992207445 @default.
• W4385362402 cites W2002778248 @default.
• W4385362402 cites W2012053348 @default.
• W4385362402 cites W2023323976 @default.
• W4385362402 cites W2038567590 @default.
• W4385362402 cites W2041568552 @default.
• W4385362402 cites W2047565676 @default.
• W4385362402 cites W2047873654 @default.
• W4385362402 cites W2056564149 @default.
• W4385362402 cites W2059943261 @default.
• W4385362402 cites W2065918661 @default.
• W4385362402 cites W2072342869 @default.
• W4385362402 cites W2075700277 @default.
• W4385362402 cites W2077117930 @default.
• W4385362402 cites W2078805351 @default.
• W4385362402 cites W2078985284 @default.
• W4385362402 cites W2085139923 @default.
• W4385362402 cites W2086680495 @default.
• W4385362402 cites W2088381487 @default.
• W4385362402 cites W2090584945 @default.
• W4385362402 cites W2099907467 @default.
• W4385362402 cites W2101358257 @default.
• W4385362402 cites W2104546896 @default.
• W4385362402 cites W2121431024 @default.
• W4385362402 cites W2123184912 @default.
• W4385362402 cites W2124595934 @default.
• W4385362402 cites W2124898423 @default.
• W4385362402 cites W2132787016 @default.
• W4385362402 cites W2135685233 @default.
• W4385362402 cites W2135849487 @default.
• W4385362402 cites W2140925956 @default.
• W4385362402 cites W2144095565 @default.
• W4385362402 cites W2155972116 @default.
• W4385362402 cites W2158464454 @default.
• W4385362402 cites W2193596268 @default.
• W4385362402 cites W2216972278 @default.
• W4385362402 cites W2291725186 @default.
• W4385362402 cites W2559966901 @default.
• W4385362402 cites W2566076681 @default.
• W4385362402 cites W2767462377 @default.
• W4385362402 cites W2890450868 @default.
• W4385362402 cites W2912193604 @default.
• W4385362402 cites W2913762895 @default.
• W4385362402 cites W2944870444 @default.
• W4385362402 cites W2971677196 @default.
• W4385362402 cites W2982823299 @default.
• W4385362402 cites W3081445244 @default.
• W4385362402 cites W3087632648 @default.
• W4385362402 cites W3090668231 @default.
• W4385362402 cites W3111464951 @default.
• W4385362402 cites W3165720345 @default.
• W4385362402 cites W3190027855 @default.
• W4385362402 cites W3203828395 @default.
• W4385362402 cites W3214983209 @default.
• W4385362402 cites W4220814293 @default.
• W4385362402 cites W4220897376 @default.
• W4385362402 cites W4224859085 @default.
• W4385362402 cites W4225907516 @default.
• W4385362402 cites W4285719527 @default.
• W4385362402 cites W4294219397 @default.
• W4385362402 cites W4323314181 @default.
• W4385362402 doi "https://doi.org/10.3389/fimmu.2023.1225530" @default.
• W4385362402 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37575245" @default.
• W4385362402 hasPublicationYear "2023" @default.
• W4385362402 type Work @default.
• W4385362402 citedByCount "0" @default.
• W4385362402 crossrefType "journal-article" @default.
• W4385362402 hasAuthorship W4385362402A5034076477 @default.
• W4385362402 hasAuthorship W4385362402A5038295064 @default.
• W4385362402 hasAuthorship W4385362402A5072847763 @default.
• W4385362402 hasAuthorship W4385362402A5083768693 @default.
• W4385362402 hasBestOaLocation W43853624021 @default.
• W4385362402 hasConcept C104317684 @default.
• W4385362402 hasConcept C119157956 @default.
• W4385362402 hasConcept C120665830 @default.
• W4385362402 hasConcept C121332964 @default.
• W4385362402 hasConcept C169822122 @default.
• W4385362402 hasConcept C173396325 @default.
• W4385362402 hasConcept C185592680 @default.
• W4385362402 hasConcept C190283241 @default.
• W4385362402 hasConcept C2776107976 @default.
• W4385362402 hasConcept C2776816829 @default.
• W4385362402 hasConcept C3020616263 @default.
• W4385362402 hasConcept C502942594 @default.

• next