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- W4385363665 abstract "<p>Supplementary Data Supplementary Table 1: Key exclusion criteria Supplementary Table 2: Prior systemic therapies Supplementary Table 3: Subsequent anticancer therapy Supplementary Table 4: Mutations by response: cell-of-origin and genetic subtyping Supplementary Table 5: Representativeness of Study Participants Supplementary Figure 1: Study design Supplementary Figure 2: Plasma concentration of danvatirsen, acalabrutinib, and ACP-5862 (active metabolite of acalabrutinib) consistent with historical monotherapy data Supplementary Figure 3: EZB-related mutations by treatment response, number of cycles on treatment, cell-of-origin, and LymphGen cluster Supplementary Figure 4: STAT3 protein and ASO expression detection by IHC Supplementary Figure 5: Allele frequency over time for all patients by response Supplementary Figure 6: Copy number dynamics for all patients with available data by response Supplementary Figure 7: Peripheral blood analysis of gene expression associated with CD19+ B-cell signaling at baseline (A) and for baseline and longitudinal samples (B), and comparison of baseline gene expression of select B- and T-cell–specific genes in PBMCs in responders and nonresponders (C) Supplementary Figure 8: Peripheral blood analysis of gene expression associated with interferon-gamma signaling: baseline comparison (A) and baseline and longitudinal samples (B) Supplementary Figure 9: T-cell, B-cell, and NK-cell (TBNK) flow analysis: immunophenotyping in responders and nonresponders at baseline Supplementary Figure 10: Longitudinal immunophenotyping/immune cell population data (A) and percentage of CD4+ naïve T-cells among all CD4+ T cells (B) at each visit by treatment response Supplementary Figure 11: Pretreatment and on-treatment levels of cytokines/chemokines</p>" @default.
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- W4385363665 date "2023-07-27" @default.
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- W4385363665 title "Supplementary Data 1 from Phase I Study of Acalabrutinib Plus Danvatirsen (AZD9150) in Relapsed/Refractory Diffuse Large B-Cell Lymphoma Including Circulating Tumor DNA Biomarker Assessment" @default.
- W4385363665 doi "https://doi.org/10.1158/1078-0432.23791929" @default.
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