Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385365526> ?p ?o ?g. }
- W4385365526 endingPage "783" @default.
- W4385365526 startingPage "773" @default.
- W4385365526 abstract "Serum lipids were reported to be the prognostic factors of various cancers, but their prognostic value in small cell lung cancer (SCLC) patients remains unclear. This study investigated the relationship between lipid profiles and clinical outcomes in extensive-stage (ES) SCLC by establishing a predictive risk classification model.We retrospectively analyzed the prognostic values of pretreatment serum lipids and their derivatives in patients with a confirmed diagnosis ES-SCLC. Independent factors of progression-free survival (PFS) were determined by univariate and multivariate cox analysis. Then, prognostic nomograms were established, of which predictive performance was evaluated by concordance index (C-index), calibration curves, receiver operating characteristic (ROC) curves, and decision curve analyses (DCA).A total of 158 patients was included in this study. Four optimal PFS-related factors, total cholesterol (TC) ≥ 5.30, high-density lipoprotein cholesterol (HDL-C) > 1.30, triglycerides (TG)/HDL-C > 2.18, and ki67 expression > 70%, were included to construct the predictive nomogram. The C-indexes in training and validation sets were 0.758 and 0.792, respectively. ROC curves, calibration plots, and DCA all suggested favorable discrimination and predictive ability. Besides, the nomogram also performed better predictive ability than ki67 expression. Nomogram-related risk score divided the patients into two groups with significant progression disparities.The promising prognostic nomogram based on lipid parameters could help clinicians to conveniently and accurately evaluate the prognosis of ES-SCLC patients and identify high-risk groups, so as to formulate individualized therapeutic regimens and follow-up strategies in time." @default.
- W4385365526 created "2023-07-29" @default.
- W4385365526 creator A5002907962 @default.
- W4385365526 creator A5037297276 @default.
- W4385365526 creator A5044871527 @default.
- W4385365526 date "2023-07-01" @default.
- W4385365526 modified "2023-09-23" @default.
- W4385365526 title "Analysis of Baseline Serum Lipid Profile for Predicting Clinical Outcomes of Patients with Extensive-Stage Small Cell Lung Cancer" @default.
- W4385365526 cites W1525601333 @default.
- W4385365526 cites W1765976778 @default.
- W4385365526 cites W2056631765 @default.
- W4385365526 cites W2112409006 @default.
- W4385365526 cites W2132836850 @default.
- W4385365526 cites W2516360007 @default.
- W4385365526 cites W2769646213 @default.
- W4385365526 cites W2806995418 @default.
- W4385365526 cites W2887109989 @default.
- W4385365526 cites W2903834179 @default.
- W4385365526 cites W2906981381 @default.
- W4385365526 cites W2944522451 @default.
- W4385365526 cites W3010765451 @default.
- W4385365526 cites W3043543310 @default.
- W4385365526 cites W3080209447 @default.
- W4385365526 cites W3082645444 @default.
- W4385365526 cites W3097949269 @default.
- W4385365526 cites W3114796419 @default.
- W4385365526 cites W3136017577 @default.
- W4385365526 cites W3182160017 @default.
- W4385365526 cites W4214488443 @default.
- W4385365526 cites W4281484186 @default.
- W4385365526 cites W4283725829 @default.
- W4385365526 cites W4291127116 @default.
- W4385365526 cites W4318592053 @default.
- W4385365526 cites W4320495193 @default.
- W4385365526 cites W4323667012 @default.
- W4385365526 cites W4360599760 @default.
- W4385365526 cites W4376121288 @default.
- W4385365526 cites W4377103903 @default.
- W4385365526 cites W4377990925 @default.
- W4385365526 doi "https://doi.org/10.2147/cmar.s418487" @default.
- W4385365526 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37533799" @default.
- W4385365526 hasPublicationYear "2023" @default.
- W4385365526 type Work @default.
- W4385365526 citedByCount "0" @default.
- W4385365526 crossrefType "journal-article" @default.
- W4385365526 hasAuthorship W4385365526A5002907962 @default.
- W4385365526 hasAuthorship W4385365526A5037297276 @default.
- W4385365526 hasAuthorship W4385365526A5044871527 @default.
- W4385365526 hasBestOaLocation W43853655261 @default.
- W4385365526 hasConcept C119857082 @default.
- W4385365526 hasConcept C126322002 @default.
- W4385365526 hasConcept C143998085 @default.
- W4385365526 hasConcept C144301174 @default.
- W4385365526 hasConcept C146357865 @default.
- W4385365526 hasConcept C151730666 @default.
- W4385365526 hasConcept C160798450 @default.
- W4385365526 hasConcept C161584116 @default.
- W4385365526 hasConcept C199163554 @default.
- W4385365526 hasConcept C2776256026 @default.
- W4385365526 hasConcept C2778163477 @default.
- W4385365526 hasConcept C2778270857 @default.
- W4385365526 hasConcept C34626388 @default.
- W4385365526 hasConcept C38180746 @default.
- W4385365526 hasConcept C41008148 @default.
- W4385365526 hasConcept C50382708 @default.
- W4385365526 hasConcept C58471807 @default.
- W4385365526 hasConcept C71924100 @default.
- W4385365526 hasConcept C86803240 @default.
- W4385365526 hasConceptScore W4385365526C119857082 @default.
- W4385365526 hasConceptScore W4385365526C126322002 @default.
- W4385365526 hasConceptScore W4385365526C143998085 @default.
- W4385365526 hasConceptScore W4385365526C144301174 @default.
- W4385365526 hasConceptScore W4385365526C146357865 @default.
- W4385365526 hasConceptScore W4385365526C151730666 @default.
- W4385365526 hasConceptScore W4385365526C160798450 @default.
- W4385365526 hasConceptScore W4385365526C161584116 @default.
- W4385365526 hasConceptScore W4385365526C199163554 @default.
- W4385365526 hasConceptScore W4385365526C2776256026 @default.
- W4385365526 hasConceptScore W4385365526C2778163477 @default.
- W4385365526 hasConceptScore W4385365526C2778270857 @default.
- W4385365526 hasConceptScore W4385365526C34626388 @default.
- W4385365526 hasConceptScore W4385365526C38180746 @default.
- W4385365526 hasConceptScore W4385365526C41008148 @default.
- W4385365526 hasConceptScore W4385365526C50382708 @default.
- W4385365526 hasConceptScore W4385365526C58471807 @default.
- W4385365526 hasConceptScore W4385365526C71924100 @default.
- W4385365526 hasConceptScore W4385365526C86803240 @default.
- W4385365526 hasLocation W43853655261 @default.
- W4385365526 hasLocation W43853655262 @default.
- W4385365526 hasLocation W43853655263 @default.
- W4385365526 hasOpenAccess W4385365526 @default.
- W4385365526 hasPrimaryLocation W43853655261 @default.
- W4385365526 hasRelatedWork W1828158523 @default.
- W4385365526 hasRelatedWork W2082153206 @default.
- W4385365526 hasRelatedWork W2160813944 @default.
- W4385365526 hasRelatedWork W2361144647 @default.
- W4385365526 hasRelatedWork W3146652434 @default.
- W4385365526 hasRelatedWork W4206088420 @default.