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W4385366973 abstract "<p>Supplementary Figure 3: T cell effector functions of TCR-transgenic T cells targeting CICR215W. A. Venn diagram of shared TCR-Î² sequences in T cell lines generated from n = 4 CICR215W vaccinated mice. B. Normalized IFN-Î³ production of different Î{plus minus}-CICR215W TCR candidates transduced in A2.DR1 T cells and re-stimulated with the indicated peptides that were subsequently vaccinated with CICR215W or MOG. C. Normalized IFN-Î³ production of expanded CT2 TCR-transduced T cells incubated with 20 Âµg/ml Î{plus minus}PD-1 and Î{plus minus}CTLA-4 or isotypes and restimulated with CICR215W 27-mer peptide. D. Cell trace far red (CTFR) dilution of CT2 TCR-transduced T cells injected in A2.DR1 recipient mice. E. Representative GFP expression in CD3+ T cells isolated from tumor, contralateral hemisphere (cH), cervical lymph node (cLN) or deep cervical lymph node (dcLN) harvested from A2.DR1 glioma-bearing mice 10 days after adoptive transfer of CT2 Î{plus minus}-CICR215W TCR-transduced T cells. F. Kaplan-Meier curve of A2.DR1 glioma-bearing mice after 2 intraventricular adoptive transfers (AT) of Î{plus minus}CICR215W-TCR T cells and Î{plus minus}Flu-TCR T cells and four doses of ICB (250 Âµg Î{plus minus}PD-1 and 100 Âµg Î{plus minus}CTLA-4 or isotype). n = 9 for CIC, n = 8 for Flu, n = 8 for CIC+ICB and n = 8 for Flu+ICB.</p>" @default.
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W4385366973 date "2023-07-27" @default.
W4385366973 modified "2023-09-27" @default.
W4385366973 title "Figure S3 from T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas" @default.
W4385366973 doi "https://doi.org/10.1158/1078-0432.23791793.v1" @default.
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