FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385368434> ?p ?o ?g. }

• W4385368434 endingPage "1627" @default.
• W4385368434 startingPage "1627" @default.
• W4385368434 abstract "Tacrolimus (TAC) is a narrow-therapeutic-range immunosuppressant drug used after organ transplantation. A therapeutic failure is possible if drug levels are not within the therapeutic range after the first year of treatment. Pharmacogenetic variants and drug–drug interactions (DDIs) are involved. We describe a patient case of a young man (16 years old) with a renal transplant receiving therapy including TAC, mycophenolic acid (MFA), prednisone and omeprazole for prophylaxis of gastric and duodenal ulceration. The patient showed great fluctuation in TAC blood concentration/oral dose ratio, as well as pharmacotherapy adverse effects (AEs) and frequent diarrhea episodes. Additionally, decreased kidney function was found. A pharmacotherapeutic follow-up, including pharmacogenetic analysis, was carried out. The selection of the genes studied was based on the previous literature (CYP3A5, CYP3A4, POR, ABCB1, PXR and CYP2C19). A drug interaction with omeprazole was reported and the nephrologist switched to rabeprazole. A lower TAC concentration/dose ratio was achieved, and the patient’s condition improved. In addition, the TTT haplotype of ATP Binding Cassette Subfamily B member 1 (ABCB1) and Pregnane X Receptor (PXR) gene variants seemed to affect TAC pharmacotherapy in the studied patient and could explain the occurrence of long-term adverse effects post-transplantation. These findings suggest that polymorphic variants and co-treatments must be considered in order to achieve the effectiveness of the immunosuppressive therapy with TAC, especially when polymedicated patients are involved. Moreover, pharmacogenetics could influence the drug concentration at the cellular level, both in lymphocyte and in renal tissue, and should be explored in future studies." @default.
• W4385368434 created "2023-07-29" @default.
• W4385368434 creator A5016287035 @default.
• W4385368434 creator A5033394411 @default.
• W4385368434 creator A5037628345 @default.
• W4385368434 creator A5049175632 @default.
• W4385368434 creator A5066126375 @default.
• W4385368434 creator A5077035142 @default.
• W4385368434 creator A5077461239 @default.
• W4385368434 creator A5086805249 @default.
• W4385368434 date "2023-07-26" @default.
• W4385368434 modified "2023-09-25" @default.
• W4385368434 title "Importance of Pharmacogenetics and Drug–Drug Interactions in a Kidney Transplanted Patient" @default.
• W4385368434 cites W1507788646 @default.
• W4385368434 cites W1565736591 @default.
• W4385368434 cites W158006446 @default.
• W4385368434 cites W1599479195 @default.
• W4385368434 cites W1901692589 @default.
• W4385368434 cites W1968726492 @default.
• W4385368434 cites W1977324053 @default.
• W4385368434 cites W1982285229 @default.
• W4385368434 cites W1988464252 @default.
• W4385368434 cites W1989584074 @default.
• W4385368434 cites W1991347251 @default.
• W4385368434 cites W1998880657 @default.
• W4385368434 cites W2024177850 @default.
• W4385368434 cites W2031138441 @default.
• W4385368434 cites W2033139608 @default.
• W4385368434 cites W2037774211 @default.
• W4385368434 cites W2039400857 @default.
• W4385368434 cites W2049360238 @default.
• W4385368434 cites W2050362026 @default.
• W4385368434 cites W2052331647 @default.
• W4385368434 cites W2054755111 @default.
• W4385368434 cites W2068650301 @default.
• W4385368434 cites W2070827886 @default.
• W4385368434 cites W2082096116 @default.
• W4385368434 cites W2097322998 @default.
• W4385368434 cites W2098535901 @default.
• W4385368434 cites W2105802467 @default.
• W4385368434 cites W2110458924 @default.
• W4385368434 cites W2114062979 @default.
• W4385368434 cites W2142288396 @default.
• W4385368434 cites W2144535667 @default.
• W4385368434 cites W2147312247 @default.
• W4385368434 cites W2148010543 @default.
• W4385368434 cites W2153400906 @default.
• W4385368434 cites W2158246924 @default.
• W4385368434 cites W2159653974 @default.
• W4385368434 cites W2345028093 @default.
• W4385368434 cites W2553275856 @default.
• W4385368434 cites W2574461968 @default.
• W4385368434 cites W2734755699 @default.
• W4385368434 cites W2758462324 @default.
• W4385368434 cites W2793311913 @default.
• W4385368434 cites W2888643550 @default.
• W4385368434 cites W2898643675 @default.
• W4385368434 cites W2903849335 @default.
• W4385368434 cites W2912468140 @default.
• W4385368434 cites W2912602935 @default.
• W4385368434 cites W2995999820 @default.
• W4385368434 cites W3012329627 @default.
• W4385368434 cites W3015401785 @default.
• W4385368434 cites W3045544818 @default.
• W4385368434 cites W3129120915 @default.
• W4385368434 cites W3134333896 @default.
• W4385368434 cites W3208815481 @default.
• W4385368434 cites W3212533536 @default.
• W4385368434 cites W4206989519 @default.
• W4385368434 cites W4210491198 @default.
• W4385368434 cites W4220687844 @default.
• W4385368434 cites W4292860076 @default.
• W4385368434 cites W572729719 @default.
• W4385368434 doi "https://doi.org/10.3390/life13081627" @default.
• W4385368434 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37629484" @default.
• W4385368434 hasPublicationYear "2023" @default.
• W4385368434 type Work @default.
• W4385368434 citedByCount "0" @default.
• W4385368434 crossrefType "journal-article" @default.
• W4385368434 hasAuthorship W4385368434A5016287035 @default.
• W4385368434 hasAuthorship W4385368434A5033394411 @default.
• W4385368434 hasAuthorship W4385368434A5037628345 @default.
• W4385368434 hasAuthorship W4385368434A5049175632 @default.
• W4385368434 hasAuthorship W4385368434A5066126375 @default.
• W4385368434 hasAuthorship W4385368434A5077035142 @default.
• W4385368434 hasAuthorship W4385368434A5077461239 @default.
• W4385368434 hasAuthorship W4385368434A5086805249 @default.
• W4385368434 hasBestOaLocation W43853684341 @default.
• W4385368434 hasConcept C104317684 @default.
• W4385368434 hasConcept C126322002 @default.
• W4385368434 hasConcept C135763542 @default.
• W4385368434 hasConcept C140840227 @default.
• W4385368434 hasConcept C197934379 @default.
• W4385368434 hasConcept C2777498785 @default.
• W4385368434 hasConcept C2778033501 @default.
• W4385368434 hasConcept C2778330430 @default.
• W4385368434 hasConcept C2780035454 @default.
• W4385368434 hasConcept C2780303639 @default.

• next