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- W4385368837 abstract "Viral infections have repeatedly affected human health throughout history, with severe consequences on the well-being of societies. While effective antibacterial activity has been reached with antibiotics, the development of successful antiviral drugs remains challenging, because of the extremely high rates of virus mutations and the frequent outbreaks of new virus species in the human population. Therefore, identification of new strategies to target viruses and the consequent diseases is urgent. G-quadruplexes (G4s) are recognized key regulatory nucelic acids structures in eukaryotic cells. The development of advanced algorithms for G4 prediction greatly expanded research in the G4 field across different species, including viruses. In the past years, increasing evidence showed that the genome of almost all human viruses is enriched in conserved G4-forming sequences, the distribution of which is statistically relevant and distinctive for each virus family. Deeper investigation validated viral G4s as previously unknown regulators of the virus life cycle. The use of available G4 ligands helped discover G4-mediated viral pathways, supporting G4 targeting as an innovative antiviral approach. Here, we describe the state of the art on G4s in different virus families, grouped according to their Baltimore classification. We focus on G4-mediated regulation of the virus life cycle and the antiviral activity of known and developed G4 ligands. We discuss on the feasibility, obstacles, and future perspectives of G4-based antiviral therapies." @default.
- W4385368837 created "2023-07-29" @default.
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- W4385368837 date "2023-01-01" @default.
- W4385368837 modified "2023-10-16" @default.
- W4385368837 title "G-Quadruplexes in Human Viruses: A Promising Route to Innovative Antiviral Therapies" @default.
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- W4385368837 doi "https://doi.org/10.1007/978-981-19-9776-1_81" @default.
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