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- W4385372150 abstract "Abstract Penthorum chinense Pursh ( P. chinense ) has been traditionally used as hepatoprotective food and medicine for hundreds of years due to its significant antioxidant and anti-inflammatory activities. However, the efficacy and mechanisms of action of P. chinense in type 2 diabetes mellitus were not fully understood. In this study, we found that P. chinense extract (PCP) supplementation resulted in reduced body weight and hyperglycemia, improved islet β-cell mitochondrial swelling and insulin sensitivity, and decreased inflammatory cytokines expression in spontaneously diabetic db/db mice. 16S rRNA gene sequencing of fecal samples showed that PCP administration decreased the abundance of Firmicutes and increased the proportion of Bacteroidetes at the phylum level. Moreover, Muribaculum , Barnesiella , Prevotella , and Mucinivorans were enriched, with Desulfovibrio and Lactobacillus lowered at the genus level in db/db mice with PCP supplementation. These results suggested that PCP may ameliorate hyperglycemia, insulin resistance, and inflammation by remodeling the gut microbiota in db/db mice." @default.
- W4385372150 created "2023-07-29" @default.
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- W4385372150 date "2023-07-28" @default.
- W4385372150 modified "2023-10-16" @default.
- W4385372150 title "Penthorum chinense Pursh improves type 2 diabetes mellitus via modulating gut microbiota in db/db mice" @default.
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- W4385372150 doi "https://doi.org/10.21203/rs.3.rs-3134256/v1" @default.
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