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• W4385372804 endingPage "126048" @default.
• W4385372804 startingPage "126048" @default.
• W4385372804 abstract "Nuclear factor kappa-B (NF-κB) pathway is a key mediator of inflammation response that plays a role in host defense for pathogen elimination, but excessive activation may lead to tissue damage or pathogen transmission. The negative regulation of NF-κB in lower vertebrates is largely unknown, hindering further understanding of immune signaling evolution. Here, we provided evidence that Epinephelus coioides soluble toll-like receptor 5 (TLR5S), a member of the TLR5 subfamily, has been newly identified as a negative regulator of NF-κB signaling. EcTLR5S was a cytoplasmic protein consisting of 17 leucine-rich repeat domains, which specifically responded to Vibrio flagellin and suppressed flagellin-induced NF-κB signaling activation and cytokine expression. The amino-terminal LRR 1-5 region was necessary for its negative regulatory function. Dual-luciferase reporter assay showed that EcTLR5S significantly inhibited the NF-κB-luc activity induced by inhibitor of NF-κB kinase α (IKKα) and IKKβ. Subsequently, the functional relationship between EcTLR5M and EcTLR5S was analyzed, revealing that the negative regulatory function of EcTLR5S targeted the activation of the NF-κB pathway mediated by EcTLR5M. The above results reveal that EcTLR5S negatively regulates the flagellin-induced EcTLR5M-NF-κB pathway activation, which may prevent over-activation of immune signaling and restore homeostasis." @default.
• W4385372804 created "2023-07-29" @default.
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• W4385372804 date "2023-09-01" @default.
• W4385372804 modified "2023-10-16" @default.
• W4385372804 title "TLR5S negatively regulates the TLR5M-mediated NF-κB signaling pathway in Epinephelus coioides" @default.
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• W4385372804 doi "https://doi.org/10.1016/j.ijbiomac.2023.126048" @default.
• W4385372804 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37517756" @default.
• W4385372804 hasPublicationYear "2023" @default.
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