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- W4385373353 endingPage "115243" @default.
- W4385373353 startingPage "115243" @default.
- W4385373353 abstract "Brain injury, a common complication in preterm infants, includes the destruction of the key structural and functional connections of the brain and causes neurodevelopmental disorders; it has high morbidity and mortality rates. The exact mechanism underlying brain injury in preterm infants is unclear. Intestinal flora plays a vital role in brain development and the maturation of the immune system in infants; however, detailed understanding of the gut microbiota-metabolite-brain axis in preterm infants is lacking. In this review, we summarise the key mechanisms by which the intestinal microbiota contribute to neurodevelopment and brain injury in preterm infants, with special emphasis on the influence of microorganisms and their metabolites on the regulation of neurocognitive development and neurodevelopmental risks related to preterm birth, infection and neonatal necrotising enterocolitis (NEC). This review provides support for the development and application of novel therapeutic strategies, including probiotics, prebiotics, synbiotics, and faecal bacteria transplantation targeting at brain injury in preterm infants." @default.
- W4385373353 created "2023-07-29" @default.
- W4385373353 creator A5012735472 @default.
- W4385373353 creator A5060810072 @default.
- W4385373353 creator A5072861069 @default.
- W4385373353 creator A5079913874 @default.
- W4385373353 date "2023-09-01" @default.
- W4385373353 modified "2023-09-24" @default.
- W4385373353 title "Role of the gut-microbiota-metabolite-brain axis in the pathogenesis of preterm brain injury" @default.
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