FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385374255> ?p ?o ?g. }

• W4385374255 abstract "Abstract In single-cell RNA sequencing (scRNA-seq) studies, cell-types and their associated marker genes are often identified by clustering and differential expression gene (DEG) analysis. scRNA-seq data contain many genes not relevant to cell-types and gene selection procedures are needed for more accurate clustering. An ideal gene selection procedure should select all DEGs between cell-types for best cell-type identification. However, because cell-types are unknown, gene selection and DEG analysis are performed separately using different methods. Genes are selected using surrogate criteria not directly related with clustering, which often miss important genes or select unimportant genes. Clustering accuracy could be seriously influenced because of the inferior gene selection. DEGs are often detected by comparing different clusters, leading to many false DEGs due to the selection bias problem. In this paper, we present Festem, a unified method for gene selection and DEG analysis in scRNA-seq studies. Festem investigates gene’s clustering information based on the observation that marginal distributions of DEGs are mixtures of their different cell-type-conditional distributions, and can directly select the clustering-informative DEGs and avoid the selection bias problem. Extensive simulation and real data analyses show that Festem achieves high precision and recall for DEG detection, and enables more accurate clustering and cell-type identification. Applications to several scRNA-seq datasets demonstrate that Festem can identify cell-types that are often missed by other methods. In a large intrahepatic cholangiocarcinoma dataset, we identify CD8+ T cell-types and find that their marker genes are novel prognostic biomarkers." @default.
• W4385374255 created "2023-07-29" @default.
• W4385374255 creator A5025109126 @default.
• W4385374255 creator A5055085354 @default.
• W4385374255 creator A5064223990 @default.
• W4385374255 creator A5078729312 @default.
• W4385374255 creator A5090565304 @default.
• W4385374255 date "2023-07-29" @default.
• W4385374255 modified "2023-10-14" @default.
• W4385374255 title "Directly selecting differentially expressed genes for single-cell clustering analyses" @default.
• W4385374255 cites W1483505747 @default.
• W4385374255 cites W1885924565 @default.
• W4385374255 cites W1963740134 @default.
• W4385374255 cites W1970707135 @default.
• W4385374255 cites W1971925780 @default.
• W4385374255 cites W1977556410 @default.
• W4385374255 cites W2042903758 @default.
• W4385374255 cites W2043581384 @default.
• W4385374255 cites W2069089843 @default.
• W4385374255 cites W2106273198 @default.
• W4385374255 cites W2114104545 @default.
• W4385374255 cites W2154598603 @default.
• W4385374255 cites W2163047021 @default.
• W4385374255 cites W2168888135 @default.
• W4385374255 cites W2330210193 @default.
• W4385374255 cites W2332292689 @default.
• W4385374255 cites W2624831627 @default.
• W4385374255 cites W2724543993 @default.
• W4385374255 cites W2753908609 @default.
• W4385374255 cites W2765284830 @default.
• W4385374255 cites W2772325800 @default.
• W4385374255 cites W2774307122 @default.
• W4385374255 cites W2792647356 @default.
• W4385374255 cites W2794480084 @default.
• W4385374255 cites W2897921044 @default.
• W4385374255 cites W2911822431 @default.
• W4385374255 cites W2923426424 @default.
• W4385374255 cites W2950548777 @default.
• W4385374255 cites W2950993016 @default.
• W4385374255 cites W2973156019 @default.
• W4385374255 cites W3007172120 @default.
• W4385374255 cites W3043548051 @default.
• W4385374255 cites W3090590397 @default.
• W4385374255 cites W3111795212 @default.
• W4385374255 cites W3114322636 @default.
• W4385374255 cites W3135159941 @default.
• W4385374255 cites W3161704526 @default.
• W4385374255 cites W4200468913 @default.
• W4385374255 cites W4226106494 @default.
• W4385374255 cites W4250434996 @default.
• W4385374255 cites W4255830679 @default.
• W4385374255 cites W4317708616 @default.
• W4385374255 cites W4328107262 @default.
• W4385374255 cites W4367693164 @default.
• W4385374255 doi "https://doi.org/10.1101/2023.07.26.550670" @default.
• W4385374255 hasPublicationYear "2023" @default.
• W4385374255 type Work @default.
• W4385374255 citedByCount "0" @default.
• W4385374255 crossrefType "posted-content" @default.
• W4385374255 hasAuthorship W4385374255A5025109126 @default.
• W4385374255 hasAuthorship W4385374255A5055085354 @default.
• W4385374255 hasAuthorship W4385374255A5064223990 @default.
• W4385374255 hasAuthorship W4385374255A5078729312 @default.
• W4385374255 hasAuthorship W4385374255A5090565304 @default.
• W4385374255 hasBestOaLocation W43853742551 @default.
• W4385374255 hasConcept C104317684 @default.
• W4385374255 hasConcept C116834253 @default.
• W4385374255 hasConcept C1491633281 @default.
• W4385374255 hasConcept C154945302 @default.
• W4385374255 hasConcept C189014844 @default.
• W4385374255 hasConcept C41008148 @default.
• W4385374255 hasConcept C54355233 @default.
• W4385374255 hasConcept C59822182 @default.
• W4385374255 hasConcept C70721500 @default.
• W4385374255 hasConcept C73555534 @default.
• W4385374255 hasConcept C81917197 @default.
• W4385374255 hasConcept C86803240 @default.
• W4385374255 hasConcept C92835128 @default.
• W4385374255 hasConceptScore W4385374255C104317684 @default.
• W4385374255 hasConceptScore W4385374255C116834253 @default.
• W4385374255 hasConceptScore W4385374255C1491633281 @default.
• W4385374255 hasConceptScore W4385374255C154945302 @default.
• W4385374255 hasConceptScore W4385374255C189014844 @default.
• W4385374255 hasConceptScore W4385374255C41008148 @default.
• W4385374255 hasConceptScore W4385374255C54355233 @default.
• W4385374255 hasConceptScore W4385374255C59822182 @default.
• W4385374255 hasConceptScore W4385374255C70721500 @default.
• W4385374255 hasConceptScore W4385374255C73555534 @default.
• W4385374255 hasConceptScore W4385374255C81917197 @default.
• W4385374255 hasConceptScore W4385374255C86803240 @default.
• W4385374255 hasConceptScore W4385374255C92835128 @default.
• W4385374255 hasLocation W43853742551 @default.
• W4385374255 hasOpenAccess W4385374255 @default.
• W4385374255 hasPrimaryLocation W43853742551 @default.
• W4385374255 hasRelatedWork W2115288517 @default.
• W4385374255 hasRelatedWork W2128227827 @default.
• W4385374255 hasRelatedWork W2783441930 @default.
• W4385374255 hasRelatedWork W2915857439 @default.
• W4385374255 hasRelatedWork W3046385446 @default.
• W4385374255 hasRelatedWork W3163648675 @default.

• next