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- W4385376476 endingPage "126064" @default.
- W4385376476 startingPage "126064" @default.
- W4385376476 abstract "In this study, we synthesized and incorporated chitosan nanoparticles (Cs) into polyhydroxy butyrate (PHB) electrospun scaffolds for cartilage tissue engineering. The Cs nanoparticles were synthesized via an ionic gel interaction between Cs powder and tripolyphosphate (TPP). The mechanical properties, hydrophilicity, and fiber diameter of the PHB scaffolds with varying concentrations of Cs nanoparticles (1-5 wt%) were evaluated. The results of these evaluations showed that the scaffold containing 1 wt% Cs nanoparticles (P1Cs) was the optimum scaffold, with increased ultimate strength from 2.6 to 5.2 MPa and elongation at break from 5.31 % to 12.6 %. Crystallinity, degradation, and cell compatibility were also evaluated. The addition of Cs nanoparticles decreased crystallinity and accelerated hydrolytic degradation. MTT assay results showed that the proliferation of chondrocytes on the scaffold containing 1 wt% Cs nanoparticles were significantly higher than that on pure PHB after 7 days of cultivation. These findings suggest that the electrospun P1Cs scaffold has promising potential as a substrate for cartilage tissue engineering applications. This combination offers a promising approach for the fabrication of biomimetic scaffolds with enhanced mechanical properties, hydrophilicity, and cell compatibility for tissue engineering applications." @default.
- W4385376476 created "2023-07-30" @default.
- W4385376476 creator A5006624396 @default.
- W4385376476 creator A5043313677 @default.
- W4385376476 creator A5043570646 @default.
- W4385376476 creator A5090175637 @default.
- W4385376476 creator A5092565595 @default.
- W4385376476 date "2023-09-01" @default.
- W4385376476 modified "2023-10-01" @default.
- W4385376476 title "Evaluation of the effects of chitosan nanoparticles on polyhydroxy butyrate electrospun scaffolds for cartilage tissue engineering applications" @default.
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- W4385376476 doi "https://doi.org/10.1016/j.ijbiomac.2023.126064" @default.
- W4385376476 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37524286" @default.
- W4385376476 hasPublicationYear "2023" @default.
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