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- W4385379462 abstract "Intestinal edema is a common manifestation of numerous gastrointestinal diseases and is characterized by the accumulation of fluid in the interstitial space of the intestinal wall. Technical advances in laser capture microdissection and low-biomass proteomics now allow us to specifically characterize the intestinal edema proteome. Our data identifies a high abundance of antimicrobial factors, but also highlights major contributions from the blood clotting system, extracellular matrix (ECM) and protease – protease inhibitor networks. The ECM is a complex fibrillar network of macromolecules that provides structural and mechanical support to the intestinal tissue. One abundant component of the ECM observed in the Salmonella-driven intestinal edema is the mechanosensitive glycoprotein fibronectin. Using mechanosensitive staining of fibronectin reveals a solely tensed molecular conformation of fibronectin fibers present in the edema, opposed to other cecal tissue areas, despite the high abundance of proteases able to cleave fibronectin. Co-staining for fibrin(ogen) indicates the formation of a provisional matrix, similar to what is observed in response to skin injury. The absence of low tensional fibronectin fibers and the additional finding of a high number of protease inhibitors in the edema proteome could indicate a critical role of stretched fibronectin fibers in maintaining tissue integrity in the severely inflamed cecum. Understanding these processes may provide valuable functional diagnostic markers of intestinal disease progression." @default.
- W4385379462 created "2023-07-30" @default.
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- W4385379462 date "2023-07-29" @default.
- W4385379462 modified "2023-09-27" @default.
- W4385379462 title "Salmonella-driven Intestinal Edema in Mice is Characterized by Tensed Fibronectin Fibers" @default.
- W4385379462 doi "https://doi.org/10.1101/2023.07.26.550515" @default.
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