FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385380877> ?p ?o ?g. }

• W4385380877 abstract "Abstract We sought to explore the hypothesis that host factors required for HIV-1 replication also play a role in latency reversal. Using a CRISPR gene library of putative HIV dependency factors, we performed a screen to identify genes required for latency reactivation. We identified several HIV-1 dependency factors that play a key role in HIV-1 latency reactivation including ELL , UBE2M , TBL1XR1 , HDAC3 , AMBRA1 , and ALYREF . Knockout of Cyclin T1 ( CCNT1 ), a component of the P-TEFb complex important for transcription elongation, was the top hit in the screen and had the largest effect on HIV latency reversal with a wide variety of latency reversal agents. Moreover, CCNT1 knockout prevents latency reactivation in a primary CD4+ T cell model of HIV latency without affecting activation of these cells. RNA sequencing data showed that CCNT1 regulates HIV-1 proviral genes to a larger extent than any other host gene and had no significant effects on RNA transcripts in primary T cells after activation. We conclude that CCNT1 function is redundant in T cells but is absolutely required for HIV latency reversal." @default.
• W4385380877 created "2023-07-30" @default.
• W4385380877 creator A5009914445 @default.
• W4385380877 creator A5022653646 @default.
• W4385380877 creator A5051442994 @default.
• W4385380877 creator A5059764466 @default.
• W4385380877 creator A5092566636 @default.
• W4385380877 date "2023-07-28" @default.
• W4385380877 modified "2023-10-14" @default.
• W4385380877 title "A CRISPR screen of HIV dependency factors reveals<i>CCNT1</i>is non-essential in T cells but required for HIV-1 reactivation from latency" @default.
• W4385380877 cites W1832413898 @default.
• W4385380877 cites W1964162087 @default.
• W4385380877 cites W1965052314 @default.
• W4385380877 cites W1969097053 @default.
• W4385380877 cites W1971112771 @default.
• W4385380877 cites W1973000551 @default.
• W4385380877 cites W1990125930 @default.
• W4385380877 cites W2002941616 @default.
• W4385380877 cites W2032062642 @default.
• W4385380877 cites W2061432075 @default.
• W4385380877 cites W2072299899 @default.
• W4385380877 cites W2076100163 @default.
• W4385380877 cites W2087966689 @default.
• W4385380877 cites W2088744356 @default.
• W4385380877 cites W2099227836 @default.
• W4385380877 cites W2099300318 @default.
• W4385380877 cites W2100122648 @default.
• W4385380877 cites W2102059779 @default.
• W4385380877 cites W2114104545 @default.
• W4385380877 cites W2114540703 @default.
• W4385380877 cites W2115254768 @default.
• W4385380877 cites W2120285997 @default.
• W4385380877 cites W2124343538 @default.
• W4385380877 cites W2134426654 @default.
• W4385380877 cites W2137586531 @default.
• W4385380877 cites W2151375318 @default.
• W4385380877 cites W2154788828 @default.
• W4385380877 cites W2168127928 @default.
• W4385380877 cites W2169456326 @default.
• W4385380877 cites W2169844526 @default.
• W4385380877 cites W2172295707 @default.
• W4385380877 cites W2179112409 @default.
• W4385380877 cites W2254890159 @default.
• W4385380877 cites W2322237813 @default.
• W4385380877 cites W2333818140 @default.
• W4385380877 cites W2333886848 @default.
• W4385380877 cites W2741508285 @default.
• W4385380877 cites W2782696110 @default.
• W4385380877 cites W2870383488 @default.
• W4385380877 cites W2890675306 @default.
• W4385380877 cites W2901236095 @default.
• W4385380877 cites W2911986456 @default.
• W4385380877 cites W2914889052 @default.
• W4385380877 cites W2928665623 @default.
• W4385380877 cites W2945765453 @default.
• W4385380877 cites W2949242965 @default.
• W4385380877 cites W2951912016 @default.
• W4385380877 cites W2955711170 @default.
• W4385380877 cites W2958467575 @default.
• W4385380877 cites W2969639913 @default.
• W4385380877 cites W2998907312 @default.
• W4385380877 cites W3002913999 @default.
• W4385380877 cites W3013758148 @default.
• W4385380877 cites W3015484735 @default.
• W4385380877 cites W3022827535 @default.
• W4385380877 cites W3110976643 @default.
• W4385380877 cites W3133005041 @default.
• W4385380877 cites W3133584248 @default.
• W4385380877 cites W3160330667 @default.
• W4385380877 cites W3185231148 @default.
• W4385380877 cites W3197950762 @default.
• W4385380877 cites W3203007817 @default.
• W4385380877 cites W4210762403 @default.
• W4385380877 cites W4225492280 @default.
• W4385380877 cites W4225753310 @default.
• W4385380877 cites W4254687493 @default.
• W4385380877 cites W4306816386 @default.
• W4385380877 cites W4313530701 @default.
• W4385380877 cites W4318253732 @default.
• W4385380877 cites W4319294553 @default.
• W4385380877 doi "https://doi.org/10.1101/2023.07.28.551016" @default.
• W4385380877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37546973" @default.
• W4385380877 hasPublicationYear "2023" @default.
• W4385380877 type Work @default.
• W4385380877 citedByCount "0" @default.
• W4385380877 crossrefType "posted-content" @default.
• W4385380877 hasAuthorship W4385380877A5009914445 @default.
• W4385380877 hasAuthorship W4385380877A5022653646 @default.
• W4385380877 hasAuthorship W4385380877A5051442994 @default.
• W4385380877 hasAuthorship W4385380877A5059764466 @default.
• W4385380877 hasAuthorship W4385380877A5092566636 @default.
• W4385380877 hasBestOaLocation W43853808771 @default.
• W4385380877 hasConcept C104317684 @default.
• W4385380877 hasConcept C138885662 @default.
• W4385380877 hasConcept C140704245 @default.
• W4385380877 hasConcept C159047783 @default.
• W4385380877 hasConcept C179926584 @default.
• W4385380877 hasConcept C2522874641 @default.
• W4385380877 hasConcept C2778852064 @default.
• W4385380877 hasConcept C3013748606 @default.

• next