Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385386798> ?p ?o ?g. }
- W4385386798 endingPage "119555" @default.
- W4385386798 startingPage "119555" @default.
- W4385386798 abstract "KIFC1, a member of kinesin-14 subfamily motors, is essential for meiotic cell division and acrosome formation during spermatogenesis. However, the functions of KIFC1 in the formation and maintenance of the acrosome in male germ cells remain to be elucidated. In this study, we report the structural deformities of acrosomes in the in vivo KIFC1 inhibition mouse models. The proacrosomal vesicles diffuse into the cytoplasm and form atypical acrosomal granules. This phenotype is consistent with globozoospermia patients and probably results from the failure of the Golgi-derived vesicle trafficking and actin filament organization. Moreover, the multinucleated and undifferentiated spermatogenic cells in the epidydimal lumen after KIFC1 inhibition reveal the specific roles of KIFC1 in regulating post-meiotic maturation. Overall, our results uncover KIFC1 as an essential regulator in the trafficking, fusion and maturation of acrosomal vesicles during spermiogenesis." @default.
- W4385386798 created "2023-07-30" @default.
- W4385386798 creator A5012776654 @default.
- W4385386798 creator A5016795940 @default.
- W4385386798 creator A5017206665 @default.
- W4385386798 creator A5036664727 @default.
- W4385386798 creator A5083166521 @default.
- W4385386798 creator A5086599682 @default.
- W4385386798 date "2023-10-01" @default.
- W4385386798 modified "2023-10-14" @default.
- W4385386798 title "Kinesin-14 KIFC1 promotes acrosome formation and chromatin maturation during mouse spermiogenesis" @default.
- W4385386798 cites W1542752220 @default.
- W4385386798 cites W1583259478 @default.
- W4385386798 cites W1876415227 @default.
- W4385386798 cites W1970866062 @default.
- W4385386798 cites W1975839137 @default.
- W4385386798 cites W1977794236 @default.
- W4385386798 cites W2002179853 @default.
- W4385386798 cites W2008630334 @default.
- W4385386798 cites W2018532225 @default.
- W4385386798 cites W2025083830 @default.
- W4385386798 cites W2031860536 @default.
- W4385386798 cites W2031976805 @default.
- W4385386798 cites W2037485665 @default.
- W4385386798 cites W2042049004 @default.
- W4385386798 cites W2044798778 @default.
- W4385386798 cites W2045557362 @default.
- W4385386798 cites W2046610500 @default.
- W4385386798 cites W2073300793 @default.
- W4385386798 cites W2077952650 @default.
- W4385386798 cites W2086560719 @default.
- W4385386798 cites W2089816365 @default.
- W4385386798 cites W2094947007 @default.
- W4385386798 cites W2097897485 @default.
- W4385386798 cites W2123272922 @default.
- W4385386798 cites W2142682676 @default.
- W4385386798 cites W2149498732 @default.
- W4385386798 cites W2154933242 @default.
- W4385386798 cites W2155715588 @default.
- W4385386798 cites W2160903957 @default.
- W4385386798 cites W2252403865 @default.
- W4385386798 cites W2342851949 @default.
- W4385386798 cites W2525827236 @default.
- W4385386798 cites W2605337296 @default.
- W4385386798 cites W2627753024 @default.
- W4385386798 cites W2730303405 @default.
- W4385386798 cites W2765566538 @default.
- W4385386798 cites W2911499669 @default.
- W4385386798 cites W2946275167 @default.
- W4385386798 cites W2951674126 @default.
- W4385386798 cites W2952633914 @default.
- W4385386798 cites W2955943801 @default.
- W4385386798 cites W2969331259 @default.
- W4385386798 cites W2969348402 @default.
- W4385386798 cites W2983379256 @default.
- W4385386798 cites W2996950847 @default.
- W4385386798 cites W3014750714 @default.
- W4385386798 cites W3022119306 @default.
- W4385386798 cites W3102041356 @default.
- W4385386798 cites W3108286619 @default.
- W4385386798 cites W3157302647 @default.
- W4385386798 cites W3171895207 @default.
- W4385386798 cites W3175865819 @default.
- W4385386798 cites W3198845041 @default.
- W4385386798 cites W4200450690 @default.
- W4385386798 cites W4220860839 @default.
- W4385386798 cites W4225634771 @default.
- W4385386798 cites W4281553275 @default.
- W4385386798 doi "https://doi.org/10.1016/j.bbamcr.2023.119555" @default.
- W4385386798 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37524262" @default.
- W4385386798 hasPublicationYear "2023" @default.
- W4385386798 type Work @default.
- W4385386798 citedByCount "0" @default.
- W4385386798 crossrefType "journal-article" @default.
- W4385386798 hasAuthorship W4385386798A5012776654 @default.
- W4385386798 hasAuthorship W4385386798A5016795940 @default.
- W4385386798 hasAuthorship W4385386798A5017206665 @default.
- W4385386798 hasAuthorship W4385386798A5036664727 @default.
- W4385386798 hasAuthorship W4385386798A5083166521 @default.
- W4385386798 hasAuthorship W4385386798A5086599682 @default.
- W4385386798 hasConcept C104317684 @default.
- W4385386798 hasConcept C119062480 @default.
- W4385386798 hasConcept C148196450 @default.
- W4385386798 hasConcept C158617107 @default.
- W4385386798 hasConcept C190062978 @default.
- W4385386798 hasConcept C20418707 @default.
- W4385386798 hasConcept C2776053789 @default.
- W4385386798 hasConcept C2778252442 @default.
- W4385386798 hasConcept C2778619154 @default.
- W4385386798 hasConcept C2780723820 @default.
- W4385386798 hasConcept C2781087480 @default.
- W4385386798 hasConcept C54355233 @default.
- W4385386798 hasConcept C86803240 @default.
- W4385386798 hasConcept C95444343 @default.
- W4385386798 hasConceptScore W4385386798C104317684 @default.
- W4385386798 hasConceptScore W4385386798C119062480 @default.
- W4385386798 hasConceptScore W4385386798C148196450 @default.
- W4385386798 hasConceptScore W4385386798C158617107 @default.