Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385389213> ?p ?o ?g. }
- W4385389213 endingPage "115699" @default.
- W4385389213 startingPage "115699" @default.
- W4385389213 abstract "Malaria is among one of the most devastating and deadliest parasitic disease in the world claiming millions of lives every year around the globe. It is a mosquito-borne infectious disease caused by various species of the parasitic protozoan of the genus Plasmodium. The indiscriminate exploitation of the clinically used antimalarial drugs led to the development of various drug-resistant and multidrug-resistant strains of plasmodium which severely reduces the therapeutic effectiveness of most frontline medicines. Therefore, there is urgent need to develop novel structural classes of antimalarial agents acting with unique mechanism of action(s). In this context, design and development of hybrid molecules containing pharmacophoric features of different lead molecules in a single entity represents a unique strategy for the development of next-generation antimalarial drugs. Research efforts by the scientific community over the past few years has led to the identification and development of several heterocyclic small molecules as antimalarial agents with high potency, less toxicity and desired efficacy. Triazole derivatives have become indispensable units in the medicinal chemistry due to their diverse spectrum of biological profiles and many triazole based hybrids and conjugates have demonstrated potential in vitro and in vivo antimalarial activities. The manuscript compiled recent developments in the medicinal chemistry of triazole based small heterocyclic molecules as antimalarial agents and discusses various reported biologically active compounds to lay the groundwork for the rationale design and discovery of triazole based antimalarial compounds. The article emphasised on biological activities, structure activity relationships, and molecular docking studies of various triazole based hybrids with heterocycles such as quinoline, artemisinins, naphthyl, naphthoquinone, etc. as potential antimalarial agents which could act on the dual stage and multi stage of the parasitic life cycle." @default.
- W4385389213 created "2023-07-30" @default.
- W4385389213 creator A5044673310 @default.
- W4385389213 creator A5055137073 @default.
- W4385389213 creator A5082736233 @default.
- W4385389213 creator A5088517372 @default.
- W4385389213 date "2023-11-01" @default.
- W4385389213 modified "2023-10-14" @default.
- W4385389213 title "Current development of 1,2,3-triazole derived potential antimalarial scaffolds: Structure- activity relationship (SAR) and bioactive compounds" @default.
- W4385389213 cites W1839670086 @default.
- W4385389213 cites W1975766044 @default.
- W4385389213 cites W1981162569 @default.
- W4385389213 cites W1982617641 @default.
- W4385389213 cites W1993252763 @default.
- W4385389213 cites W2021650047 @default.
- W4385389213 cites W2026312907 @default.
- W4385389213 cites W2035777452 @default.
- W4385389213 cites W2036287426 @default.
- W4385389213 cites W2039120556 @default.
- W4385389213 cites W2039738410 @default.
- W4385389213 cites W2041896919 @default.
- W4385389213 cites W2051824559 @default.
- W4385389213 cites W2054977369 @default.
- W4385389213 cites W2057089852 @default.
- W4385389213 cites W2058844545 @default.
- W4385389213 cites W2061423144 @default.
- W4385389213 cites W2066931993 @default.
- W4385389213 cites W2073593256 @default.
- W4385389213 cites W2090656304 @default.
- W4385389213 cites W2094290852 @default.
- W4385389213 cites W2102131955 @default.
- W4385389213 cites W2109863545 @default.
- W4385389213 cites W2114774724 @default.
- W4385389213 cites W2125677289 @default.
- W4385389213 cites W2135700462 @default.
- W4385389213 cites W2315479558 @default.
- W4385389213 cites W2408851928 @default.
- W4385389213 cites W2467038324 @default.
- W4385389213 cites W2519141520 @default.
- W4385389213 cites W2521923472 @default.
- W4385389213 cites W2533019245 @default.
- W4385389213 cites W2537724458 @default.
- W4385389213 cites W2546422487 @default.
- W4385389213 cites W2608011451 @default.
- W4385389213 cites W2619165690 @default.
- W4385389213 cites W2738136055 @default.
- W4385389213 cites W2749891110 @default.
- W4385389213 cites W2761931160 @default.
- W4385389213 cites W2782539068 @default.
- W4385389213 cites W2782697776 @default.
- W4385389213 cites W2789898832 @default.
- W4385389213 cites W2792054227 @default.
- W4385389213 cites W2792267843 @default.
- W4385389213 cites W2807932563 @default.
- W4385389213 cites W2809613680 @default.
- W4385389213 cites W2887868855 @default.
- W4385389213 cites W2890950141 @default.
- W4385389213 cites W2903916649 @default.
- W4385389213 cites W2907662009 @default.
- W4385389213 cites W2911537834 @default.
- W4385389213 cites W2914146788 @default.
- W4385389213 cites W2915026506 @default.
- W4385389213 cites W2936932034 @default.
- W4385389213 cites W2944101234 @default.
- W4385389213 cites W2946629075 @default.
- W4385389213 cites W2949647588 @default.
- W4385389213 cites W2951968884 @default.
- W4385389213 cites W2954167186 @default.
- W4385389213 cites W2982244622 @default.
- W4385389213 cites W2982387087 @default.
- W4385389213 cites W2987725683 @default.
- W4385389213 cites W2990430418 @default.
- W4385389213 cites W3003363388 @default.
- W4385389213 cites W3009238373 @default.
- W4385389213 cites W3011457282 @default.
- W4385389213 cites W3022591587 @default.
- W4385389213 cites W3022763925 @default.
- W4385389213 cites W3039029272 @default.
- W4385389213 cites W3042953397 @default.
- W4385389213 cites W3047185954 @default.
- W4385389213 cites W3048041047 @default.
- W4385389213 cites W3049730024 @default.
- W4385389213 cites W3058847565 @default.
- W4385389213 cites W3089619155 @default.
- W4385389213 cites W3091045111 @default.
- W4385389213 cites W3101580048 @default.
- W4385389213 cites W3103316846 @default.
- W4385389213 cites W3108018172 @default.
- W4385389213 cites W3110718577 @default.
- W4385389213 cites W3110806419 @default.
- W4385389213 cites W3126347496 @default.
- W4385389213 cites W3129743096 @default.
- W4385389213 cites W3134255092 @default.
- W4385389213 cites W3135152601 @default.
- W4385389213 cites W3136444228 @default.
- W4385389213 cites W3137151194 @default.
- W4385389213 cites W3164003588 @default.
- W4385389213 cites W3165094801 @default.