FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385394460> ?p ?o ?g. }

• W4385394460 abstract "Aspirin is one of the most commonly used drugs worldwide. It is known to present antipyretic, anti-inflammatory and anti-thrombotic actions, making it extremely useful in a wide range of clinical contexts. Interestingly, homeopathically prepared Aspirin 15cH has been found to have a pro-thrombotic effect in rats, raising the hypothesis that Aspirin 15cH could also modulate the activity of inflammatory cells in different pathological processes. Our objective was to assess what effect Aspirin 15cH has on RAW 264.7 macrophages in vitro. The effects of Aspirin 15cH on biochemical and morphological activities of lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages were evaluated. These effects were compared with unchallenged macrophages (negative control), untreated LPS-stimulated macrophages, macrophages treated with succussed water (vehicle control), or aspirin 200 µg/mL (pharmacological inhibitor of LPS activity). Cell morphology (adhered cell area and cytoskeleton arrangements), cell viability, toll-like receptor-4 (TLR-4) expression, and the production of nitric oxide, cytokines and intracellular reactive oxygen species were assessed. Aspirin 15cH reduced the number of cells expressing TLR-4 on the surface (p = 0.03) and induced a columnar morphology of macrophage pseudopods, indicating changes in cytoskeleton arrangement. When cells were treated with both Aspirin 15cH and LPS, cell morphology became heterogeneous, suggesting that sub-populations of cells had differing sensitivities to LPS or Aspirin 15cH. Exposure of the cells to LPS alone, succussed water or aspirin 200 µg/mL produced effects consistent with the literature. Aspirin 15cH, aspirin 200 µg/mL, LPS and succussed water appear to act as independent stimuli able to induce different patterns of macrophage response. Aspirin 15cH induced changes suggestive of M2 polarization of the macrophages (i.e., toward a wound healing or tissue repair, rather than inflammatory, phenotype). These preliminary findings need to be confirmed in further specific studies." @default.
• W4385394460 created "2023-07-31" @default.
• W4385394460 creator A5002309918 @default.
• W4385394460 creator A5008299614 @default.
• W4385394460 creator A5015826109 @default.
• W4385394460 creator A5024294809 @default.
• W4385394460 creator A5040899080 @default.
• W4385394460 creator A5059269851 @default.
• W4385394460 creator A5087740044 @default.
• W4385394460 creator A5092570018 @default.
• W4385394460 creator A5092570019 @default.
• W4385394460 date "2023-07-30" @default.
• W4385394460 modified "2023-10-06" @default.
• W4385394460 title "Aspirin 15cH has Different Effects on Morphology and Function of Lipopolysaccharide-Challenged RAW 264.7 Macrophages In Vitro Compared to a Pharmacological Dose of Aspirin" @default.
• W4385394460 cites W1975894353 @default.
• W4385394460 cites W1976783282 @default.
• W4385394460 cites W1983321974 @default.
• W4385394460 cites W1986064116 @default.
• W4385394460 cites W2012871131 @default.
• W4385394460 cites W2016699607 @default.
• W4385394460 cites W2017247118 @default.
• W4385394460 cites W2026437687 @default.
• W4385394460 cites W2026527446 @default.
• W4385394460 cites W2030564522 @default.
• W4385394460 cites W2030606033 @default.
• W4385394460 cites W2031390211 @default.
• W4385394460 cites W2068309254 @default.
• W4385394460 cites W2073972118 @default.
• W4385394460 cites W2081370548 @default.
• W4385394460 cites W2081403995 @default.
• W4385394460 cites W2081677211 @default.
• W4385394460 cites W2100128950 @default.
• W4385394460 cites W2112568072 @default.
• W4385394460 cites W2134887846 @default.
• W4385394460 cites W2138591857 @default.
• W4385394460 cites W2140443090 @default.
• W4385394460 cites W2169613595 @default.
• W4385394460 cites W2170301701 @default.
• W4385394460 cites W2183465443 @default.
• W4385394460 cites W2185552766 @default.
• W4385394460 cites W2222046008 @default.
• W4385394460 cites W2266539045 @default.
• W4385394460 cites W2528491208 @default.
• W4385394460 cites W2548267659 @default.
• W4385394460 cites W2567468286 @default.
• W4385394460 cites W2726685122 @default.
• W4385394460 cites W2755108214 @default.
• W4385394460 cites W2756420607 @default.
• W4385394460 cites W2773400399 @default.
• W4385394460 cites W2777876184 @default.
• W4385394460 cites W2784315882 @default.
• W4385394460 cites W2789733077 @default.
• W4385394460 cites W2800856665 @default.
• W4385394460 cites W2807721837 @default.
• W4385394460 cites W2892288854 @default.
• W4385394460 cites W2912663500 @default.
• W4385394460 cites W2922787085 @default.
• W4385394460 cites W2937499220 @default.
• W4385394460 cites W2939165166 @default.
• W4385394460 cites W2953857717 @default.
• W4385394460 cites W2963918876 @default.
• W4385394460 cites W2964621133 @default.
• W4385394460 cites W3024102246 @default.
• W4385394460 cites W3113344283 @default.
• W4385394460 cites W3134243233 @default.
• W4385394460 cites W3164982115 @default.
• W4385394460 cites W3170936217 @default.
• W4385394460 cites W4213358220 @default.
• W4385394460 cites W4285793795 @default.
• W4385394460 cites W4306782533 @default.
• W4385394460 doi "https://doi.org/10.1055/s-0043-1769105" @default.
• W4385394460 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37517405" @default.
• W4385394460 hasPublicationYear "2023" @default.
• W4385394460 type Work @default.
• W4385394460 citedByCount "0" @default.
• W4385394460 crossrefType "journal-article" @default.
• W4385394460 hasAuthorship W4385394460A5002309918 @default.
• W4385394460 hasAuthorship W4385394460A5008299614 @default.
• W4385394460 hasAuthorship W4385394460A5015826109 @default.
• W4385394460 hasAuthorship W4385394460A5024294809 @default.
• W4385394460 hasAuthorship W4385394460A5040899080 @default.
• W4385394460 hasAuthorship W4385394460A5059269851 @default.
• W4385394460 hasAuthorship W4385394460A5087740044 @default.
• W4385394460 hasAuthorship W4385394460A5092570018 @default.
• W4385394460 hasAuthorship W4385394460A5092570019 @default.
• W4385394460 hasConcept C185592680 @default.
• W4385394460 hasConcept C202751555 @default.
• W4385394460 hasConcept C203014093 @default.
• W4385394460 hasConcept C2777628954 @default.
• W4385394460 hasConcept C2778754761 @default.
• W4385394460 hasConcept C2779244956 @default.
• W4385394460 hasConcept C2779252780 @default.
• W4385394460 hasConcept C2780820201 @default.
• W4385394460 hasConcept C55493867 @default.
• W4385394460 hasConcept C71924100 @default.
• W4385394460 hasConcept C98274493 @default.
• W4385394460 hasConceptScore W4385394460C185592680 @default.
• W4385394460 hasConceptScore W4385394460C202751555 @default.
• W4385394460 hasConceptScore W4385394460C203014093 @default.
• W4385394460 hasConceptScore W4385394460C2777628954 @default.

• next