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- W4385398013 abstract "Type 2 diabetes (T2D) patients have poorer outcomes post-myocardial ischaemia/reperfusion (I/R) injury, where the heart switches from aerobic to anaerobic metabolism. The heart eases the burden of this switch by relying on creatine (Cr) and phosphocreatine (PCr) to replenish its ATP stores. During coronary artery bypass surgery, exogenous PCr can improve myocardial contractility post-I/R injury. The multi-step production of endogenous Cr involves the liver and kidney, which can be impacted by T2D-related non-alcoholic fatty liver disease (NAFLD) and diabetic glomerulosclerosis. However, the effect of T2D on endogenous Cr synthesis is unclear. Thus, this study investigated the interplay between diabetic cardiomyopathy, T2D-related NAFLD, and diabetic glomerulosclerosis." @default.
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- W4385398013 date "2023-07-01" @default.
- W4385398013 modified "2023-09-29" @default.
- W4385398013 title "Type 2 Diabetes and the Hepatic-Cardiac Nexus: The Role of Endogenous Creatine Synthesis in Diabetic Cardiomyopathy" @default.
- W4385398013 doi "https://doi.org/10.1016/j.hlc.2023.06.137" @default.
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