FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385407086> ?p ?o ?g. }

• W4385407086 endingPage "755" @default.
• W4385407086 startingPage "743" @default.
• W4385407086 abstract "Aims Epithelioid haemangioma (EH) of bone remains a highly controversial entity. Indeed, the WHO classifies EHs of soft tissues as benign tumours, whereas bone EHs are considered intermediate–locally aggressive tumours due to common multifocal presentation and local destructive growth. To gain insights into the clinical behaviour and biology of EH of bone we retrospectively analysed 42 patients treated in a single institution from 1978 to 2021. Methods and results Multifocal presentation was detected in 17 of 42 patients (40%) primarily as synchronous lesions. Patients were treated with curettage (57%), resection (29%) or biopsy, followed by radiotherapy or embolisation (14%). Follow‐up (minimum 24 months) was available for 38 patients, with only five local recurrences (13%) and no death of disease. To clarify whether the synchronous bone lesions in multifocal EH represent multicentric disease or clonal dissemination, four cases were profiled by RNA‐sequencing. Separate lesions from the same patient, which showed a similar transcriptional profile, expressed the same fusion transcript (involving FOS or FOSB) with identical gene breakpoints. Conclusions These results indicate that, in EH of bone, multifocal lesions are clonally related and therefore represent the spread of a same neoplastic clone rather than simultaneous independent tumours. This finding is in apparent contradiction with the benign clinical course of the disease, and suggests that tumour dissemination in bone EH probably reflects a phenomenon of passive spreading, with tumour cells colonising distal sites while maintaining their benign biological nature." @default.
• W4385407086 created "2023-08-01" @default.
• W4385407086 creator A5005486608 @default.
• W4385407086 creator A5011487326 @default.
• W4385407086 creator A5015966863 @default.
• W4385407086 creator A5016029748 @default.
• W4385407086 creator A5018685447 @default.
• W4385407086 creator A5024463077 @default.
• W4385407086 creator A5026365583 @default.
• W4385407086 creator A5038363728 @default.
• W4385407086 creator A5042126282 @default.
• W4385407086 creator A5056098709 @default.
• W4385407086 creator A5070383055 @default.
• W4385407086 creator A5073052848 @default.
• W4385407086 creator A5074222525 @default.
• W4385407086 date "2023-07-30" @default.
• W4385407086 modified "2023-10-17" @default.
• W4385407086 title "Fusion transcriptome profiling defines the monoclonal origin of multifocal epithelioid haemangioma of bone" @default.
• W4385407086 cites W1931360432 @default.
• W4385407086 cites W1940831899 @default.
• W4385407086 cites W1991756923 @default.
• W4385407086 cites W1999004800 @default.
• W4385407086 cites W1999574084 @default.
• W4385407086 cites W2021542512 @default.
• W4385407086 cites W2022582843 @default.
• W4385407086 cites W2024331903 @default.
• W4385407086 cites W2054796813 @default.
• W4385407086 cites W2066649669 @default.
• W4385407086 cites W2139822082 @default.
• W4385407086 cites W2142416414 @default.
• W4385407086 cites W2149926770 @default.
• W4385407086 cites W2156439133 @default.
• W4385407086 cites W2169456326 @default.
• W4385407086 cites W2179438025 @default.
• W4385407086 cites W2340944150 @default.
• W4385407086 cites W2413738313 @default.
• W4385407086 cites W2742618946 @default.
• W4385407086 cites W2769690313 @default.
• W4385407086 cites W2922233759 @default.
• W4385407086 cites W2970758407 @default.
• W4385407086 cites W3015954294 @default.
• W4385407086 cites W3016152300 @default.
• W4385407086 cites W3091880572 @default.
• W4385407086 cites W3092603834 @default.
• W4385407086 cites W3111061871 @default.
• W4385407086 cites W3118238647 @default.
• W4385407086 cites W4233750857 @default.
• W4385407086 cites W4247848899 @default.
• W4385407086 cites W4247974440 @default.
• W4385407086 cites W4292253343 @default.
• W4385407086 cites W4312010814 @default.
• W4385407086 doi "https://doi.org/10.1111/his.15016" @default.
• W4385407086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37519041" @default.
• W4385407086 hasPublicationYear "2023" @default.
• W4385407086 type Work @default.
• W4385407086 citedByCount "0" @default.
• W4385407086 crossrefType "journal-article" @default.
• W4385407086 hasAuthorship W4385407086A5005486608 @default.
• W4385407086 hasAuthorship W4385407086A5011487326 @default.
• W4385407086 hasAuthorship W4385407086A5015966863 @default.
• W4385407086 hasAuthorship W4385407086A5016029748 @default.
• W4385407086 hasAuthorship W4385407086A5018685447 @default.
• W4385407086 hasAuthorship W4385407086A5024463077 @default.
• W4385407086 hasAuthorship W4385407086A5026365583 @default.
• W4385407086 hasAuthorship W4385407086A5038363728 @default.
• W4385407086 hasAuthorship W4385407086A5042126282 @default.
• W4385407086 hasAuthorship W4385407086A5056098709 @default.
• W4385407086 hasAuthorship W4385407086A5070383055 @default.
• W4385407086 hasAuthorship W4385407086A5073052848 @default.
• W4385407086 hasAuthorship W4385407086A5074222525 @default.
• W4385407086 hasBestOaLocation W43854070861 @default.
• W4385407086 hasConcept C142724271 @default.
• W4385407086 hasConcept C2775934546 @default.
• W4385407086 hasConcept C2779904257 @default.
• W4385407086 hasConcept C71924100 @default.
• W4385407086 hasConcept C86803240 @default.
• W4385407086 hasConceptScore W4385407086C142724271 @default.
• W4385407086 hasConceptScore W4385407086C2775934546 @default.
• W4385407086 hasConceptScore W4385407086C2779904257 @default.
• W4385407086 hasConceptScore W4385407086C71924100 @default.
• W4385407086 hasConceptScore W4385407086C86803240 @default.
• W4385407086 hasFunder F4320321781 @default.
• W4385407086 hasFunder F4320323054 @default.
• W4385407086 hasIssue "5" @default.
• W4385407086 hasLocation W43854070861 @default.
• W4385407086 hasLocation W43854070862 @default.
• W4385407086 hasOpenAccess W4385407086 @default.
• W4385407086 hasPrimaryLocation W43854070861 @default.
• W4385407086 hasRelatedWork W1506200166 @default.
• W4385407086 hasRelatedWork W1995515455 @default.
• W4385407086 hasRelatedWork W2048182022 @default.
• W4385407086 hasRelatedWork W2080531066 @default.
• W4385407086 hasRelatedWork W2604872355 @default.
• W4385407086 hasRelatedWork W2748952813 @default.
• W4385407086 hasRelatedWork W2899084033 @default.
• W4385407086 hasRelatedWork W3031052312 @default.
• W4385407086 hasRelatedWork W3032375762 @default.
• W4385407086 hasRelatedWork W3108674512 @default.

• next