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• W4385408033 endingPage "1733" @default.
• W4385408033 startingPage "1720" @default.
• W4385408033 abstract "Abstract Autophagy functions in cellular quality control and metabolic regulation. Dysregulation of autophagy is one of the major pathogenic factors contributing to the progression of nonalcoholic fatty liver disease (NAFLD). Autophagy is involved in the breakdown of intracellular lipids and the maintenance of healthy mitochondria in NAFLD. However, the mechanisms underlying autophagy dysregulation in NAFLD remain unclear. Here, we demonstrate that the hepatic expression level of Thrap3 was significantly increased in NAFLD conditions. Liver-specific Thrap3 knockout improved lipid accumulation and metabolic properties in a high-fat diet (HFD)-induced NAFLD model. Furthermore, Thrap3 deficiency enhanced autophagy and mitochondrial function. Interestingly, Thrap3 knockout increased the cytosolic translocation of AMPK from the nucleus and enhanced its activation through physical interaction. The translocation of AMPK was regulated by direct binding with AMPK and the C-terminal domain of Thrap3. Our results indicate a role for Thrap3 in NAFLD progression and suggest that Thrap3 is a potential target for NAFLD treatment." @default.
• W4385408033 created "2023-08-01" @default.
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• W4385408033 date "2023-08-01" @default.
• W4385408033 modified "2023-10-17" @default.
• W4385408033 title "Thrap3 promotes nonalcoholic fatty liver disease by suppressing AMPK-mediated autophagy" @default.
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• W4385408033 cites W1977767269 @default.
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• W4385408033 doi "https://doi.org/10.1038/s12276-023-01047-4" @default.
• W4385408033 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37524868" @default.
• W4385408033 hasPublicationYear "2023" @default.
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