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- W4385408384 abstract "The present study aims to explore the local spatiotemporal consistency of brain connectivity in PD patients. In total, 30 PD patients and 20 health controls (HC) were collected from the Parkinson’s progression markers initiative (PPMI) and their resting state functional MRI images are acquired. FOur-dimensional Consistency of local neural Activities (FOCA) was employed for the first time to explore local brain activity differences between the two groups. To explore the relationship between FOCA values and neuropsychological indices, the Pearson correlation analysis was performed. And receiver operating characteristic (ROC) analysis was carried out to distinguish PD from HC. Compared with HC, PD patients demonstrated decreased FOCA values in the right inferior temporal gyrus (ITG.R), right middle temporal gyrus (MTG.R), right middle occipital gyrus (MOG.R), right superior occipital gyrus, right inferior occipital gyrus, left precentral gyrus (PreCG.L), left postcentral gyrus (PoCG.L) and left rolandic operculum. The FOCA values in MTG.R and ITG.R were positively related to Montreal Cognitive Assessment (MoCA) values. Negative relationships had been found in FOCA values of PreCG.L and MOG.R and Unified Parkinson’s Disease Rating Scale (UPDRS) III scores. What’s more, the ROC analysis showed that the FOCA values of altered brain regions can be used to distinguish PD patients from HC with high performance. PD patients demonstrated disrupted local brain activity in several brain regions. These brain regions are mainly involved in motor, cognitive and emotional functions. The current study provides important insights into understanding the pathophysiological mechanism of PD symptoms." @default.
- W4385408384 created "2023-08-01" @default.
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- W4385408384 date "2023-08-01" @default.
- W4385408384 modified "2023-09-27" @default.
- W4385408384 title "Altered spatiotemporal consistency of local neural activities in Parkinson's disease" @default.
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- W4385408384 doi "https://doi.org/10.1117/12.2689212" @default.
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