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Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385408831> ?p ?o ?g. }

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• W4385408831 abstract "We here introduce a novel bioreducible polymer-based gene delivery platform enabling widespread transgene expression in multiple brain regions with therapeutic relevance following intracranial convection-enhanced delivery. Our bioreducible nanoparticles provide markedly enhanced gene delivery efficacy in vitro and in vivo compared to nonbiodegradable nanoparticles primarily due to the ability to release gene payloads preferentially inside cells. Remarkably, our platform exhibits competitive gene delivery efficacy in a neuron-rich brain region compared to a viral vector under previous and current clinical investigations with demonstrated positive outcomes. Thus, our platform may serve as an attractive alternative for the intracranial gene therapy of neurological disorders." @default.
• W4385408831 created "2023-08-01" @default.
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• W4385408831 date "2023-07-31" @default.
• W4385408831 modified "2023-10-15" @default.
• W4385408831 title "Bioreducible Gene Delivery Platform that Promotes Intracellular Payload Release and Widespread Brain Dispersion" @default.
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• W4385408831 doi "https://doi.org/10.1021/acsbiomaterials.3c00799" @default.
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• W4385408831 hasPublicationYear "2023" @default.
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