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- W4385409148 abstract "ABSTRACT The structure of chromatin at the nucleosome level inside cells is mysterious. Here we present in situ cryo-ET analyses of chromatin in both G1 and metaphase RPE-1 cells. G1 nucleosomes are concentrated in globular chromatin domains and metaphase nucleosomes are concentrated in the chromatids. Classification analysis reveals that canonical mononucleosomes, ordered stacked dinucleosomes, and mononucleosomes with a disordered gyre-proximal density are abundant in both cell-cycle states. Class averages that have more than two stacked nucleosomes or that have side-by-side dinucleosomes are not detected, suggesting that groups of more than two nucleosomes are heterogeneous. Large multi-megadalton structures are abundant in G1 nucleoplasm, but not found in G1 chromatin domains and metaphase chromatin. The macromolecular phenotypes studied here represent a starting point for the comparative analysis of condensation in normal and unhealthy human cells, in other cell-cycle states, other organisms, and in vitro chromatin assemblies." @default.
- W4385409148 created "2023-08-01" @default.
- W4385409148 creator A5010176687 @default.
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- W4385409148 creator A5082969987 @default.
- W4385409148 date "2023-07-31" @default.
- W4385409148 modified "2023-09-27" @default.
- W4385409148 title "Nanoscale analysis of human G1 and metaphase chromatin in situ" @default.
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