FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385409825> ?p ?o ?g. }

• W4385409825 abstract "The 70-kD heat shock protein (Hsp70) chaperone system is a central hub of the proteostasis network that helps maintain protein homeostasis in all organisms. The recruitment of Hsp70 to perform different and specific cellular functions is regulated by the J-domain protein (JDP) co-chaperone family carrying the small namesake J-domain, required to interact and drive the ATPase cycle of Hsp70s. Besides the J-domain, prokaryotic and eukaryotic JDPs display a staggering diversity in domain architecture, function, and cellular localization. Very little is known about the overall JDP family, despite their essential role in cellular proteostasis, development, and its link to a broad range of human diseases. In this work, we leverage the exponentially increasing number of JDP gene sequences identified across all kingdoms owing to the advancements in sequencing technology and provide a broad overview of the JDP repertoire. Using an automated classification scheme based on artificial neural networks (ANNs), we demonstrate that the sequences of J-domains carry sufficient discriminatory information to reliably recover the phylogeny, localization, and domain composition of the corresponding full-length JDP. By harnessing the interpretability of the ANNs, we find that many of the discriminatory sequence positions match residues that form the interaction interface between the J-domain and Hsp70. This reveals that key residues within the J-domains have coevolved with their obligatory Hsp70 partners to build chaperone circuits for specific functions in cells." @default.
• W4385409825 created "2023-08-01" @default.
• W4385409825 creator A5028283040 @default.
• W4385409825 creator A5044273102 @default.
• W4385409825 creator A5044840019 @default.
• W4385409825 creator A5055873619 @default.
• W4385409825 creator A5072168949 @default.
• W4385409825 creator A5079783310 @default.
• W4385409825 date "2023-07-31" @default.
• W4385409825 modified "2023-09-30" @default.
• W4385409825 title "Data-driven large-scale genomic analysis reveals an intricate phylogenetic and functional landscape in J-domain proteins" @default.
• W4385409825 cites W1629913048 @default.
• W4385409825 cites W1972121275 @default.
• W4385409825 cites W1972980743 @default.
• W4385409825 cites W1980772064 @default.
• W4385409825 cites W1985879346 @default.
• W4385409825 cites W1991526269 @default.
• W4385409825 cites W1993425144 @default.
• W4385409825 cites W1995112257 @default.
• W4385409825 cites W1999815303 @default.
• W4385409825 cites W2002614368 @default.
• W4385409825 cites W2002782099 @default.
• W4385409825 cites W2004012884 @default.
• W4385409825 cites W2015607954 @default.
• W4385409825 cites W2024243591 @default.
• W4385409825 cites W2030813770 @default.
• W4385409825 cites W2036604732 @default.
• W4385409825 cites W2041660879 @default.
• W4385409825 cites W2051563344 @default.
• W4385409825 cites W2055917344 @default.
• W4385409825 cites W2062837921 @default.
• W4385409825 cites W2062992011 @default.
• W4385409825 cites W2063502932 @default.
• W4385409825 cites W2064878094 @default.
• W4385409825 cites W2073376872 @default.
• W4385409825 cites W2074593513 @default.
• W4385409825 cites W2084351833 @default.
• W4385409825 cites W2084604716 @default.
• W4385409825 cites W2088305244 @default.
• W4385409825 cites W2092340914 @default.
• W4385409825 cites W2099234264 @default.
• W4385409825 cites W2102652793 @default.
• W4385409825 cites W2110913873 @default.
• W4385409825 cites W2111731625 @default.
• W4385409825 cites W2127774996 @default.
• W4385409825 cites W2131294770 @default.
• W4385409825 cites W2135621733 @default.
• W4385409825 cites W2135880722 @default.
• W4385409825 cites W2137566700 @default.
• W4385409825 cites W2141727756 @default.
• W4385409825 cites W2150815282 @default.
• W4385409825 cites W2214677303 @default.
• W4385409825 cites W2395745621 @default.
• W4385409825 cites W2473839281 @default.
• W4385409825 cites W2518363707 @default.
• W4385409825 cites W2522058963 @default.
• W4385409825 cites W2558412931 @default.
• W4385409825 cites W2560264526 @default.
• W4385409825 cites W2595886211 @default.
• W4385409825 cites W2611067537 @default.
• W4385409825 cites W2766314050 @default.
• W4385409825 cites W2780354290 @default.
• W4385409825 cites W2799524357 @default.
• W4385409825 cites W2799794438 @default.
• W4385409825 cites W2890908390 @default.
• W4385409825 cites W2973305114 @default.
• W4385409825 cites W2977368063 @default.
• W4385409825 cites W2979705777 @default.
• W4385409825 cites W3017306313 @default.
• W4385409825 cites W3028635273 @default.
• W4385409825 cites W3028765608 @default.
• W4385409825 cites W3103611992 @default.
• W4385409825 cites W3106456053 @default.
• W4385409825 cites W3109378828 @default.
• W4385409825 cites W3129048863 @default.
• W4385409825 cites W3156458251 @default.
• W4385409825 cites W3158623004 @default.
• W4385409825 cites W3177828909 @default.
• W4385409825 cites W3183475563 @default.
• W4385409825 cites W3197256002 @default.
• W4385409825 cites W3211795435 @default.
• W4385409825 cites W4210702584 @default.
• W4385409825 cites W4213112325 @default.
• W4385409825 cites W4283123783 @default.
• W4385409825 cites W4308616064 @default.
• W4385409825 cites W4385409825 @default.
• W4385409825 doi "https://doi.org/10.1073/pnas.2218217120" @default.
• W4385409825 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37523524" @default.
• W4385409825 hasPublicationYear "2023" @default.
• W4385409825 type Work @default.
• W4385409825 citedByCount "2" @default.
• W4385409825 countsByYear W43854098252023 @default.
• W4385409825 crossrefType "journal-article" @default.
• W4385409825 hasAuthorship W4385409825A5028283040 @default.
• W4385409825 hasAuthorship W4385409825A5044273102 @default.
• W4385409825 hasAuthorship W4385409825A5044840019 @default.
• W4385409825 hasAuthorship W4385409825A5055873619 @default.
• W4385409825 hasAuthorship W4385409825A5072168949 @default.
• W4385409825 hasAuthorship W4385409825A5079783310 @default.
• W4385409825 hasBestOaLocation W43854098251 @default.

• next