Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385421115> ?p ?o ?g. }
- W4385421115 endingPage "4987" @default.
- W4385421115 startingPage "4987" @default.
- W4385421115 abstract "Immune checkpoint inhibitor (ICI) therapy has revolutionized renal cell carcinoma treatment. Patients previously thought to be palliative now occasionally achieve complete cures from ICI. However, since immunotherapies stimulate the immune system to induce anti-tumor immunity, they often lead to adverse autoimmunity. Furthermore, some patients receive no benefit from ICI, thereby unnecessarily risking adverse events. In many tumor types, PD-L1 expression levels, immune infiltration, and tumor mutation burden predict the response to ICI and help inform clinical decision making to better target ICI to patients most likely to experience benefits. Unfortunately, renal cell carcinoma is an outlier, as these biomarkers fail to discriminate between positive and negative responses to ICI therapy. Emerging biomarkers such as gene expression profiles and the loss of pro-angiogenic proteins VHL and PBRM-1 show promise for identifying renal cell carcinoma cases likely to respond to ICI. This review provides an overview of the mechanistic underpinnings of different biomarkers and describes the theoretical rationale for their use. We discuss the effectiveness of each biomarker in renal cell carcinoma and other cancer types, and we introduce novel biomarkers that have demonstrated some promise in clinical trials." @default.
- W4385421115 created "2023-08-01" @default.
- W4385421115 creator A5022646967 @default.
- W4385421115 creator A5024061152 @default.
- W4385421115 creator A5029868109 @default.
- W4385421115 creator A5052382886 @default.
- W4385421115 date "2023-07-28" @default.
- W4385421115 modified "2023-10-16" @default.
- W4385421115 title "Biomarkers for Immune Checkpoint Inhibitors in Renal Cell Carcinoma" @default.
- W4385421115 cites W1910012553 @default.
- W4385421115 cites W1940241680 @default.
- W4385421115 cites W1945781715 @default.
- W4385421115 cites W1966565248 @default.
- W4385421115 cites W1971047245 @default.
- W4385421115 cites W1980137951 @default.
- W4385421115 cites W1983517349 @default.
- W4385421115 cites W1992350807 @default.
- W4385421115 cites W1994375251 @default.
- W4385421115 cites W2004150448 @default.
- W4385421115 cites W2007088792 @default.
- W4385421115 cites W2008840129 @default.
- W4385421115 cites W2011458181 @default.
- W4385421115 cites W2014189487 @default.
- W4385421115 cites W2023952988 @default.
- W4385421115 cites W2028433016 @default.
- W4385421115 cites W2046507292 @default.
- W4385421115 cites W2049553585 @default.
- W4385421115 cites W2049964698 @default.
- W4385421115 cites W2099088585 @default.
- W4385421115 cites W2100669312 @default.
- W4385421115 cites W2104885590 @default.
- W4385421115 cites W2104966044 @default.
- W4385421115 cites W2115494288 @default.
- W4385421115 cites W2140069170 @default.
- W4385421115 cites W2140741923 @default.
- W4385421115 cites W2149456801 @default.
- W4385421115 cites W2156906256 @default.
- W4385421115 cites W2162424705 @default.
- W4385421115 cites W2169403180 @default.
- W4385421115 cites W2179389093 @default.
- W4385421115 cites W2222086386 @default.
- W4385421115 cites W2263759961 @default.
- W4385421115 cites W2298626553 @default.
- W4385421115 cites W2334694951 @default.
- W4385421115 cites W2335012284 @default.
- W4385421115 cites W2340636398 @default.
- W4385421115 cites W2340753924 @default.
- W4385421115 cites W2371138393 @default.
- W4385421115 cites W2403289604 @default.
- W4385421115 cites W2403400382 @default.
- W4385421115 cites W2425731878 @default.
- W4385421115 cites W2465309696 @default.
- W4385421115 cites W2522313999 @default.
- W4385421115 cites W2530419161 @default.
- W4385421115 cites W2559953355 @default.
- W4385421115 cites W2560367415 @default.
- W4385421115 cites W2581342866 @default.
- W4385421115 cites W2588457489 @default.
- W4385421115 cites W2589053981 @default.
- W4385421115 cites W2606495925 @default.
- W4385421115 cites W2614480329 @default.
- W4385421115 cites W2655262992 @default.
- W4385421115 cites W2664203916 @default.
- W4385421115 cites W2725858612 @default.
- W4385421115 cites W2737082469 @default.
- W4385421115 cites W2749499006 @default.
- W4385421115 cites W2751411673 @default.
- W4385421115 cites W2761586559 @default.
- W4385421115 cites W2779221466 @default.
- W4385421115 cites W2782183686 @default.
- W4385421115 cites W2783733493 @default.
- W4385421115 cites W2790574591 @default.
- W4385421115 cites W2792937256 @default.
- W4385421115 cites W2804073610 @default.
- W4385421115 cites W2804661897 @default.
- W4385421115 cites W2805302875 @default.
- W4385421115 cites W2807534769 @default.
- W4385421115 cites W2887577080 @default.
- W4385421115 cites W2899435407 @default.
- W4385421115 cites W2901850955 @default.
- W4385421115 cites W2909679049 @default.
- W4385421115 cites W2911812451 @default.
- W4385421115 cites W2913044136 @default.
- W4385421115 cites W2913745075 @default.
- W4385421115 cites W2916451481 @default.
- W4385421115 cites W2943887705 @default.
- W4385421115 cites W2954615294 @default.
- W4385421115 cites W2967350775 @default.
- W4385421115 cites W2972162958 @default.
- W4385421115 cites W2975736787 @default.
- W4385421115 cites W2979972034 @default.
- W4385421115 cites W2980823965 @default.
- W4385421115 cites W2980933209 @default.
- W4385421115 cites W2982130750 @default.
- W4385421115 cites W2987116731 @default.
- W4385421115 cites W2988644538 @default.
- W4385421115 cites W2995123342 @default.
- W4385421115 cites W2999417355 @default.