Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385421635> ?p ?o ?g. }
- W4385421635 endingPage "1933" @default.
- W4385421635 startingPage "1933" @default.
- W4385421635 abstract "The Candidate Phyla Radiation (CPR) was found to harbor a vast repertoire of genes encoding for enzymes with potential antibiotic resistance activity. Among these, as many as 3349 genes were predicted in silico to contain a metallo-beta-lactamase-like (MBL-like) fold. These proteins were subject to an in silico functional characterization by comparing their protein profiles (presence/absence of conserved protein domains) to other MBLs, including 24 already expressed in vitro, along with those of the beta-lactamase database (BLDB) (n = 761). The sequence similarity network (SSN) was then used to predict the functional clusters of CPR MBL-like sequences. Our findings showed that CPR MBL-like sequences were longer and more diverse than bacterial MBL sequences, with a high content of functional domains. Most CPR MBL-like sequences did not show any SSN connectivity with expressed MBLs, indicating the presence of many potential, yet unidentified, functions in CPR. In conclusion, CPR was shown to have many protein functions and a large sequence variability of MBL-like folds, exceeding all known MBLs. Further experimental and evolutionary studies of this superfamily of hydrolyzing enzymes are necessary to illustrate their functional annotation, origin, and expansion for adaptation or specialization within a given niche or compared to a specific substrate." @default.
- W4385421635 created "2023-08-01" @default.
- W4385421635 creator A5012670349 @default.
- W4385421635 creator A5015091524 @default.
- W4385421635 creator A5048908344 @default.
- W4385421635 creator A5058020631 @default.
- W4385421635 creator A5067647822 @default.
- W4385421635 creator A5077845477 @default.
- W4385421635 date "2023-07-28" @default.
- W4385421635 modified "2023-10-18" @default.
- W4385421635 title "Metallo-Beta-Lactamase-like Encoding Genes in Candidate Phyla Radiation: Widespread and Highly Divergent Proteins with Potential Multifunctionality" @default.
- W4385421635 cites W1511757521 @default.
- W4385421635 cites W1803102843 @default.
- W4385421635 cites W1861263514 @default.
- W4385421635 cites W1965606033 @default.
- W4385421635 cites W1970885167 @default.
- W4385421635 cites W1971072534 @default.
- W4385421635 cites W1972382894 @default.
- W4385421635 cites W1982554906 @default.
- W4385421635 cites W1983186463 @default.
- W4385421635 cites W1984253636 @default.
- W4385421635 cites W1986008479 @default.
- W4385421635 cites W1994144563 @default.
- W4385421635 cites W1995167648 @default.
- W4385421635 cites W1996351562 @default.
- W4385421635 cites W1998238795 @default.
- W4385421635 cites W1999106047 @default.
- W4385421635 cites W2024195254 @default.
- W4385421635 cites W2040374422 @default.
- W4385421635 cites W2044998678 @default.
- W4385421635 cites W2058638812 @default.
- W4385421635 cites W2060797027 @default.
- W4385421635 cites W2060894986 @default.
- W4385421635 cites W2070818602 @default.
- W4385421635 cites W2072854916 @default.
- W4385421635 cites W2073703928 @default.
- W4385421635 cites W2076505260 @default.
- W4385421635 cites W2077564233 @default.
- W4385421635 cites W2092193084 @default.
- W4385421635 cites W2103731920 @default.
- W4385421635 cites W2104785942 @default.
- W4385421635 cites W2106020100 @default.
- W4385421635 cites W2107251251 @default.
- W4385421635 cites W2113561798 @default.
- W4385421635 cites W2119127527 @default.
- W4385421635 cites W2123981614 @default.
- W4385421635 cites W2125609055 @default.
- W4385421635 cites W2132957182 @default.
- W4385421635 cites W2144494426 @default.
- W4385421635 cites W2153650805 @default.
- W4385421635 cites W2154108344 @default.
- W4385421635 cites W2155742215 @default.
- W4385421635 cites W2315521535 @default.
- W4385421635 cites W2343321668 @default.
- W4385421635 cites W2533015169 @default.
- W4385421635 cites W2539913165 @default.
- W4385421635 cites W2737879351 @default.
- W4385421635 cites W2751960558 @default.
- W4385421635 cites W2753961085 @default.
- W4385421635 cites W2765677637 @default.
- W4385421635 cites W2768035568 @default.
- W4385421635 cites W2768548400 @default.
- W4385421635 cites W2799649967 @default.
- W4385421635 cites W2892009916 @default.
- W4385421635 cites W2893848567 @default.
- W4385421635 cites W2925800094 @default.
- W4385421635 cites W2969753721 @default.
- W4385421635 cites W2972943898 @default.
- W4385421635 cites W3044187108 @default.
- W4385421635 cites W3092602006 @default.
- W4385421635 cites W3104587826 @default.
- W4385421635 cites W3112831494 @default.
- W4385421635 cites W3123494798 @default.
- W4385421635 cites W3165582481 @default.
- W4385421635 cites W3167324050 @default.
- W4385421635 cites W4210500099 @default.
- W4385421635 cites W4226113891 @default.
- W4385421635 cites W4226291543 @default.
- W4385421635 cites W4280507217 @default.
- W4385421635 cites W4281642528 @default.
- W4385421635 cites W4382751239 @default.
- W4385421635 doi "https://doi.org/10.3390/microorganisms11081933" @default.
- W4385421635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37630493" @default.
- W4385421635 hasPublicationYear "2023" @default.
- W4385421635 type Work @default.
- W4385421635 citedByCount "0" @default.
- W4385421635 crossrefType "journal-article" @default.
- W4385421635 hasAuthorship W4385421635A5012670349 @default.
- W4385421635 hasAuthorship W4385421635A5015091524 @default.
- W4385421635 hasAuthorship W4385421635A5048908344 @default.
- W4385421635 hasAuthorship W4385421635A5058020631 @default.
- W4385421635 hasAuthorship W4385421635A5067647822 @default.
- W4385421635 hasAuthorship W4385421635A5077845477 @default.
- W4385421635 hasBestOaLocation W43854216351 @default.
- W4385421635 hasConcept C104317684 @default.
- W4385421635 hasConcept C167625842 @default.
- W4385421635 hasConcept C2775905019 @default.
- W4385421635 hasConcept C45484198 @default.