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- W4385421815 abstract "The developmental origin of health and disease (DOHaD) hypothesis refers to the adverse effects of suboptimal developmental environments during embryonic and early fetal stages on the long-term health of offspring. Intrauterine metabolic perturbations can profoundly impact organogenesis in offspring, particularly affecting cardiac development and giving rise to potential structural and functional abnormalities. In this discussion, we contemplate the existing understanding regarding the impact of maternal metabolic disorders, such as obesity, diabetes, or undernutrition, on the developmental and functional aspects of the offspring’s heart. This influence has the potential to contribute to the susceptibility of offspring to cardiovascular health issues. Alteration in the nutritional milieu can influence mitochondrial function in the developing hearts of offspring, while also serving as signaling molecules that directly modulate gene expression. Moreover, metabolic disorders can exert influence on cardiac development-related genes epigenetically through DNA methylation, levels of histone modifications, microRNA expression, and other factors. However, the comprehensive understanding of the mechanistic underpinnings of these phenomena remains incomplete. Further investigations in this domain hold profound clinical significance, as they can contribute to the enhancement of public health and the prevention of cardiovascular diseases." @default.
- W4385421815 created "2023-08-01" @default.
- W4385421815 creator A5015747340 @default.
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- W4385421815 date "2023-07-30" @default.
- W4385421815 modified "2023-10-18" @default.
- W4385421815 title "Research Progress of Maternal Metabolism on Cardiac Development and Function in Offspring" @default.
- W4385421815 cites W1901811522 @default.
- W4385421815 cites W1941532063 @default.
- W4385421815 cites W1942622002 @default.
- W4385421815 cites W1968550558 @default.
- W4385421815 cites W1971226672 @default.
- W4385421815 cites W1973917991 @default.
- W4385421815 cites W1975162123 @default.
- W4385421815 cites W1986727625 @default.
- W4385421815 cites W2000643914 @default.
- W4385421815 cites W2002304855 @default.
- W4385421815 cites W2009396016 @default.
- W4385421815 cites W2011203565 @default.
- W4385421815 cites W2066310287 @default.
- W4385421815 cites W2075074527 @default.
- W4385421815 cites W2076598575 @default.
- W4385421815 cites W2085742428 @default.
- W4385421815 cites W2102194053 @default.
- W4385421815 cites W2105731956 @default.
- W4385421815 cites W2105946941 @default.
- W4385421815 cites W2114576253 @default.
- W4385421815 cites W2131165622 @default.
- W4385421815 cites W2133703816 @default.
- W4385421815 cites W2137542514 @default.
- W4385421815 cites W2139369236 @default.
- W4385421815 cites W2148462747 @default.
- W4385421815 cites W2149812883 @default.
- W4385421815 cites W2162468574 @default.
- W4385421815 cites W2164404896 @default.
- W4385421815 cites W2167982565 @default.
- W4385421815 cites W2184931495 @default.
- W4385421815 cites W2299303320 @default.
- W4385421815 cites W2319813837 @default.
- W4385421815 cites W2372435063 @default.
- W4385421815 cites W2402305434 @default.
- W4385421815 cites W2422156972 @default.
- W4385421815 cites W2502871139 @default.
- W4385421815 cites W2518696886 @default.
- W4385421815 cites W2530971149 @default.
- W4385421815 cites W2531320855 @default.
- W4385421815 cites W2556548281 @default.
- W4385421815 cites W2560198845 @default.
- W4385421815 cites W2580156750 @default.
- W4385421815 cites W2591679458 @default.
- W4385421815 cites W2593494122 @default.
- W4385421815 cites W2594733853 @default.
- W4385421815 cites W2607367045 @default.
- W4385421815 cites W2625586218 @default.
- W4385421815 cites W2719048931 @default.
- W4385421815 cites W2743638143 @default.
- W4385421815 cites W2750688577 @default.
- W4385421815 cites W2765100641 @default.
- W4385421815 cites W2768517083 @default.
- W4385421815 cites W2773897061 @default.
- W4385421815 cites W2784314232 @default.
- W4385421815 cites W2787931223 @default.
- W4385421815 cites W2790802131 @default.
- W4385421815 cites W2794584941 @default.
- W4385421815 cites W2795824202 @default.
- W4385421815 cites W2808247149 @default.
- W4385421815 cites W2809295497 @default.
- W4385421815 cites W2888423604 @default.
- W4385421815 cites W2888850090 @default.
- W4385421815 cites W2889074368 @default.
- W4385421815 cites W2894764101 @default.
- W4385421815 cites W2894798854 @default.
- W4385421815 cites W2909413406 @default.
- W4385421815 cites W2914578573 @default.
- W4385421815 cites W2918568019 @default.
- W4385421815 cites W2947355008 @default.
- W4385421815 cites W2949571715 @default.
- W4385421815 cites W2952057547 @default.
- W4385421815 cites W2952377980 @default.
- W4385421815 cites W2969945357 @default.
- W4385421815 cites W2992178815 @default.
- W4385421815 cites W2999426255 @default.
- W4385421815 cites W3002913709 @default.
- W4385421815 cites W3007595289 @default.
- W4385421815 cites W3044867874 @default.
- W4385421815 cites W3087180829 @default.
- W4385421815 cites W3087264118 @default.
- W4385421815 cites W3087955752 @default.
- W4385421815 cites W3088237632 @default.
- W4385421815 cites W3094337438 @default.
- W4385421815 cites W3097288581 @default.
- W4385421815 cites W3104054476 @default.
- W4385421815 cites W3108715114 @default.
- W4385421815 cites W3122499612 @default.