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• W4385426696 abstract "Abstract Background The methylation SEPT9 (mSEPT9) appeared to be effective for hepatocellular carcinoma (HCC) detection. However, its performance in high-risk population has not been validated. We designed a pilot study and aimed to investigate the performance of mSEPT9, AFP, PIVKA-II and their combination in hepatic cirrhosis (HC) population. Methods A training cohort was established including 103 HCC and 114 HC patients. 10 ml blood was collected from each patient with K 2 EDTA tubes, and 3–4 ml plasma was extracted for subsequent tests. The performance of mSEPT9, AFP, PIVKA-II and their combination was optimized by the training cohort. Test performance was prospectively validated with a validation cohort, including 51 HCC and 121 HC patients. Results At the optimal thresholds in the training cohort, the sensitivity, specificity and area under curve (AUC) was 72.82%, 89.47%, 0.84, and 48.57%, 89.92%, 0.79, and 63.64%, 95.95%, 0.79 for mSEPT9, AFP and PIVKA-II, respectively. The combined test significantly increased the sensitivity to 84.47% (P < 0.05) at the specificity of 86.84% with an AUC of 0.91. Stage-dependent performance was observed with all single markers and their combination in plasma marker levels, positive detection rate (PDR) and AUC. Moderate correlation was found between mSEPT9 and AFP plasma levels (r = 0.527, P < 0.0001). Good complementarity was found between any two of the three markers, providing optimal sensitivity in HCC detection when used in combination. Subsequent validation achieved a sensitivity, specificity and AUC of 65.31%, 92.86%, 0.80, and 44.24%, 89.26%, 0.75, and 62.22%, 95.27%, 0.78 for mSEPT9, AFP and PIVKA-II, respectively. The combined test yielded a significantly increased sensitivity of 84.00% (P < 0.05) at 85.57% specificity, with an AUC at 0.89. Conclusions The performance was optimal by the combination of mSEPT9, AFP, PIVKA-II compared with any single marker, and the combination may be effective for HCC opportunistic screening in HC population." @default.
• W4385426696 created "2023-08-01" @default.
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• W4385426696 date "2023-07-31" @default.
• W4385426696 modified "2023-10-16" @default.
• W4385426696 title "Methylated SEPT9 combined with AFP and PIVKA-II is effective for the detection of HCC in high-risk population" @default.
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• W4385426696 cites W1970920494 @default.
• W4385426696 cites W1978970861 @default.
• W4385426696 cites W1981365088 @default.
• W4385426696 cites W2000881039 @default.
• W4385426696 cites W2004554617 @default.
• W4385426696 cites W2027433423 @default.
• W4385426696 cites W2045174122 @default.
• W4385426696 cites W2069129640 @default.
• W4385426696 cites W2071476028 @default.
• W4385426696 cites W2084324543 @default.
• W4385426696 cites W2101270576 @default.
• W4385426696 cites W2106285087 @default.
• W4385426696 cites W2111456931 @default.
• W4385426696 cites W2153283984 @default.
• W4385426696 cites W2159343208 @default.
• W4385426696 cites W2161315819 @default.
• W4385426696 cites W2171237493 @default.
• W4385426696 cites W2342656665 @default.
• W4385426696 cites W2569705407 @default.
• W4385426696 cites W2621272124 @default.
• W4385426696 cites W2764195238 @default.
• W4385426696 cites W2783674487 @default.
• W4385426696 cites W2786099441 @default.
• W4385426696 cites W2790720112 @default.
• W4385426696 cites W2794450296 @default.
• W4385426696 cites W2794803931 @default.
• W4385426696 cites W2796061519 @default.
• W4385426696 cites W2796067155 @default.
• W4385426696 cites W2797197823 @default.
• W4385426696 cites W2800065929 @default.
• W4385426696 cites W2888026526 @default.
• W4385426696 cites W2889162157 @default.
• W4385426696 cites W2890926168 @default.
• W4385426696 cites W2895565245 @default.
• W4385426696 cites W2922467660 @default.
• W4385426696 cites W2935719033 @default.
• W4385426696 cites W2948870906 @default.
• W4385426696 cites W2964930572 @default.
• W4385426696 cites W2977680082 @default.
• W4385426696 cites W2983020673 @default.
• W4385426696 cites W2997319650 @default.
• W4385426696 cites W2997822868 @default.
• W4385426696 cites W3009995857 @default.
• W4385426696 cites W3011410748 @default.
• W4385426696 cites W3044553904 @default.
• W4385426696 cites W3081978148 @default.
• W4385426696 cites W3087371465 @default.
• W4385426696 cites W3091233587 @default.
• W4385426696 cites W3094239942 @default.
• W4385426696 cites W3096411302 @default.
• W4385426696 cites W3102998479 @default.
• W4385426696 cites W3128646645 @default.
• W4385426696 cites W3130961242 @default.
• W4385426696 cites W3134066937 @default.
• W4385426696 cites W3136174586 @default.
• W4385426696 cites W3136203628 @default.
• W4385426696 cites W3155134882 @default.
• W4385426696 cites W3165133969 @default.
• W4385426696 cites W3169699960 @default.
• W4385426696 cites W3204744768 @default.
• W4385426696 cites W4210254201 @default.
• W4385426696 cites W4210499162 @default.
• W4385426696 cites W4210598011 @default.
• W4385426696 cites W4225090144 @default.
• W4385426696 cites W4284885824 @default.
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• W4385426696 cites W4309822144 @default.
• W4385426696 cites W4311582043 @default.
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• W4385426696 cites W4313582628 @default.
• W4385426696 cites W4313857721 @default.
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• W4385426696 doi "https://doi.org/10.1186/s12876-023-02900-6" @default.
• W4385426696 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37525116" @default.
• W4385426696 hasPublicationYear "2023" @default.
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