Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385428596> ?p ?o ?g. }
- W4385428596 endingPage "12265" @default.
- W4385428596 startingPage "12265" @default.
- W4385428596 abstract "Several studies have suggested that a phenolic-rich diet may be protective against colon cancer. Most phenolic compounds are not absorbed in the small intestine and reach the colon where they are metabolized by gut microbiota in simple phenolic acids. In this study, the anti-proliferative activity of quercetins, chlorogenic acids, their colon metabolites and mixtures of parent compounds/metabolites was assessed by using two colon cancer cell lines (Caco-2 and SW480) at physiologically relevant concentrations. Chlorogenic acids, quercetin and the metabolite 3-(3′,4′-dihydroxyphenyl)acetic acid exerted remarkable anti-proliferative activity against Caco-2, whereas quercetin derivatives and metabolites were the most active against SW480. Tested compounds arrested the cell cycle at the S phase in both the cell lines. The mixtures of parent compounds/metabolites, which mimic the colon human metabotypes that slowly or rapidly metabolize the parent compounds, similarly inhibited cell growth. SW480 cells metabolized parent phenolic compounds more rapidly and extensively than Caco-2, whereas colon metabolites were more stable. These results suggest that dietary phenolic compounds exert an anti-proliferative effect against human colon cancer cells that can be further sustained by the colon metabolites. Therefore, gut microbiota metabolism of phenolic compounds may be of paramount importance in explaining the protective effect of phenolic-rich foods against colon cancer." @default.
- W4385428596 created "2023-08-01" @default.
- W4385428596 creator A5018543602 @default.
- W4385428596 creator A5045844470 @default.
- W4385428596 creator A5085873384 @default.
- W4385428596 date "2023-07-31" @default.
- W4385428596 modified "2023-09-26" @default.
- W4385428596 title "Quercetins, Chlorogenic Acids and Their Colon Metabolites Inhibit Colon Cancer Cell Proliferation at Physiologically Relevant Concentrations" @default.
- W4385428596 cites W1530048637 @default.
- W4385428596 cites W1971154691 @default.
- W4385428596 cites W1979129905 @default.
- W4385428596 cites W1980883307 @default.
- W4385428596 cites W1985716651 @default.
- W4385428596 cites W1998172325 @default.
- W4385428596 cites W2004592921 @default.
- W4385428596 cites W2011336591 @default.
- W4385428596 cites W2016211892 @default.
- W4385428596 cites W2018438226 @default.
- W4385428596 cites W2038246208 @default.
- W4385428596 cites W2045422802 @default.
- W4385428596 cites W2055869166 @default.
- W4385428596 cites W2070882338 @default.
- W4385428596 cites W2084662944 @default.
- W4385428596 cites W2098555011 @default.
- W4385428596 cites W2127507974 @default.
- W4385428596 cites W2128493043 @default.
- W4385428596 cites W2136134329 @default.
- W4385428596 cites W2142596415 @default.
- W4385428596 cites W2201258486 @default.
- W4385428596 cites W2522933469 @default.
- W4385428596 cites W2591801061 @default.
- W4385428596 cites W2601367389 @default.
- W4385428596 cites W2658069214 @default.
- W4385428596 cites W2731343080 @default.
- W4385428596 cites W2740663395 @default.
- W4385428596 cites W2768681000 @default.
- W4385428596 cites W2773268832 @default.
- W4385428596 cites W2789926774 @default.
- W4385428596 cites W2794417158 @default.
- W4385428596 cites W2799518051 @default.
- W4385428596 cites W2804450233 @default.
- W4385428596 cites W2884687648 @default.
- W4385428596 cites W2895356216 @default.
- W4385428596 cites W2905370817 @default.
- W4385428596 cites W2910396248 @default.
- W4385428596 cites W2924920952 @default.
- W4385428596 cites W2946830692 @default.
- W4385428596 cites W2971289492 @default.
- W4385428596 cites W2991184544 @default.
- W4385428596 cites W3010924948 @default.
- W4385428596 cites W3023680407 @default.
- W4385428596 cites W3043105137 @default.
- W4385428596 cites W3047947891 @default.
- W4385428596 cites W3049372395 @default.
- W4385428596 cites W3089648184 @default.
- W4385428596 cites W3096023666 @default.
- W4385428596 cites W3118563245 @default.
- W4385428596 cites W3128646645 @default.
- W4385428596 cites W3128872334 @default.
- W4385428596 cites W3149717808 @default.
- W4385428596 cites W3155387234 @default.
- W4385428596 cites W3159324659 @default.
- W4385428596 cites W3161885304 @default.
- W4385428596 cites W3186716007 @default.
- W4385428596 cites W3194722394 @default.
- W4385428596 cites W3194770167 @default.
- W4385428596 cites W4210855091 @default.
- W4385428596 cites W4220962548 @default.
- W4385428596 cites W4223924683 @default.
- W4385428596 cites W4285735201 @default.
- W4385428596 cites W4286214198 @default.
- W4385428596 cites W4289745369 @default.
- W4385428596 cites W4293493612 @default.
- W4385428596 cites W4360595746 @default.
- W4385428596 doi "https://doi.org/10.3390/ijms241512265" @default.
- W4385428596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37569640" @default.
- W4385428596 hasPublicationYear "2023" @default.
- W4385428596 type Work @default.
- W4385428596 citedByCount "0" @default.
- W4385428596 crossrefType "journal-article" @default.
- W4385428596 hasAuthorship W4385428596A5018543602 @default.
- W4385428596 hasAuthorship W4385428596A5045844470 @default.
- W4385428596 hasAuthorship W4385428596A5085873384 @default.
- W4385428596 hasBestOaLocation W43854285961 @default.
- W4385428596 hasConcept C121608353 @default.
- W4385428596 hasConcept C1491633281 @default.
- W4385428596 hasConcept C185592680 @default.
- W4385428596 hasConcept C193176779 @default.
- W4385428596 hasConcept C2777477808 @default.
- W4385428596 hasConcept C2778004101 @default.
- W4385428596 hasConcept C2780117898 @default.
- W4385428596 hasConcept C2781263971 @default.
- W4385428596 hasConcept C31903555 @default.
- W4385428596 hasConcept C526805850 @default.
- W4385428596 hasConcept C54355233 @default.
- W4385428596 hasConcept C55493867 @default.
- W4385428596 hasConcept C62112901 @default.
- W4385428596 hasConcept C62231903 @default.