FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385428992> ?p ?o ?g. }

• W4385428992 endingPage "1533" @default.
• W4385428992 startingPage "1533" @default.
• W4385428992 abstract "Bradykinin is a small active peptide and is considered an inflammatory mediator in several pathological conditions. Bradykinin exerts its effects by coupling to its receptors, including bradykinin B1 (B1R) and bradykinin B2. B1R has been implicated in the development of various cancers. Our previous study reported that B1R promoted glioblastoma (GBM) development by supporting the migration and invasion of GBM cells. However, the mechanisms underlying the effects of B1R on tumor-associated macrophages (TAMs) and GBM progression remain unknown. Accordingly, to explore the regulatory effects of B1R overexpression (OE) in GBM on tumor-associated immune cells and tumor progression, we constructed a B1R wild-type plasmid and developed a B1R OE model. The results reveal that B1R OE in GBM promoted the expression of ICAM-1 and VCAM-1—cell adhesion molecules—in GBM. Moreover, B1R OE enhanced GBM cell migration ability and monocyte attachment. B1R also regulated the production of the protumorigenic cytokines and chemokines IL-6, IL-8, CXCL11, and CCL5 in GBM, which contributed to tumor progression. We additionally noted that B1R OE in GBM increased the expression of CD68 in TAMs. Furthermore, B1R OE reduced the level of reactive oxygen species in GBM cells by upregulating heme oxygenase-1, an endogenous antioxidant protein, thereby protecting GBM cells from oxidative stress. Notably, B1R OE upregulated the expression of programmed death-ligand 1 in both GBM cells and macrophages, thus providing resistance against T-cell response. B1R OE in GBM also promoted tumor growth and reduced survival rates in an intracranial xenograft mouse model. These results indicate that B1R expression in GBM promotes TAM activity and modulates GBM progression. Therefore, B1R could be an effective target for therapeutic methods in GBM." @default.
• W4385428992 created "2023-08-01" @default.
• W4385428992 creator A5006721065 @default.
• W4385428992 creator A5007501604 @default.
• W4385428992 creator A5028008344 @default.
• W4385428992 creator A5053811170 @default.
• W4385428992 creator A5062167536 @default.
• W4385428992 creator A5073558272 @default.
• W4385428992 creator A5075713374 @default.
• W4385428992 creator A5085718879 @default.
• W4385428992 creator A5088950177 @default.
• W4385428992 date "2023-07-31" @default.
• W4385428992 modified "2023-10-16" @default.
• W4385428992 title "Bradykinin B1 Receptor Affects Tumor-Associated Macrophage Activity and Glioblastoma Progression" @default.
• W4385428992 cites W1543746024 @default.
• W4385428992 cites W1549926314 @default.
• W4385428992 cites W1560983797 @default.
• W4385428992 cites W1815157104 @default.
• W4385428992 cites W1963904011 @default.
• W4385428992 cites W1966687109 @default.
• W4385428992 cites W1966859474 @default.
• W4385428992 cites W1970846476 @default.
• W4385428992 cites W1973736663 @default.
• W4385428992 cites W1975062036 @default.
• W4385428992 cites W1986545748 @default.
• W4385428992 cites W1991063693 @default.
• W4385428992 cites W1991129425 @default.
• W4385428992 cites W1996436013 @default.
• W4385428992 cites W1998098900 @default.
• W4385428992 cites W1998105539 @default.
• W4385428992 cites W1998392042 @default.
• W4385428992 cites W2000975493 @default.
• W4385428992 cites W2001372725 @default.
• W4385428992 cites W2001717792 @default.
• W4385428992 cites W2006908114 @default.
• W4385428992 cites W2007087804 @default.
• W4385428992 cites W2018330241 @default.
• W4385428992 cites W2026972134 @default.
• W4385428992 cites W2030533491 @default.
• W4385428992 cites W2031880075 @default.
• W4385428992 cites W2037262701 @default.
• W4385428992 cites W2061209694 @default.
• W4385428992 cites W2061587443 @default.
• W4385428992 cites W2062643827 @default.
• W4385428992 cites W2063532871 @default.
• W4385428992 cites W2066411725 @default.
• W4385428992 cites W2066671159 @default.
• W4385428992 cites W2066710052 @default.
• W4385428992 cites W2084170466 @default.
• W4385428992 cites W2085436867 @default.
• W4385428992 cites W2090131666 @default.
• W4385428992 cites W2090263203 @default.
• W4385428992 cites W2094610765 @default.
• W4385428992 cites W2095738477 @default.
• W4385428992 cites W2096709242 @default.
• W4385428992 cites W2108417645 @default.
• W4385428992 cites W2112936527 @default.
• W4385428992 cites W2116371946 @default.
• W4385428992 cites W2120364485 @default.
• W4385428992 cites W2122294504 @default.
• W4385428992 cites W2125493895 @default.
• W4385428992 cites W2131222777 @default.
• W4385428992 cites W2142583019 @default.
• W4385428992 cites W2145739766 @default.
• W4385428992 cites W2149387197 @default.
• W4385428992 cites W2155464214 @default.
• W4385428992 cites W2159803625 @default.
• W4385428992 cites W2162853795 @default.
• W4385428992 cites W2164675211 @default.
• W4385428992 cites W2164758926 @default.
• W4385428992 cites W2166191769 @default.
• W4385428992 cites W2201767353 @default.
• W4385428992 cites W2233773910 @default.
• W4385428992 cites W2323518069 @default.
• W4385428992 cites W2428936938 @default.
• W4385428992 cites W2461570210 @default.
• W4385428992 cites W2520777724 @default.
• W4385428992 cites W2560367415 @default.
• W4385428992 cites W2584371626 @default.
• W4385428992 cites W2585236480 @default.
• W4385428992 cites W2615165013 @default.
• W4385428992 cites W2653322994 @default.
• W4385428992 cites W2742462785 @default.
• W4385428992 cites W2782615284 @default.
• W4385428992 cites W2782999996 @default.
• W4385428992 cites W2794944537 @default.
• W4385428992 cites W2802700419 @default.
• W4385428992 cites W2882007132 @default.
• W4385428992 cites W2890371056 @default.
• W4385428992 cites W2895907402 @default.
• W4385428992 cites W2896788268 @default.
• W4385428992 cites W2911604706 @default.
• W4385428992 cites W2912890763 @default.
• W4385428992 cites W2943191265 @default.
• W4385428992 cites W2952066700 @default.
• W4385428992 cites W2970047229 @default.
• W4385428992 cites W2985055874 @default.
• W4385428992 cites W2990257238 @default.

• next