Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385429464> ?p ?o ?g. }
- W4385429464 abstract "Abstract Background Previous studies have demonstrated that electrical stimulation of the cerebellar fastigial nucleus (FNS) can considerably decrease infarction volume and improve neurofunction restoration following cerebral ischemia. Nevertheless, the molecular mechanism of the neuroprotective effect of FNS is still vague. Methods In this study, we developed a rat model of ischemia/reperfusion that included 1 h FNS followed by reperfusion for 3, 6, 12, 24, and 72 h. The expression profile of molecular alterations in brain tissues was obtained by transcriptome sequencing at five different time points. The function and pathway of miRNA expression pattern and core genes were annotated by Allen Brain Atlas, STRING database and Cytoscape software, so as to explore the mechanism of FNS-mediated neuroprotection. Results The results indicated that FNS is associated with the neurotransmitter cycle pathway. FNS may regulate the release of monoamine neurotransmitters in synaptic vesicles by targeting the corresponding miRNAs through core Dlg4 gene, stimulate the Alternative polyadenylation (APA) incident’s anti -apoptosis effect on the brain, and stimulate the interaction activation of neurons in cerebellum, cortex/thalamus and other brain regions, regulate neurovascular coupling, and reduce cerebral damage. Conclusion FNS may activate neuronal and neurovascular coupling by regulating the release of neurotransmitters in synaptic vesicles through the methylation of core Dlg4 gene and the corresponding transcription factors and protein kinases, inducing the anti-apoptotic mechanism of APA events. The findings from our investigation offer a new perspective on the way brain tissue responds to FNS-driven neuroprotection." @default.
- W4385429464 created "2023-08-01" @default.
- W4385429464 creator A5008960269 @default.
- W4385429464 creator A5020341872 @default.
- W4385429464 creator A5020907276 @default.
- W4385429464 creator A5064454449 @default.
- W4385429464 creator A5067536392 @default.
- W4385429464 creator A5071798264 @default.
- W4385429464 creator A5080935093 @default.
- W4385429464 date "2023-07-31" @default.
- W4385429464 modified "2023-10-16" @default.
- W4385429464 title "Transcriptome analysis reveals the neuroprotective effect of Dlg4 against fastigial nucleus stimulation-induced ischemia/reperfusion injury in rats" @default.
- W4385429464 cites W1487695731 @default.
- W4385429464 cites W1740153932 @default.
- W4385429464 cites W1858579514 @default.
- W4385429464 cites W1964973404 @default.
- W4385429464 cites W1975389666 @default.
- W4385429464 cites W1975572742 @default.
- W4385429464 cites W1985267020 @default.
- W4385429464 cites W2013380034 @default.
- W4385429464 cites W2014564827 @default.
- W4385429464 cites W2014907593 @default.
- W4385429464 cites W2040341057 @default.
- W4385429464 cites W2053768195 @default.
- W4385429464 cites W2056385243 @default.
- W4385429464 cites W2062124861 @default.
- W4385429464 cites W2068033158 @default.
- W4385429464 cites W2074532634 @default.
- W4385429464 cites W2082377694 @default.
- W4385429464 cites W2083004303 @default.
- W4385429464 cites W2083875726 @default.
- W4385429464 cites W2087391811 @default.
- W4385429464 cites W2091536190 @default.
- W4385429464 cites W2103912979 @default.
- W4385429464 cites W2115115731 @default.
- W4385429464 cites W2123491442 @default.
- W4385429464 cites W2127681799 @default.
- W4385429464 cites W2128077939 @default.
- W4385429464 cites W2152258890 @default.
- W4385429464 cites W2171398108 @default.
- W4385429464 cites W2330303926 @default.
- W4385429464 cites W2340588071 @default.
- W4385429464 cites W2351673993 @default.
- W4385429464 cites W2462053388 @default.
- W4385429464 cites W2488953036 @default.
- W4385429464 cites W2750696266 @default.
- W4385429464 cites W2750747499 @default.
- W4385429464 cites W2770631390 @default.
- W4385429464 cites W2789305195 @default.
- W4385429464 cites W2791760233 @default.
- W4385429464 cites W2804408552 @default.
- W4385429464 cites W2897825874 @default.
- W4385429464 cites W2900569176 @default.
- W4385429464 cites W2913887378 @default.
- W4385429464 cites W2921542885 @default.
- W4385429464 cites W2921635835 @default.
- W4385429464 cites W2943225858 @default.
- W4385429464 cites W2946173685 @default.
- W4385429464 cites W2946296908 @default.
- W4385429464 cites W2947376247 @default.
- W4385429464 cites W2952754357 @default.
- W4385429464 cites W2976340066 @default.
- W4385429464 cites W2977063141 @default.
- W4385429464 cites W3007775395 @default.
- W4385429464 cites W3040774434 @default.
- W4385429464 cites W3092181383 @default.
- W4385429464 cites W3125885705 @default.
- W4385429464 cites W3143855125 @default.
- W4385429464 cites W3157343413 @default.
- W4385429464 cites W3184098745 @default.
- W4385429464 cites W3201686167 @default.
- W4385429464 cites W3212366636 @default.
- W4385429464 cites W3213051522 @default.
- W4385429464 cites W4220866967 @default.
- W4385429464 cites W4223642848 @default.
- W4385429464 cites W4224036376 @default.
- W4385429464 cites W4224288042 @default.
- W4385429464 cites W4226516293 @default.
- W4385429464 cites W4229332930 @default.
- W4385429464 cites W4229334882 @default.
- W4385429464 cites W4281390890 @default.
- W4385429464 cites W4281873243 @default.
- W4385429464 cites W4286751442 @default.
- W4385429464 cites W4292478704 @default.
- W4385429464 cites W4296106920 @default.
- W4385429464 doi "https://doi.org/10.1186/s12868-023-00811-6" @default.
- W4385429464 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37525090" @default.
- W4385429464 hasPublicationYear "2023" @default.
- W4385429464 type Work @default.
- W4385429464 citedByCount "0" @default.
- W4385429464 crossrefType "journal-article" @default.
- W4385429464 hasAuthorship W4385429464A5008960269 @default.
- W4385429464 hasAuthorship W4385429464A5020341872 @default.
- W4385429464 hasAuthorship W4385429464A5020907276 @default.
- W4385429464 hasAuthorship W4385429464A5064454449 @default.
- W4385429464 hasAuthorship W4385429464A5067536392 @default.
- W4385429464 hasAuthorship W4385429464A5071798264 @default.
- W4385429464 hasAuthorship W4385429464A5080935093 @default.
- W4385429464 hasBestOaLocation W43854294641 @default.
- W4385429464 hasConcept C104317684 @default.