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- W4385430320 abstract "Background: Dihydrofolate reductase (DHFR) is one of the indispensable targets and has important role in the survival of microorganisms. In traditional medicine, A. majus L. which is native to Egypt is an important plant due to its diverse pharmacology. It has been extensively studied to identify its phytoconstituents, biological activity, pharmacokinetic, and toxicity prole. Studies focusing on evaluation of A. majus against cancer, skin diseases, diuretic, etc. have been reported. In the present study we aimed to perform molecular docking studies along Methods: with ADME assessment for some of the important phytoconstituents of A. majus as antimicrobial agents. Signicant binding Results: interactions were reported. The study results will be helpful to understand the pharmacodynamic Conclusion: prole and establish its mechanism of action as potential inhibitors of DHFR." @default.
- W4385430320 created "2023-08-01" @default.
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- W4385430320 date "2023-07-15" @default.
- W4385430320 modified "2023-09-26" @default.
- W4385430320 title "INHIBITORS OF DIHYDROFOLATE REDUCTASE: MOLECULAR DOCKING AND ADME STUDIES" @default.
- W4385430320 doi "https://doi.org/10.36106/gjra/3408524" @default.
- W4385430320 hasPublicationYear "2023" @default.
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