Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385431368> ?p ?o ?g. }
- W4385431368 abstract "Stroke is one of the devastating clinical conditions that causes death and permanent disability. Its occurrence causes the reduction of oxygen and glucose supply, resulting in events such as inflammatory response, oxidative stress, and apoptosis in the brain. Microglia are brain-resident immune cells in the central nervous system (CNS) that exert diverse roles and respond to pathological process after an ischemic insult. The discovery of fibroblast growth factors (FGFs) in mammals, resulted to the findings that they can treat experimental models of stroke in animals effectively. FGFs function as homeostatic factors that control cells and hormones involved in metabolism, and they also regulate the secretion of proinflammatory (M1) and anti-inflammatory (M2) cytokines after stroke. In this review, we outline current evidence of microglia activation in experimental models of stroke focusing on its ability to exacerbate damage or repair tissue. Also, our review sheds light on the pharmacological actions of FGFs on multiple targets to regulate microglial modulation and highlighted their theoretical molecular mechanisms to provide possible therapeutic targets, as well as their limitations for the treatment of stroke. Not applicable" @default.
- W4385431368 created "2023-08-01" @default.
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- W4385431368 creator A5079715858 @default.
- W4385431368 date "2023-07-01" @default.
- W4385431368 modified "2023-09-26" @default.
- W4385431368 title "The role of microglial activation on ischemic stroke: Modulation by fibroblast growth factors" @default.
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