Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385441633> ?p ?o ?g. }
- W4385441633 endingPage "564" @default.
- W4385441633 startingPage "548" @default.
- W4385441633 abstract "A large body of evidence has demonstrated that exposure to childhood maltreatment at any stage of development can have long-lasting consequences. It is associated with a marked increase in risk for psychiatric and medical disorders. This review summarizes the literature investigating the effects of childhood maltreatment on disease vulnerability for mood disorders, specifically summarizing cross-sectional and more recent longitudinal studies demonstrating that childhood maltreatment is more prevalent and is associated with increased risk for first mood episode, episode recurrence, greater comorbidities, and increased risk for suicidal ideation and attempts in individuals with mood disorders. It summarizes the persistent alterations associated with childhood maltreatment, including alterations in the hypothalamic-pituitary-adrenal axis and inflammatory cytokines, which may contribute to disease vulnerability and a more pernicious disease course. The authors discuss several candidate genes and environmental factors (for example, substance use) that may alter disease vulnerability and illness course and neurobiological associations that may mediate these relationships following childhood maltreatment. Studies provide insight into modifiable mechanisms and provide direction to improve both treatment and prevention strategies." @default.
- W4385441633 created "2023-08-02" @default.
- W4385441633 creator A5037210460 @default.
- W4385441633 creator A5053954326 @default.
- W4385441633 date "2023-08-01" @default.
- W4385441633 modified "2023-09-27" @default.
- W4385441633 title "The Devastating Clinical Consequences of Child Abuse and Neglect: Increased Disease Vulnerability and Poor Treatment Response in Mood Disorders" @default.
- W4385441633 cites W1192524466 @default.
- W4385441633 cites W1520184724 @default.
- W4385441633 cites W1532290105 @default.
- W4385441633 cites W1545854379 @default.
- W4385441633 cites W1584418265 @default.
- W4385441633 cites W1590393443 @default.
- W4385441633 cites W1709742262 @default.
- W4385441633 cites W1717791288 @default.
- W4385441633 cites W1722369907 @default.
- W4385441633 cites W1732771611 @default.
- W4385441633 cites W1812416290 @default.
- W4385441633 cites W184579564 @default.
- W4385441633 cites W1860898731 @default.
- W4385441633 cites W1889921912 @default.
- W4385441633 cites W1943473395 @default.
- W4385441633 cites W1963793672 @default.
- W4385441633 cites W1964190827 @default.
- W4385441633 cites W1965636455 @default.
- W4385441633 cites W1968324782 @default.
- W4385441633 cites W1968569062 @default.
- W4385441633 cites W1973590155 @default.
- W4385441633 cites W1976711431 @default.
- W4385441633 cites W1977244886 @default.
- W4385441633 cites W1977419693 @default.
- W4385441633 cites W1982540819 @default.
- W4385441633 cites W1983227886 @default.
- W4385441633 cites W1983954953 @default.
- W4385441633 cites W1985129141 @default.
- W4385441633 cites W1985151675 @default.
- W4385441633 cites W1988595298 @default.
- W4385441633 cites W1989219942 @default.
- W4385441633 cites W1990849974 @default.
- W4385441633 cites W1994205479 @default.
- W4385441633 cites W1996026649 @default.
- W4385441633 cites W1997291002 @default.
- W4385441633 cites W2000289873 @default.
- W4385441633 cites W2001187532 @default.
- W4385441633 cites W2002675469 @default.
- W4385441633 cites W2005806468 @default.
- W4385441633 cites W2008113854 @default.
- W4385441633 cites W2010355855 @default.
- W4385441633 cites W2010523062 @default.
- W4385441633 cites W2011081879 @default.
- W4385441633 cites W2015231166 @default.
- W4385441633 cites W2016027357 @default.
- W4385441633 cites W2018407668 @default.
- W4385441633 cites W2018570780 @default.
- W4385441633 cites W2019876832 @default.
- W4385441633 cites W2020386120 @default.
- W4385441633 cites W2024031806 @default.
- W4385441633 cites W2026119228 @default.
- W4385441633 cites W2030971545 @default.
- W4385441633 cites W2032125557 @default.
- W4385441633 cites W2036194871 @default.
- W4385441633 cites W2038184188 @default.
- W4385441633 cites W2038714501 @default.
- W4385441633 cites W2040546819 @default.
- W4385441633 cites W2043313558 @default.
- W4385441633 cites W2046962754 @default.
- W4385441633 cites W2049086550 @default.
- W4385441633 cites W2049406343 @default.
- W4385441633 cites W2049491698 @default.
- W4385441633 cites W2050560433 @default.
- W4385441633 cites W2051922817 @default.
- W4385441633 cites W2052406842 @default.
- W4385441633 cites W2054132496 @default.
- W4385441633 cites W2054158871 @default.
- W4385441633 cites W2059962099 @default.
- W4385441633 cites W2061376086 @default.
- W4385441633 cites W2062989629 @default.
- W4385441633 cites W2063358832 @default.
- W4385441633 cites W2065623726 @default.
- W4385441633 cites W2067423618 @default.
- W4385441633 cites W2071747875 @default.
- W4385441633 cites W2073802984 @default.
- W4385441633 cites W2073997424 @default.
- W4385441633 cites W2074261744 @default.
- W4385441633 cites W2075720009 @default.
- W4385441633 cites W2095905365 @default.
- W4385441633 cites W2096671017 @default.
- W4385441633 cites W2100880539 @default.
- W4385441633 cites W2102666597 @default.
- W4385441633 cites W2104386846 @default.
- W4385441633 cites W2106658365 @default.
- W4385441633 cites W2106872732 @default.
- W4385441633 cites W2107871123 @default.
- W4385441633 cites W2110277535 @default.
- W4385441633 cites W2112692374 @default.
- W4385441633 cites W2114879270 @default.
- W4385441633 cites W2117055846 @default.
- W4385441633 cites W2117696268 @default.