FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385441796> ?p ?o ?g. }

• W4385441796 abstract "MicroRNAs (miRNAs) are small noncoding RNAs that control essential cellular processes. For several decades, the molecular mechanisms underlying the functions and biogenesis of miRNAs have been clarified, whereas the molecular dynamics of miRNAs are poorly understood. We recently found that muscle‐enriched miRNAs were reduced by only 20 ~ 50% in the skeletal muscles even 4 weeks after the suppression of miRNA processing through an inducible depletion of Dicer1 gene. These data suggest that miRNAs are stably expressed in skeletal muscle. In this study, we investigated the half‐lives of those miRNAs in adult skeletal muscle with an in vivo metabolic labeling strategy and a genetic mouse model. In contrast to the hypothesis, in vivo metabolic labeling revealed that the half‐lives of skeletal‐muscle‐enriched miRNAs were approximately 11–20 h. Furthermore, the levels of mature miR‐23a decreased rapidly in the skeletal muscle of mice lacking miR‐23 clusters in a tamoxifen‐inducible manner. These data suggest that skeletal‐muscle‐enriched miRNAs are not highly stable in vivo . We also observed that the transfer of miR‐150 into Dicer1 ‐deficient muscle increased the miR‐150 level to the same as that in control muscle. Taken together, our data demonstrate that miRNAs are degraded within a few days in adult skeletal muscle and that a Dicer‐independent biogenetic pathway may produce mature miRNAs." @default.
• W4385441796 created "2023-08-02" @default.
• W4385441796 creator A5012681781 @default.
• W4385441796 creator A5017525793 @default.
• W4385441796 creator A5023688006 @default.
• W4385441796 creator A5036672262 @default.
• W4385441796 date "2023-08-11" @default.
• W4385441796 modified "2023-10-18" @default.
• W4385441796 title "Skeletal muscle‐enriched <scp>miRNAs</scp> are highly unstable <i>in vivo</i> and may be regulated in a Dicer‐independent manner" @default.
• W4385441796 cites W144423133 @default.
• W4385441796 cites W1542414309 @default.
• W4385441796 cites W1965306643 @default.
• W4385441796 cites W1968525732 @default.
• W4385441796 cites W1977064582 @default.
• W4385441796 cites W1986903527 @default.
• W4385441796 cites W1989015932 @default.
• W4385441796 cites W1989917351 @default.
• W4385441796 cites W1990612961 @default.
• W4385441796 cites W1992941735 @default.
• W4385441796 cites W2000797813 @default.
• W4385441796 cites W2001889965 @default.
• W4385441796 cites W2006247279 @default.
• W4385441796 cites W2026472364 @default.
• W4385441796 cites W2042742511 @default.
• W4385441796 cites W2049836150 @default.
• W4385441796 cites W2060515857 @default.
• W4385441796 cites W2070345867 @default.
• W4385441796 cites W2089055162 @default.
• W4385441796 cites W2099855036 @default.
• W4385441796 cites W2118105142 @default.
• W4385441796 cites W2131293603 @default.
• W4385441796 cites W2131421168 @default.
• W4385441796 cites W2141157874 @default.
• W4385441796 cites W2153749888 @default.
• W4385441796 cites W2157741650 @default.
• W4385441796 cites W2160001954 @default.
• W4385441796 cites W2162423616 @default.
• W4385441796 cites W2163868691 @default.
• W4385441796 cites W2164079778 @default.
• W4385441796 cites W2168723894 @default.
• W4385441796 cites W2273997940 @default.
• W4385441796 cites W2299595562 @default.
• W4385441796 cites W2331669276 @default.
• W4385441796 cites W2808211577 @default.
• W4385441796 cites W2863481345 @default.
• W4385441796 cites W2898440040 @default.
• W4385441796 cites W2904153475 @default.
• W4385441796 cites W2905067644 @default.
• W4385441796 cites W2911837406 @default.
• W4385441796 cites W2919341774 @default.
• W4385441796 cites W2928210924 @default.
• W4385441796 cites W2962852416 @default.
• W4385441796 cites W2972836719 @default.
• W4385441796 cites W2988453505 @default.
• W4385441796 cites W3202269121 @default.
• W4385441796 cites W3203953137 @default.
• W4385441796 cites W4306353166 @default.
• W4385441796 cites W4378618906 @default.
• W4385441796 cites W3145571634 @default.
• W4385441796 doi "https://doi.org/10.1111/febs.16917" @default.
• W4385441796 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37525425" @default.
• W4385441796 hasPublicationYear "2023" @default.
• W4385441796 type Work @default.
• W4385441796 citedByCount "0" @default.
• W4385441796 crossrefType "journal-article" @default.
• W4385441796 hasAuthorship W4385441796A5012681781 @default.
• W4385441796 hasAuthorship W4385441796A5017525793 @default.
• W4385441796 hasAuthorship W4385441796A5023688006 @default.
• W4385441796 hasAuthorship W4385441796A5036672262 @default.
• W4385441796 hasBestOaLocation W43854417961 @default.
• W4385441796 hasConcept C104317684 @default.
• W4385441796 hasConcept C105702510 @default.
• W4385441796 hasConcept C131934819 @default.
• W4385441796 hasConcept C145059251 @default.
• W4385441796 hasConcept C166703698 @default.
• W4385441796 hasConcept C201853390 @default.
• W4385441796 hasConcept C207001950 @default.
• W4385441796 hasConcept C2779867133 @default.
• W4385441796 hasConcept C2779959927 @default.
• W4385441796 hasConcept C54355233 @default.
• W4385441796 hasConcept C67705224 @default.
• W4385441796 hasConcept C86803240 @default.
• W4385441796 hasConcept C95444343 @default.
• W4385441796 hasConceptScore W4385441796C104317684 @default.
• W4385441796 hasConceptScore W4385441796C105702510 @default.
• W4385441796 hasConceptScore W4385441796C131934819 @default.
• W4385441796 hasConceptScore W4385441796C145059251 @default.
• W4385441796 hasConceptScore W4385441796C166703698 @default.
• W4385441796 hasConceptScore W4385441796C201853390 @default.
• W4385441796 hasConceptScore W4385441796C207001950 @default.
• W4385441796 hasConceptScore W4385441796C2779867133 @default.
• W4385441796 hasConceptScore W4385441796C2779959927 @default.
• W4385441796 hasConceptScore W4385441796C54355233 @default.
• W4385441796 hasConceptScore W4385441796C67705224 @default.
• W4385441796 hasConceptScore W4385441796C86803240 @default.
• W4385441796 hasConceptScore W4385441796C95444343 @default.
• W4385441796 hasFunder F4320334764 @default.
• W4385441796 hasFunder F4320334789 @default.
• W4385441796 hasLocation W43854417961 @default.
• W4385441796 hasLocation W43854417962 @default.

• next