Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385442034> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W4385442034 abstract "In 2022 as in 1884, the clinical presentation of uncomplicated malaria is unspecific: fever of variable intensity, continuous or rhythmic, chills, flu syndrome, headache, respiratory and digestive disorders. At any time, it can evolve into a severe form (ex-pernicious attack or cerebral malaria) or even lethal. By reading again Alphonse Laveran's book on malarial fevers, we realized to what extent the observations made at that time allowed for a methodical and orderly description of the clinical forms of malaria, very close to what we can still observe today. No symptom or sign is pathognomonic of the disease. Only the detection of plasmodia or malaria microbes by direct or immuno-chromatographic methods allows for diagnostic confirmation, which is a prerequisite for the implementation of a curative treatment.Serendipity, synthetic chemistry and traditional medicine are the three methods that led to the discovery and large-scale production of antimalarial drugs. Serendipity for quinine, synthetic chemistry for chloroquine, and research conducted around traditional Chinese medicine for artemisinin and its derivatives. The latter have marked a real revolution in the management of malaria, both in its uncomplicated and severe forms. However, as with other antimalarial drugs, its medium- and long-term efficacy is compromised by the emergence and spread of resistance in malaria parasites, particularly P. falciparum. The control and eradication of malaria therefore require continued research in both prevention and therapy.The disease so well described by Alphonse Laveran has not yet said its last word…." @default.
- W4385442034 created "2023-08-02" @default.
- W4385442034 creator A5014747787 @default.
- W4385442034 creator A5080671537 @default.
- W4385442034 date "2023-06-30" @default.
- W4385442034 modified "2023-10-16" @default.
- W4385442034 title "[Malaria in 2022: clinical and therapeutic aspects]." @default.
- W4385442034 cites W1673362020 @default.
- W4385442034 cites W2094367634 @default.
- W4385442034 cites W2110383454 @default.
- W4385442034 cites W2259930542 @default.
- W4385442034 cites W3008406670 @default.
- W4385442034 cites W3112801398 @default.
- W4385442034 cites W3172784504 @default.
- W4385442034 cites W3209322500 @default.
- W4385442034 cites W4206189653 @default.
- W4385442034 cites W4225574613 @default.
- W4385442034 cites W4225825919 @default.
- W4385442034 doi "https://doi.org/10.48327/mtsi.v3i2.2023.378" @default.
- W4385442034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37525671" @default.
- W4385442034 hasPublicationYear "2023" @default.
- W4385442034 type Work @default.
- W4385442034 citedByCount "0" @default.
- W4385442034 crossrefType "journal-article" @default.
- W4385442034 hasAuthorship W4385442034A5014747787 @default.
- W4385442034 hasAuthorship W4385442034A5080671537 @default.
- W4385442034 hasConcept C111472728 @default.
- W4385442034 hasConcept C126322002 @default.
- W4385442034 hasConcept C138885662 @default.
- W4385442034 hasConcept C141071460 @default.
- W4385442034 hasConcept C177713679 @default.
- W4385442034 hasConcept C203014093 @default.
- W4385442034 hasConcept C2776120307 @default.
- W4385442034 hasConcept C2776407475 @default.
- W4385442034 hasConcept C2777425658 @default.
- W4385442034 hasConcept C2777617192 @default.
- W4385442034 hasConcept C2778048844 @default.
- W4385442034 hasConcept C2778371730 @default.
- W4385442034 hasConcept C2778594517 @default.
- W4385442034 hasConcept C2779119418 @default.
- W4385442034 hasConcept C2779134260 @default.
- W4385442034 hasConcept C71924100 @default.
- W4385442034 hasConceptScore W4385442034C111472728 @default.
- W4385442034 hasConceptScore W4385442034C126322002 @default.
- W4385442034 hasConceptScore W4385442034C138885662 @default.
- W4385442034 hasConceptScore W4385442034C141071460 @default.
- W4385442034 hasConceptScore W4385442034C177713679 @default.
- W4385442034 hasConceptScore W4385442034C203014093 @default.
- W4385442034 hasConceptScore W4385442034C2776120307 @default.
- W4385442034 hasConceptScore W4385442034C2776407475 @default.
- W4385442034 hasConceptScore W4385442034C2777425658 @default.
- W4385442034 hasConceptScore W4385442034C2777617192 @default.
- W4385442034 hasConceptScore W4385442034C2778048844 @default.
- W4385442034 hasConceptScore W4385442034C2778371730 @default.
- W4385442034 hasConceptScore W4385442034C2778594517 @default.
- W4385442034 hasConceptScore W4385442034C2779119418 @default.
- W4385442034 hasConceptScore W4385442034C2779134260 @default.
- W4385442034 hasConceptScore W4385442034C71924100 @default.
- W4385442034 hasIssue "2" @default.
- W4385442034 hasLocation W43854420341 @default.
- W4385442034 hasOpenAccess W4385442034 @default.
- W4385442034 hasPrimaryLocation W43854420341 @default.
- W4385442034 hasRelatedWork W1009432462 @default.
- W4385442034 hasRelatedWork W1482118833 @default.
- W4385442034 hasRelatedWork W1592864042 @default.
- W4385442034 hasRelatedWork W2291086493 @default.
- W4385442034 hasRelatedWork W229809859 @default.
- W4385442034 hasRelatedWork W2394565064 @default.
- W4385442034 hasRelatedWork W2410056375 @default.
- W4385442034 hasRelatedWork W2413609373 @default.
- W4385442034 hasRelatedWork W3199344978 @default.
- W4385442034 hasRelatedWork W3201345559 @default.
- W4385442034 hasVolume "3" @default.
- W4385442034 isParatext "false" @default.
- W4385442034 isRetracted "false" @default.
- W4385442034 workType "article" @default.