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• W4385442068 abstract "Cancer cells hijack metabolic pathways in order to provide themselves with building blocks to support their proliferation and survival. Upregulation and addiction to de novo serine/glycine synthesis is an example of metabolic rewiring in cancer cells whereby serine and glycine are synthesised via a side branch of glycolysis. In this review, we focus on upregulation of endogenous serine/glycine production in acute leukemia, namely T-cell acute leukemia (T-ALL) and acute myeloid leukemia (AML). Several genetic lesions directly driving the serine/glycine addiction in acute leukemia have been established. Additionally, indirect regulation of de novo serine/glycine synthesis is observed in acute leukemia." @default.
• W4385442068 created "2023-08-02" @default.
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• W4385442068 date "2023-08-01" @default.
• W4385442068 modified "2023-10-14" @default.
• W4385442068 title "Drivers of <i>de novo</i> Serine/Glycine synthesis in acute leukemia" @default.
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• W4385442068 doi "https://doi.org/10.1002/1873-3468.14700" @default.
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