Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385442955> ?p ?o ?g. }
- W4385442955 abstract "ABSTRACT Glucocorticoid resistance is commonly observed in depression, and has been linked to reduced expression and/or function of the glucocorticoid receptor (NR3C1 in human, hereafter referred to as GR). Previous studies have shown that GR-mutant zebrafish exhibit behavioural abnormalities that are indicative of an affective disorder, suggesting that GR plays a role in brain function. We compared the brain methylomes and brain transcriptomes of adult wild-type and GR-mutant zebrafish, and identified 249 differentially methylated regions (DMRs) that are regulated by GR. These include a cluster of CpG sites within the first intron of fkbp5, the gene encoding the glucocorticoid-inducible heat shock protein co-chaperone Fkbp5. RNA-sequencing analysis revealed that genes associated with chaperone-mediated protein folding, the regulation of circadian rhythm and the regulation of metabolism are particularly sensitive to loss of GR function. In addition, we identified subsets of genes exhibiting GR-regulated transcription that are known to regulate behaviour, and are linked to unipolar depression and anxiety. Taken together, our results identify key biological processes and novel molecular mechanisms through which the GR is likely to mediate responses to stress in the adult zebrafish brain, and they provide further support for the zebrafish GR mutant as a model for the study of affective disorders." @default.
- W4385442955 created "2023-08-02" @default.
- W4385442955 creator A5006439423 @default.
- W4385442955 creator A5016631589 @default.
- W4385442955 creator A5025229438 @default.
- W4385442955 creator A5029039823 @default.
- W4385442955 creator A5032244258 @default.
- W4385442955 creator A5035578057 @default.
- W4385442955 creator A5043240897 @default.
- W4385442955 creator A5060706701 @default.
- W4385442955 creator A5066046626 @default.
- W4385442955 creator A5087879215 @default.
- W4385442955 creator A5088845690 @default.
- W4385442955 creator A5092575982 @default.
- W4385442955 date "2023-09-01" @default.
- W4385442955 modified "2023-10-14" @default.
- W4385442955 title "Glucocorticoid Receptor regulates protein chaperone, circadian clock and affective disorder genes in the zebrafish brain" @default.
- W4385442955 cites W1505140921 @default.
- W4385442955 cites W1969353942 @default.
- W4385442955 cites W1972121275 @default.
- W4385442955 cites W1974495707 @default.
- W4385442955 cites W1985336737 @default.
- W4385442955 cites W1996083201 @default.
- W4385442955 cites W1999603779 @default.
- W4385442955 cites W2007636259 @default.
- W4385442955 cites W2016870566 @default.
- W4385442955 cites W2025230659 @default.
- W4385442955 cites W2025646443 @default.
- W4385442955 cites W2026530704 @default.
- W4385442955 cites W2027635336 @default.
- W4385442955 cites W2034836489 @default.
- W4385442955 cites W2035013882 @default.
- W4385442955 cites W2035618305 @default.
- W4385442955 cites W2036194871 @default.
- W4385442955 cites W2036845348 @default.
- W4385442955 cites W2036897871 @default.
- W4385442955 cites W2037599090 @default.
- W4385442955 cites W2039593919 @default.
- W4385442955 cites W2042811547 @default.
- W4385442955 cites W2045295821 @default.
- W4385442955 cites W2051465150 @default.
- W4385442955 cites W2053208961 @default.
- W4385442955 cites W2055747883 @default.
- W4385442955 cites W2057462189 @default.
- W4385442955 cites W2060446375 @default.
- W4385442955 cites W2065498897 @default.
- W4385442955 cites W2068294231 @default.
- W4385442955 cites W2070684401 @default.
- W4385442955 cites W2072970694 @default.
- W4385442955 cites W2078832578 @default.
- W4385442955 cites W2084620487 @default.
- W4385442955 cites W2094107463 @default.
- W4385442955 cites W2109458697 @default.
- W4385442955 cites W2116629441 @default.
- W4385442955 cites W2124159257 @default.
- W4385442955 cites W2124799197 @default.
- W4385442955 cites W2130410032 @default.
- W4385442955 cites W2131271579 @default.
- W4385442955 cites W2131374955 @default.
- W4385442955 cites W2135805255 @default.
- W4385442955 cites W2139122477 @default.
- W4385442955 cites W2144086069 @default.
- W4385442955 cites W2145506897 @default.
- W4385442955 cites W2148337554 @default.
- W4385442955 cites W2149901479 @default.
- W4385442955 cites W2154999279 @default.
- W4385442955 cites W2160091872 @default.
- W4385442955 cites W2161227972 @default.
- W4385442955 cites W2163215199 @default.
- W4385442955 cites W2166006462 @default.
- W4385442955 cites W2166574880 @default.
- W4385442955 cites W2169456326 @default.
- W4385442955 cites W2179438025 @default.
- W4385442955 cites W2260787119 @default.
- W4385442955 cites W2265026139 @default.
- W4385442955 cites W2306482506 @default.
- W4385442955 cites W2406124884 @default.
- W4385442955 cites W2407888728 @default.
- W4385442955 cites W2432815617 @default.
- W4385442955 cites W2484659268 @default.
- W4385442955 cites W2537679995 @default.
- W4385442955 cites W2563474852 @default.
- W4385442955 cites W2578984598 @default.
- W4385442955 cites W2606520198 @default.
- W4385442955 cites W2607813717 @default.
- W4385442955 cites W2649865612 @default.
- W4385442955 cites W2751708584 @default.
- W4385442955 cites W2805903905 @default.
- W4385442955 cites W2810143528 @default.
- W4385442955 cites W2906506916 @default.
- W4385442955 cites W2909106263 @default.
- W4385442955 cites W2922148374 @default.
- W4385442955 cites W2930925102 @default.
- W4385442955 cites W2942157380 @default.
- W4385442955 cites W2948824557 @default.
- W4385442955 cites W2953903869 @default.
- W4385442955 cites W2964018626 @default.
- W4385442955 cites W2970514148 @default.
- W4385442955 cites W2977214917 @default.
- W4385442955 cites W2982509876 @default.